Lymphocyte activation induces or increases the expression of several surface structures, some which are directly involved in cell growth such as receptors for IL-2 transferrin. In order to identify new structures characteristic activated lymphocytes, we developed a series mAb against functionally defined human T clones. present study report isolation termed BB18 recognizing, at surface, novel 150-kDa glycoprotein dimer whose on lymphocytes readily after their with various stimuli including...

The pathways used in the transport of retroviral genomes to nucleus are poorly identified. Analyzing intracellular localization incoming foamy viruses, we have found that Gag antigens and viral genome accumulate a distinct perinuclear domain identified as centrosome. Colchicine treatment completely abolished pericentriolar targeting human virus (HFV) proteins, suggesting role for microtubules proteins centrioles. Finally, demonstrate that, similarly immunodeficiency DNA, HFV DNA can enter...

One hundred fifty-five healthy nonagenarians, 45 men and 100 women, all French Caucasians, were phenotyped for alleles of the A, B, C, DR loci HLA complex. The observed antigen frequencies compared to those a control series 133 males 179 females whose ages ranged from 10 50 years. When comparing total young elderly series, no significant differences with respect distribution or heterozygosity at any loci. taking sex difference into account, however, an excess Cw1 was found in group (p less...

Improving protein efficiency in pork production is a desired goal regarding resource conservation and climate protection, whereby animal breeding has great potential for sustainable improvements. Nitrogen utilization (NUE) an important trait but laborious to measure. As blood urea nitrogen (BUN) can be used predict NUE, it often as indicator trait. Both NUE BUN were found heritable, however, microbial studies have not yet been carried out. The present study aimed investigate the role of...

Some infants infected with human immunodeficiency virus type 1 (HIV-1) rapidly develop a fatal disease characterized by severe lymphopenia. To explain the immune dysfunction, we proposed mechanism which nongeneration of CD4+ T cells is caused HIV-1 infection thymic cells. examine this hypothesis, primary triple-negative (TN; phenotypically CD3- CD4- CD8-), CD1a- TN, or CD1a+ TN cell subsets. Our data indicate that flow cytometry, and remain CD4 negative throughout culture period. We...

HLA antigens and clinical features in a series of 46 Caucasian patients (40 females, 6 males) definite repeatedly seronegative rheumatoid arthritis (RA) more than two years9 duration (mean 11.6 years) were compared with those 77 seropositive RA 110 controls the same ethnic geographic origin. Seronegative appeared to be less often erosive RA, had fewer extra-articular features. The frequency antigen DR1 was raised as (p = 0.006, relative risk 3) 0.05). HLA-DR4 slightly increased 0.05) but...

Abstract Improving the nutrient efficiency in pork production is required to reduce resource competition between human food and animal feed regarding diet components edible for humans minimize emissions relevant climate or environment. Thereby, protein utilization its equivalent nitrogen (NUE) play a major role. Breeding more (N) efficient pigs bears promising strategy improve such traits, however, directly phenotyping NUE based on N balance data neither cost‐efficient nor straightforward...

Association between HLA and multiple sclerosis (MS) was investigated at the population level on 100 MS patients genotyped for HLA‐A, B, C, DR Bf, Glo, 155 phenotyped same antigens. DR2 clearly confirmed, although its strength is rather weak. No other genetic marker could be related to disease, no haplotype nor any allelic combination recognized as specific, antigen genotype frequencies among diseased not ascertain mode of inheritance, dominance very likely. Computer analysis HLA, Glo age...

Background: Feather pecking is a well-known problem in layer flocks that causes animal welfare restrictions and contributes to economic losses. Birds’ gut microbiota has been linked feather pecking. This study aims characterize the microbial communities of two laying hen lines divergently selected for high (HFP) low (LFP) investigates if associated with or agonistic behavior. Methods: Besides phenotyping behavioral traits, from digesta mucosa ileum caeca were investigated using target...

Feather pecking (FP) is a longstanding serious problem in commercial flocks of laying hens. It highly polygenic trait and the genetic background still not completely understood. In order to find genomic regions influencing FP, selection signatures between hen lines divergently selected for high low feather were mapped using intra-population iHS inter-population FST approach. addition, existence an extreme subgroup FP hens (EFP) across both has been demonstrated by fitting mixture negative...

Summary A large F2 cross with 920 Japanese quail was used to map QTL for phosphorus utilization, calcium feed per gain and body weight gain. In addition, four bone ash traits were included, because it is known that they are genetically correlated the focal trait of utilization. Trait recording done at juvenile stage birds. The individuals genotyped genome‐wide about 4k SNPs a linkage constructed, which agreed well reference genome. mapping performed using multimarker regression analysis in...

The production environments of the German–Austrian Brown Swiss population show a wide range due to differences in topography, landscapes, local climates, and different farm management systems. Extensive systems such as organic farming have become increasingly popular recent decades because interest sustainability consumer preferences. Compared with conventional farmers, farmers put more weight on fitness traits. Besides official total merit index (TMI), selection applying relative economic...

Human thymic cell differentiation is almost totally unknown. In the present study we developed an in vitro system using human cloned cells to analyze precursor-progeny relationship. We obtained several CD4+CD8+ double positive clones that could give rise after weeks culture only either CD4 or CD8 single clones. By contrast isolated a unique pluripotent clone, termed B12, which differentiated into four phenotypically distinct T clones, namely double-positive CD4+CD8+, double-negative CD4-CD8-...

In this study, genome-wide association study (GWAS) results of porcine F2 crosses were used to map QTL in outcross Piétrain populations. For purpose, two (Piétrain × Meishan, n = 304; Wild Boar, 291) genotyped with the PorcineSNP60v2 BeadChip and phenotyped for dressing yield, carcass length, daily gain drip loss traits. GWASs conducted pooled cross applying single marker mixed linear models. investigated traits, between five (in total 15) core regions, spanning 250 segregating SNPs around a...

In the present study, data from four F2 crosses were analysed and used to study linkage disequilibrium (LD) structure within across crosses. Genome-wide association analyses (GWASes) for conductivity dressing out meat traits conducted using single-marker Bayesian multi-marker models pooled all Porcine generated distantly related founder breeds Wild Boar, Piétrain Meishan, as well a porcine cross closely breed an F1 Large White × Landrace pooled. A total of 2572 animals genotyped 62K SNP...

During the last two decades, many QTL (quantitative trait locus) mapping experiments in pigs have been conducted using F2 crosses established from outbred founder breeds. The breeds were frequently chosen Asian and European type A combination of next-generation sequencing, SNP (single nucleotide polymorphism) genotyping technology SNP-chips, genotype imputation techniques, can be used to infer sequence information all individuals a cost-effective way. aim present simulation study was analyze...

In 94 children suffering from cystic fibrosis, no abnormal frequencies of HLA markers the A and B locus were observed in comparison with distribution these antigens control series. Furthermore, genotypes seven pairs diseased sibs are incompatible hypothesis a closed linkage between CF--an autosomal recessive transmitted disease--and HLA.