A5055196559- Autoimmune and Inflammatory Disorders
- Cutaneous lymphoproliferative disorders research
- Parvovirus B19 Infection Studies
- Heat shock proteins research
- Skin Diseases and Diabetes
- Healthcare and Venom Research
- Cancer-related molecular mechanisms research
- Lymphoma Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Cutaneous Melanoma Detection and Management
- Dermatology and Skin Diseases
- Hepatitis B Virus Studies
- Autophagy in Disease and Therapy
- Viral-associated cancers and disorders
- Histiocytic Disorders and Treatments
- Immunodeficiency and Autoimmune Disorders
- Ocular Oncology and Treatments
- Hypertrophic osteoarthropathy and related conditions
- Bacillus and Francisella bacterial research
- Sarcoidosis and Beryllium Toxicity Research
- Inflammatory Myopathies and Dermatomyositis
- Genetic and rare skin diseases.
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Immunotherapy and Immune Responses
- Hippo pathway signaling and YAP/TAZ
Chongqing Medical University
2018-2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023
Children's Hospital of Chongqing Medical University
2018-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2013
Wenzhou Medical University
2010
Chronic autoimmune urticaria (CAU) is a common skin disease and remains unclear understanding of pathogenesis in the vast majority cases. In order to explore new therapy for CAU, current study was performed investigate possible functioning Oncostatin M receptor (OSMR) gene autoimmunity CAU via regulation JAK/STAT3 signaling pathway. tissues from 24 patients normal subjects were collected. Hematoxylin-eosin (HE) staining conducted count eosinophils, immunohistochemistry carried out detect...
Abstract Several strategies have been used to enhance the vaccine-induced immunity of peptide vaccines and effective therapeutic benefits, including utilization heat shock proteins (HSP), especially HSP70 family. HSP110 exhibits a higher binding affinity with protein is capable enhancing immunogenicity antigens; however, whether can also increase efficiency vaccine remains unclear. Here, we investigated mHSP110 as chaperone immunoadjuvant immune response HPV16 oncoprotein E7-derived CTL...
Our previous research verified that HSP (heat shock protein) 110 could enhance the anti-tumor effect of HPV16 E749-57 epitope. In this study, to optimize immunotherapy vaccine type, we developed and evaluated immunity a nanoparticle format assembling with E749-57-HSP110 fusion expression plasmid RGD-GGG-K18 polypeptide. The was self-assembled from positively charged polypeptide negatively pIRES2-3× E7-HSP110-EGFP. particle size, stability, protein target ability were determined,...
This case report describes a 19-month-old boy pearly papules in the perianal area and on thighs, clawhand, contracture of large joints, gingival hyperplasia who was diagnosed with infantile systemic hyalinosis.
A 3-year-old girl presented with recurrent multiple painful ulcerative lesions for 10 months. The ulcer on the forehead rapidly progressed and involved both cheeks nose yellowish purulent discharge in recent 20 days (figure 1A). She was treated antibiotics resulting no response. had systemic, gastrointestinal arthritic symptoms. Laboratory examination found elevated white blood cell (39.72×109/L) decreased haemoglobin (77 g/L). Bone marrow …
Phacomatosis pigmentokeratotica (PPK) is characterized by the coexistence of speckled lentiginous nevus and sebaceous.• Raynaud phenomenon may be an unreported association with PPK.FIGURE 1. Nevus sebaceous coexisted nevus.
Objective To investigate the safety and clinical value of drug patch tests in diagnosing delayed hypersensitivity reactions (DDHR)in children. Methods Fifty-four pediatric patients with DDHR(experimental group)underwent suspected culprit drugs, 10 mild DDHR proceeded to undergo provocation for evaluation diagnostic accuracy tests. Twenty healthy children(control common drugs specificity tests. Results Drug were positive 16 out 54 experimental group a rate 29.63%, but none 20...
Objective To investigate whether sirolimus increases the autophagy level in HaCaT human keratinocytes induced by ultraviolet B (UVB) irradiation.Methods cells were irradiated UVB of O,25 and 50 mJ/cm2 respectively.After additional 6-hour culture,monodansylcadaverin (MDC) staining was canied out to detect autophagosomes cells.Then,some classified into 4 groups be with (25 respectively) alone or followed (10 nmol/L) treatment,those remaining untreated served as blank control group,and those...
Objective To observe the changes in proliferative activity of and autophagosome formation human HaCaT keratinocytes primary after different doses ultraviolet B (UVB) radiation,and to assess potential relationship between proliferation impairment formation.Methods Both cultured cells from foreskin were irradiated with (5,10,20and 40 mJ/cm2) UVB.Those receiving no irradiation served as control.After additional 12-hour culture,methyl thiazolyl tetrazolium (MTT) assay was performed evaluate...
[Objective] To observe the effects of autophagy induced by different doses ultraviolet B (UVB) irradiation on apeptosis in human skin fibroblasts.[Methods] Skin fibroblasts were isolated from circumcision specimen a 23-year-old healthy male,and subjected to primary culture.After 3 10 passages,the cells collected and applied following experiment.Methyl thiazolyl tetrazolium (MTT) assay was performed evaluate proliferation some treated with concentrations (0,0.5,2.0,5.0and 10.0 mmol/L)...
Autophagy is a lysosome-based degradation process of intracellular macromolecules or organelles.Recent research has suggested that autophagy exists in keratinocytes and involved keratinocyte differentiation.Senesceut die by autophagic programmed cell death.It been demonstrated induced some epithelial tumors,which may be associated with their invasiveness metastasis.Autophagy can alleviate the inflammation keratinocytes.Moreover,autophagy responsible for pharmacologic actions drugs,such as...