A5006881317- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Fire effects on ecosystems
- Vector-Borne Animal Diseases
- Mosquito-borne diseases and control
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Plant Virus Research Studies
- Bat Biology and Ecology Studies
- Respiratory viral infections research
- Influenza Virus Research Studies
- Aquaculture disease management and microbiota
- Parvovirus B19 Infection Studies
- Aquaculture Nutrition and Growth
- Toxin Mechanisms and Immunotoxins
- Virology and Viral Diseases
- Poxvirus research and outbreaks
- RNA and protein synthesis mechanisms
- Viral Infectious Diseases and Gene Expression in Insects
- COVID-19 epidemiological studies
- Viral Infections and Immunology Research
- Animal Virus Infections Studies
- Xenotransplantation and immune response
- Transgenic Plants and Applications
- Animal health and immunology
Charité - Universitätsmedizin Berlin
2012-2024
Humboldt-Universität zu Berlin
2020-2022
MSB Medical School Berlin
2012-2020
Freie Universität Berlin
2020
Chumakov Institute of Poliomyelitis and Viral Encephalitides
2015
Samara State Medical University
2015
Rostov-on-Don Anti-plague Institute Rospotrebnadzor
2015
Slovak Academy of Sciences
2015
University of California, Irvine
2015
Takeda (Japan)
2015
We have discovered the first indigenous African hantavirus, Sangassou virus (SANGV). The was isolated from an wood mouse (Hylomyscus simus), trapped in a forest habitat Guinea, West Africa. Here, we report on characterization of genetic and functional properties virus. complete genome SANGV determined showed typical hantavirus organization. small (S), medium (M), large (L) segments containing genes encoding nucleocapsid protein, two envelope glycoproteins, viral polymerase were found to be...
Various hantaviruses have been discovered in unconventional hosts (shrews and bats) Africa. Up to now, it was unknown whether these viruses pose a threat for human health. In this study, using newly established serological assays, we demonstrated evidence of shrew-borne hantavirus infections humans from Côte d'Ivoire Gabon.
Background: Hantaviruses are zoonotic agents that cause hemorrhagic fevers and thought to be transmitted humans by exposure aerosolized excreta of infected rodents. Puumala virus (PUUV) is the predominant endemic hantavirus in Europe. A large proportion PUUV-infected patients suffer from gastrointestinal symptoms unclear origin. In this study we demonstrate PUUV infection can occur via alimentary tract. Methods: We investigated susceptibility human small intestinal epithelium for analyzed...
Background Dobrava-Belgrade virus (DOBV) is a European hantavirus causing hemorrhagic fever with renal syndrome (HFRS) in humans fatality rates of up to 12%. DOBV-associated clinical cases typically occur also the northern part Germany where carried by striped field mouse (Apodemus agrarius). However, causative agent responsible for human illness has not been previously isolated. Methodology/Principal Findings Here we report on characterization novel cell culture isolate from obtained lung...
Hantaviruses are zoonotic viruses with a complex evolutionary history of virus–host coevolution and cross-species transmission. Although hantaviruses have broad reservoir host range, relationships were previously thought to be strict, single virus species infecting species. Here, we describe Bruges virus, novel hantavirus harbored by the European mole (Talpa europaea), which is well-known Nova virus. Phylogenetic analyses all three genomic segments showed tree topology inconsistencies,...
The family Hantaviridae comprises a diverse group of virus species and is considered an emerging global public health threat. Individual hantavirus differ considerably in terms their pathogenicity but also cell biology host-pathogen interactions. In this study, we focused on the most prevalent pathogenic Europe, Puumala (PUUV), investigated entry internalization PUUV into mammalian cells. We show that both clathrin-mediated endocytosis macropinocytosis are cellular pathways exploited by to...
Sochi virus, a novel genetic variant of Dobrava-Belgrade was isolated in cell culture from fulminant lethal case hantavirus disease presenting with shock and combined kidney lung failure. virus is transmitted to humans host reservoir Apodemus ponticus must be considered life-threatening emerging agent.
Hantaviruses are emerging zoonotic pathogens that can cause severe disease in humans. Clinical observations suggest human immune components contribute to hantavirus-induced pathology. To address this issue we generated mice with a humanized system. Hantavirus infection of these animals resulted systemic associated weight loss, decreased activity, ruffled fur and inflammatory infiltrates lung tissue. Intriguingly, after infection, harbouring leukocyte antigen (HLA) class I-restricted CD8+ T...
A novel hantavirus, named Kiwira virus, was molecularly detected in six Angolan free-tailed bats (Mops condylurus, family Molossidae) captured Tanzania and one bat the Democratic Republic of Congo. Hantavirus RNA found different organs, with highest loads spleen. Nucleotide sequences large parts genomic S L segments were determined by in-solution hybridisation capture high throughput sequencing. Phylogenetic analyses placed virus into genus Mobatvirus Hantaviridae, bat-infecting Quezon...
Sochi virus was recently identified as a new hantavirus genotype carried by the Black Sea field mouse, Apodemus ponticus. We evaluated 62 patients in Russia with infection. Most clinical cases were severe, and case-fatality rate high 14.5%.
Hantaviruses are members of the Bunyaviridae family carried by small mammals and causing human hemorrhagic fevers worldwide. In Western Africa, where a variety fever viruses occurs, indigenous hantaviruses have been molecularly found in animal reservoirs such as rodents, shrews, bats since 2006. To investigate contact to these hosts assess public health relevance for humans living tropical rainforest regions Central we performed cross-sectional seroprevalence study region Taï National Park...
Arenaviruses are feared as agents that cause viral hemorrhagic fevers. We report the identification, isolation, and genetic characterization of 2 novel arenaviruses from Namaqua rock mice in Namibia. These findings extend knowledge distribution diversity Africa.
Hantavirus disease belongs to the emerging infections. The clinical picture and severity of infections differ between hantavirus species may even vary genotypes. mechanisms that lead broad variance in infected patients are not completely understood. Host- virus-specific factors considered. We analyzed severe cases two young women. first case was caused by Puumala virus (PUUV) infection Germany; second describes with Dobrava-Belgrade (DOBV) Russia. Symptoms, laboratory parameters cytokine...
Surveillance of highly pathogenic viruses circulating in both human and animal populations is crucial to unveil endemic infections potential zoonotic reservoirs. Monitoring the burden disease by serological assay could be used as an early warning system for imminent outbreaks increased seroprevalance often precedes larger outbreaks. However, multitude necessitates need identify specific antibodies against several targets from humans well reservoir animals such bats. In order address this, we...
The influenza A virus (IAV) genome is segmented into eight viral ribonucleoproteins, each expressing a negatively oriented RNA (vRNA). Along the infection cycle, highly abundant single-stranded small RNAs (svRNA) are transcribed in segment-specific manner. sequences of svRNAs and vRNA 5'-ends identical conserved among all IAV strains. Here, we demonstrate that these can be used as target for pan-selective sensor infection. To this end, complementary fluorescent forced-intercalation (IAV...