Abstract Alzheimer's disease (AD) is a diverse with complex pathophysiology. The presence of extracellular β-amyloid deposition as neuritic plaques and intracellular accumulation hyper-phosphorylated tau neurofibrillary tangles remain the core neuropathologic criteria for diagnosing disease. Nonetheless, several recent basic discoveries have revealed significant pathogenic roles other essential cellular molecular processes. Previously, there were not so many disease-modifying medications...

Cucumis sativus L., widely cultivated as an edible vegetable. Its seeds are well reputed for cardiovascular preventive properties. However, the mechanisms underlying protection of C. still unidentified. Therefore, this study utilized a metabolomics approach to investigate putative in myocardial infarction (MI) and vitro models vasoconstriction, atrium, invasive blood pressure measurement. Results showed that Cu.EtOH extract vasorelaxant response with potent hypotensive effect normotensive...

Pyrus pashia Buch.-Ham. ex D. Don. has been used conventionally by many communities in the Himalayan region for management of gastrointestinal, respiratory, and vascular complications. Set against this background, study was carried out to justify scientific basis validate folkloric uses fruits (Pp.Cr) traditional systems medicine.The crude ethanol extract tested vitro on isolated rabbit jejunum, tracheal, aorta preparations. The responses tissues were recorded using isotonic transducers...

Ethnopharmacological relevance Pelargonium zonale (L.) L'Hér. ex Aiton ( P.zonale) is used against various cardiovascular, gastrointestinal and respiratory diseases involving smooth muscles relaxation. It traditionally for the treatment of diarrhea, gastropathy, toothache. Aim study The current was designed to validate its conventional applications, we conducted investigational studies evaluate potential mode operation in management disorders pertaining cardiovascular system, tract, tract...

Isodon rugosus is used in folk Pakistan traditional practices to cure ailments related gastrointestinal, respiratory and cardiovascular problems. Present study was undertaken validate these folkloric uses.A crude methanol extract of the aerial parts (Ir.Cr.) for both vitro vivo experiments. The plant tested on isolated rabbit jejunum preparations possible presence spasmolytic activity. Moreover, tracheal aorta were ascertain relaxant effects extract. Acetylcholinesterase...

In addition to the nutritional benefits of Cucumis melo L., herbalists in Pakistan and India employ seeds treat various ailments. This study aimed determine regulatory role C. calcium-mediated smooth muscle contraction.We identified quantified phytochemicals with LC ESI-MS/MS HPLC, then conducted vitro vivo tests confirm involvement relaxation. Then, diarrhea-predominant irritable bowel syndrome gene datasets from NCBI GEO were acquired, DEGs WGCNA followed by functional enrichment analysis....

Lactuca serriola L. has traditionally been used in folkloric medicine to manage respiratory, gastrointestinal, and multiple other ailments. The present study was undertaken explore the effect of methanol extract on isolated rabbit tissue preparations, that is, jejunum, trachea, aorta an attempt validate its use traditional for vascular application jejunum preparations exhibited concentration-dependent spasmogenic (0.03 3.0 mg/mL), but interestingly further increase concentration (5.0 mg/mL)...

Cardiovascular diseases (CVDs) are a significant cause of morbidity and death in the current world, posing challenge to both developing industrialized nation's health systems. Citrullus lanatus (Thunb.) Matsum. & Nakai. seeds have long been utilized supplement enhance treat cardiovascular illnesses. However, its treatments for CVDs still unknown. More research is required fully comprehend impact C. on vasorelaxation myocardial infractions.Therefore, an integrated metabolomics profiling...

Murraya paniculata is traditionally used for management of gut, air way and cardiovascular disorders. The study was conducted provision pharmacological rationalization folkloric uses in problems. Aqueous-ethanolic extract Mp.Cr tested using vitro techniques on isolated tissue rabbit (jejunum, trachea aorta) to detect the possible presence spasmolytic activity. responses tissues were recorded isotonic transducers coupled with PowerLab data acquisition system. Application relaxed spontaneous...

L. is globally cultivated as an edible vegetable. Besides its nutritional benefits, it used in traditional medicines against various ailments. The current study was designed to elucidate the multi-target mechanisms of a

Solena heterophylla Lour. has traditionally been used in the management of diseases pertaining to gastrointestinal, respiratory and vascular system present study was undertaken validate its traditional uses. The aqueous ethanolic extract Lour (Sh.Cr) tested in-vitro on isolated rabbit jejunum, tracheal aorta preparations. responses tissues were recorded using isotonic transducers coupled with PowerLab data acquisition system. (0.03-1.0 mg/ml) application spontaneous contractions jejunum...

Background: Tamarix dioica is traditionally used to manage various disorders related smooth muscle in the gastrointestinal, respiratory, and cardiovascular systems. This study was planned establish a pharmacological basis for uses of certain medical conditions digestive, systems, explore underlying mechanisms. Methods: A phytochemical performed by preliminary methods, followed HPLC-DAD spectrometric methods. In vivo evaluation crude hydromethanolic extract T. (TdCr) done with...

Apart from the nutritional value, Cucumis sativus L. has also been used in traditional medicine of Iran, Pakistan, and India. Its seeds are by herbalists to treat gastrointestinal, respiratory, urinary problems. However, more investigations required explain its mechanisms for treating GI, diseases. Accordingly, aim present work was investigate antispasmodic, bronchodilator, antidiarrheal activities C. extracts underlying action. For this purpose, sequential were prepared n-hexane,...

Objective: To discover the mechanism behind ameliorative effects of Michelia champaca (M. champaca) in gastrointestinal, respiratory and cardiovascular disorders. Methods: Anti- spasmodic potential was evaluated by trying M. extract (aqueous:ethanolic) on rabbit aorta, trachea jejunum vitro. Isotonic isometric transducers coupled with Power Lab data acquisition system used to record responses isolated tissues. Results: relaxed spontaneous high K+ (80 mmol/L)-induced contractions preparation...

Populus ciliata Wall ex. Royle has folkloric repute to treat various cardiovascular ailments and related disorders. The current study was designed evaluate the toxic profile, cardioprotective hypotensive effects of (Wall. ex Royle). crude ethanolic extract (Pc. Cr) its aqueous Aq) & organic Dcm) fractions were tested on isolated aorta rat rabbit having intact non-intact endothelium respectively. Pc. Cr Aq relaxed contractions induced by PE (1 µM)-induced K+ (80 mM)-induced aorta, possibly...