A5078179759- Cancer Genomics and Diagnostics
- Cancer-related Molecular Pathways
- Ocular Oncology and Treatments
- Ferroptosis and cancer prognosis
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- RNA Research and Splicing
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Radiomics and Machine Learning in Medical Imaging
- Bladder and Urothelial Cancer Treatments
- Occupational and environmental lung diseases
- Ubiquitin and proteasome pathways
- DNA Repair Mechanisms
- Medical Imaging Techniques and Applications
- Cancer-related molecular mechanisms research
- Genomics and Chromatin Dynamics
- Cancer Treatment and Pharmacology
- Trauma Management and Diagnosis
- Single-cell and spatial transcriptomics
- PARP inhibition in cancer therapy
- Renal cell carcinoma treatment
- Genomics and Rare Diseases
The Ohio State University
2013-2024
University of Colorado Denver
2023
University of New Mexico
2022
Dartmouth College
2021-2022
Oregon Health & Science University
2021
Neurological Surgery
2021
Bangabandhu Sheikh Mujib Medical University
2017-2020
Walter Reed National Military Medical Center
2018
The University of Texas MD Anderson Cancer Center
2018
University of Nebraska Medical Center
2014
The clinical phenotype of BAP1 hereditary cancer predisposition syndrome (MIM 614327) includes uveal melanoma (UM), cutaneous (CM), renal cell carcinoma (RCC), and mesothelioma. However, the frequency in patients with UM association other cancers are still not clear. In this study, we screened 46 previously untested, unrelated high risk for germline mutation . We also studied four additional a personal or family history suggestive syndrome. identified three pathogenic mutations (c.2050...
Uveal melanoma (UM) is the most commonly diagnosed primary intraocular tumor in adults. Familial UM (FUM), defined as two or more family members with UM, rare and estimated at less than 1% of all UM. Currently, BAP1 only gene known to contribute significant risk for In this study we aimed estimate frequency mutation FUM characterize personal histories other cancers these families. We identified 32 families FUM, including seven previously reported by our group. testing was carried out direct...
Background: To evaluate the prevalence of BAP1 germline mutations in a series young patients with uveal melanoma (UM), diagnosed before age 30.Materials and Methods: The study was carried out on 14 (average 21.4 years, range 3 months to 29 years). Germline DNA extracted from peripheral blood. sequencing using direct all exons adjacent intronic sequences. We also tested for additional melanoma-associated candidate genes CDKN2A CDK4 (exon 4).Results: identified one patient pathogenic mutation...
Abstract While the role of genetic risk factors in etiology uveal melanoma (UM) has been strongly suggested, susceptibility to UM is currently vastly unexplored. Due shared epidemiological between cutaneous (CM) and UM, this study we have selected 28 SNPs identified as variants previous genome-wide association studies on CM or CM-related host phenotypes (such pigmentation eye color) tested them for with risk. By logistic regression analysis 272 cases 1782 controls using an additive model,...
To support the introduction of COVID-19 vaccine, World Health Organization and its partners developed an interactive virtual learning initiative through which vaccination stakeholders could receive latest guidance, ask questions, share their experiences. This initiative, implemented between 9 February 2021 15 June 2021, included engagement technical experts participants during a 15-session webinar series as well web text-messaging discussions in English French.This article uses mixed-methods...
Vasovagal reaction (VVR) is a very common adverse event related to blood donation. No study has been conducted in Pakistan estimate the prevalence of VVR donors. This was immediate donors Karachi, Pakistan. The two banks Karachi. Data regarding development were documented. effect donation on vital parameters like pulse rate, pressure (BP), temperature and respiratory rate also observed. Six hundred seventy-four recruited. All who consented males. Weakness dizziness most symptoms which...
Abstract Diuresis for hospitalized patients with acute decompensated heart failure is a routine clinical practice but one that remains reliant on error‐prone and resource‐intensive intake output weight measurements subject to wide provider variation. We sought use quality improvement approaches implement data‐driven predictive diuresis protocol based natriuresis using the electronic health record titrate dosing. Our initiative did not result in significant reductions length of stay...
Background and Aims: Cardioplegia is used to arrest the heart after application of an aortic cross-clamp that interrupts coronary circulation. Commonly St. Thomas’II cardioplegic solution has be repeated at short intervals, which may cause additional myocardial injury. So, this study done determine whether del Nido (DN) cardioplegia, a longer duration with single dose, provides equivalent or better protection as compared Thomas’ II Cardioplegia.
 Methods: A prospective observational was...
Increased mortality in patients admitted to hospitals on weekends is a well-described phenomenon labeled the "weekend effect." Studies evaluating weekend effect intensive care units (ICUs) have arrived at conflicting results. Identifying for critically-ill may inform clinical pathways and resource allocation.Determine association of initiation mechanical ventilation (MV) upon admission versus weekday with hospital mortality.We conducted retrospective cohort study non-surgical adult using...
1543 Background: Uveal melanoma (UM) is the most common primary intraocular tumor in adult, but its etiology for part remains unclear. It has been suggested that genetic susceptibility plays an important role UM, currently known germline mutations BAP1 or CDKN2A, explain < 3% of UM familial risk. In general population risk factors are vastly unexplored. Because previously reported association and cutaneous (CM), we hypothesized there a shared to both phenotypes. Unlike which systematic GWAS...
A 12 year old boy with Marfan syndrome associated severe mitral regurgitation underwent successful valve replacement. Careful evaluation of the cardiovascular system and specific surgical intervention help long-term survival patients.
Stedelin, Brittany; Pangelinan, Kelsey; Edwards, Jared; Cheaney, Barry II BS; Rai, Karan; Raslan, Ahmed M.T; Ernst, Lia Author Information
Journal of Minimally Invasive Spine Surgery & Technique (JMISST) is the official journal Korean Society (KOMISS) for publication research results about minimally invasive spinal surgery (MISS), including studies in endoscopic surgery, procedure degenerative spine disease, pain intervention, and fusion or trauma, neuroscience, neurology, molecular biology biomechanics etc. Articles with helpful information MISS such as reports rare cases technical review special devices equipment are also available