A5103042890- Coordination Chemistry and Organometallics
- Catalytic Cross-Coupling Reactions
- Asymmetric Synthesis and Catalysis
- Catalytic C–H Functionalization Methods
- Chemical synthesis and alkaloids
- RNA and protein synthesis mechanisms
- Influenza Virus Research Studies
- Viral Infections and Vectors
- Advanced Synthetic Organic Chemistry
- Cyclopropane Reaction Mechanisms
- Respiratory viral infections research
- Fire effects on ecosystems
- Synthesis of heterocyclic compounds
- Viral Infections and Outbreaks Research
- Synthetic Organic Chemistry Methods
- Organoboron and organosilicon chemistry
- RNA Interference and Gene Delivery
- Bacteriophages and microbial interactions
- Catalytic Alkyne Reactions
- interferon and immune responses
- Peptidase Inhibition and Analysis
- Chemical Synthesis and Analysis
- Herpesvirus Infections and Treatments
- Viral Infections and Immunology Research
- DNA and Nucleic Acid Chemistry
Humboldt-Universität zu Berlin
2012-2024
Leibniz Institute of Environmental Medicine
2023-2024
Ludwig-Maximilians-Universität München
2006-2014
Universidad de Málaga
2008
Abstract The presence of LiCl considerably facilitates the insertion magnesium into various aromatic and heterocyclic bromides. Several functional groups, such as ‐OBoc, ‐OTs, ‐Cl, ‐F, ‐CF 3 , ‐OMe, ‐NMe 2 ‐N NR are well tolerated. a cyano group leads in some cases to competitive reduction organic halide corresponding ArH compound. sensitive groups methyl or ethyl ester is tolerated upon situ trapping intermediate reagent with ZnCl . This method can also be applied preparation functionalized...
In the presence of zinc dust (1.5-2.0 equiv) and LiCl equiv), various benzylic chlorides bearing functional groups (iodide, cyanide, ester, ketone) are smoothly converted at 25 degrees C to corresponding reagents without homo-coupling (<5%). The utility these is demonstrated by a short synthesis papaverine.
Organocopper compounds prepared by the transmetalation of functionalized arylmagnesium halides with CuCN·2LiCl undergo smooth cross-coupling reactions aryl fluorides and tosylates bearing a carbonyl function in ortho position presence Co(acac)2 (7.5 mol %), Bu4NI (1 equiv), 4-fluorostyrene (20 %) as promoters DME/THF/DMPU leading to polyfunctional aromatics or heterocycles.
A wide range of polyfunctional aryl, heteroaryl, alkyl, and benzylic zinc reagents were coupled with unsaturated halides bearing an acidic NH or OH function, using Pd(OAc)(2) (1 mol %) S-Phos (2 as catalyst without the need protecting groups.
A wide range of polyfunctional aryl, heteroaryl, alkyl, and benzylic zinc reagents were coupled with unsaturated aryl halides bearing an acidic NH or OH proton, using Pd(OAc)2 (1 mol %) S-Phos (2 as catalyst without the need protecting groups. similar nickel-catalyzed reaction is described. The relative kinetic basicity organozinc compounds well their stability toward protons also
Organic iodides bearing a cationic quaternary ammonium group at remote position react with zerovalent Pd complexes, Zn, or In leading to C−I bond insertion. The resulting charge-tagged organometallics can be detected by electrospray-ionization mass spectrometry, which provides detailed information on their stoichiometry, oxidation state, and coordination sphere. properties of the observed organopalladium -zinc intermediates largely agree previous findings, whereas organoindium species show...
Benzylic zinc reagents prepared by direct insertion of to benzylic chlorides in the presence LiCl undergo smooth cross-coupling reactions with aromatic chlorides, bromides and tosylates using Ni(acac)2 PPh3 as a catalyst system.
In this review we summarize the most important procedures for preparation of functionalized organzinc and organomagnesium reagents. addition, new methods polyfunctional aryl- heteroaryl zinc- magnesium compounds, as well Pd-catalyzed cross-coupling reactions, are reported herein. Experimental details given reactions in Supporting Information File 1 article.
Abstract The genome of influenza A viruses (IAV) is encoded in eight distinct viral ribonucleoproteins (vRNPs) that consist negative sense RNA (vRNA) covered by the IAV nucleoprotein. Previous studies strongly support a selective packaging model which vRNP segments are bundling to an octameric complex, integrated into budding virions. However, pathway(s) generating complete bundle not known. We here use multiplexed FISH assay monitor all vRNAs parallel human lung epithelial cells. Analysis...
Organozinc halides, which are prepared either by direct zinc insertion or halogen−magnesium exchange and subsequent transmetalation with ZnCl2, react smoothly commercially available trichloroacetyl isocyanate to give, after hydrolysis, the corresponding primary amides. This method is compatible a variety of functional groups such as an ester cyano group. Also heterocyclic-, alkenyl, acetylenic reagents converted amides under these conditions.
