A5082515693- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Reproductive Physiology in Livestock
- Animal Behavior and Welfare Studies
- Milk Quality and Mastitis in Dairy Cows
- Cancer-related molecular mechanisms research
- Genetic Associations and Epidemiology
- Effects of Environmental Stressors on Livestock
- Genetics and Plant Breeding
University of Hohenheim
2022-2024
Genomic analyses commonly explore the additive genetic variance of traits. The non-additive variance, however, is usually small but often significant in dairy cattle. This study aimed at dissecting eight health traits that recently entered total merit index Germany and somatic cell score (SCS), as well four milk production by analysing dominance components. heritabilities were low for all (between 0.033 mastitis 0.099 SCS), moderate 0.261 energy yield 0.351 yield). For traits, contribution...
Claw diseases and mastitis represent the most important disease traits in dairy cattle with increasing incidences a frequently mentioned connection to milk yield. Yet, many studies aimed detect genetic background of both trait complexes via fine-mapping quantitative loci. However, little is known about genomic regions that simultaneously affect production traits. For this purpose, several tools local correlations have been developed. In study, we attempted detailed analysis as well their...
Abstract Background Claw diseases and mastitis represent the most important health issues in dairy cattle with a frequently mentioned connection to milk production. Although many studies have aimed at investigating this more detail by estimating genetic correlations, they do not provide information about causality. An alternative is carry out Mendelian randomization (MR) using variants investigate effect of an exposure on outcome trait mediated variants. No study has yet investigated causal...
Over the last decades, it was subject of many studies to investigate genomic connection milk production and health traits in dairy cattle. Thereby, incorporating functional information analyses has been shown improve understanding biological molecular mechanisms shaping complex accuracies prediction, especially small populations across-breed settings. Still, little is known about contribution different evolutionary genome partitioning subsets health. Thus, we performed a uni- bivariate...
Global genetic correlations as common estimates of pleiotropy across the genome fail to dissect absolute level shared genomic regions and their effects on various traits. Methods in human genetics that try transfer global local scale showed up recently but have not been applied livestock yet. One them is LOGODetect, scanning summary statistics for between two We LOGODetect a sample German Holstein cattle identify these milk production, mastitis claw disease traits found certain number...