Highly functionalized cyclic and acyclic alkenylzinc reagents bearing functional groups such as aldehyde, keto, ester were readily prepared by either direct zinc insertion in the presence of LiCl or magnesium ZnCl2. Subsequent functionalization reactions, Negishi cross-couplings, acylations, allylations, furnished polyfunctional compounds excellent yields. As a service to our authors readers, this journal provides supporting information supplied authors. Such materials are peer reviewed may...
Lateral partitioning of lipid-modified molecules between liquid-disordered (ld) and liquid-ordered (lo) domains depends on the type lipid modification, presence a spacer, membrane composition, temperature. Here, we show that lo domain palmitoylated peptide nucleic acid (PNA) can be influenced by formation four-component complex with ld tocopherol-modified DNA: PNA-DNA partitioned into domains. Enzymatic cleavage DNA linker led to disruption restored initial distribution lipophilic acids...
A new method for the preparation of highly functionalized benzylic zinc chlorides by direct insertion dust into corresponding in presence LiCl is described without formation homocoupling products (<5 %). Various reactions these reagents with a broad range electrophiles, which lead to polyfunctionalized products, are reported. In particular, cross-coupling aromatic chlorides, bromides, and tosylates [Ni(acac)(2)] (acac=acetylacetonate) PPh(3) proceeded good excellent yields give diaryl...
Abstract Readily available 1,1‐dichloro‐2‐alkynes are versatile starting materials for the synthesis of polyfunctionalized allenes. They can be prepared from commercially terminal alkynes in a two‐step procedure. The Cu‐mediated reaction several 1,1‐propargylic derivatives with functionalized alkyl, benzylic, or allylic zinc reagents proceeds exclusively S N 2′ selectivity and allows rapid efficient chloroallenes. These chloroallenes undergo novel Cu I ‐catalyzed substitution arylmagnesium...
The family Hantaviridae comprises a diverse group of virus species and is considered an emerging global public health threat. Individual hantavirus differ considerably in terms their pathogenicity but also cell biology host-pathogen interactions. In this study, we focused on the most prevalent pathogenic Europe, Puumala (PUUV), investigated entry internalization PUUV into mammalian cells. We show that both clathrin-mediated endocytosis macropinocytosis are cellular pathways exploited by to...
ABSTRACT Infected peripheral blood mononuclear cells (PBMC) effectively transport equine herpesvirus type 1 (EHV-1), but not EHV-4, to endothelial (EC) lining the vessels of pregnant uterus or central nervous system, a process that can result in abortion myeloencephalopathy. We examined, using dynamic vitro model, differences between EHV-1 and EHV-4 infection PBMC PBMC-EC interactions. In order evaluate viral transfer infected EC, cocultivation assays were performed. Only was transferred...
Abstract Hantavirus assembly and budding are governed by the surface glycoproteins Gn Gc. In this study, we investigated of Puumala, most abundant species in Europe, using fluorescently labeled wild-type constructs cytoplasmic tail (CT) mutants. We analyzed their intracellular distribution, co-localization oligomerization, applying comprehensive live, single-cell fluorescence techniques, including confocal microscopy, imaging flow cytometry, anisotropy Number&Brightness analysis....
Hoch funktionalisierte cyclische und acyclische Alkenylzinkreagentien mit Aldehyd-, Keto- oder Estergruppen können einfach durch direkte Zn-Insertion in Gegenwart von LiCl Mg-Insertion ZnCl2 hergestellt werden. Mehrfach Produkte wurden nachfolgende Funktionalisierungsreaktionen wie Negishi-Kreuzkupplungen, Acylierungen Allylierungen exzellenten Ausbeuten erhalten. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are...
The influenza A virus (IAV) genome is segmented into eight viral ribonucleoproteins, each expressing a negatively oriented RNA (vRNA). Along the infection cycle, highly abundant single-stranded small RNAs (svRNA) are transcribed in segment-specific manner. sequences of svRNAs and vRNA 5'-ends identical conserved among all IAV strains. Here, we demonstrate that these can be used as target for pan-selective sensor infection. To this end, complementary fluorescent forced-intercalation (IAV...
Corrected by: Cobalt-Catalyzed Cross-Coupling Reactions of Heterocyclic Chlorides with Arylmagnesium Halides and Polyfunctionalized Arylcopper Reagents Aryl Bromides, Chlorides, Fluorides TosylatesSynthesis 2006; 2006(24): 4270-4270DOI: 10.1055/s-2006-950377
Correction to: Cobalt-Catalyzed Cross-Coupling Reactions of Heterocyclic Chlorides with Arylmagnesium Halides and Polyfunctionalized Arylcopper Reagents Aryl Bromides, Chlorides, Fluorides TosylatesSynthesis 2006; 2006(21): 3547-3574DOI: 10.1055/s-2006-950290
ABSTRACT Orthohantaviruses, are emerging zoonotic pathogens causing life-threatening diseases in humans. The orthohantavirus genome consists of three RNA segment (vRNAs) negative polarity, which encapsidated by the viral nucleoprotein (N). To date, precise subcellular behavior vRNAs and N has not been fully elucidated. Here, we present a comprehensive analysis infections using Fluorescence situ Hybridization (FISH) multiple sequential FISH (Mu-Seq FISH), enables simultaneous detection RNAs,...
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