A5063711068- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- TGF-β signaling in diseases
- Mosquito-borne diseases and control
- Vector-Borne Animal Diseases
- Hippo pathway signaling and YAP/TAZ
- Cancer-related gene regulation
- Metabolism, Diabetes, and Cancer
- Protein Structure and Dynamics
- RNA modifications and cancer
- Viral Infections and Immunology Research
- Autophagy in Disease and Therapy
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- NF-κB Signaling Pathways
- Parvovirus B19 Infection Studies
The Francis Crick Institute
2022-2025
University of Leeds
2015-2020
Institute of Structural and Molecular Biology
2015
ATG9A and ATG2A are essential core members of the autophagy machinery. is a lipid scramblase that allows equilibration lipids across membrane bilayer, whereas facilitates flow between tethered membranes. Although both have been functionally linked during formation autophagosomes, molecular details consequences their interaction remain unclear. By combining data from peptide arrays, crosslinking, hydrogen-deuterium exchange mass spectrometry together with cryoelectron microscopy, we propose...
Hazara virus (HAZV) is a member of the Bunyaviridae family segmented negative stranded RNA viruses, and shares same serogroup as Crimean-Congo haemorrhagic fever (CCHFV). CCHFV responsible for fatal human disease with mortality rate approaching 30 %, which has an increased recent incidence within southern Europe. There are no preventative or therapeutic treatments CCHFV-mediated disease, thus classified hazard group 4 pathogen. In contrast HAZV not associated serious although infection...
Surveillance of highly pathogenic viruses circulating in both human and animal populations is crucial to unveil endemic infections potential zoonotic reservoirs. Monitoring the burden disease by serological assay could be used as an early warning system for imminent outbreaks increased seroprevalance often precedes larger outbreaks. However, multitude necessitates need identify specific antibodies against several targets from humans well reservoir animals such bats. In order address this, we...
Betaglycan (BG) is a transmembrane co-receptor of the transforming growth factor-β (TGF-β) family signaling ligands. It essential for embryonic development and tissue homeostasis fertility in adults. functions by enabling binding three TGF-β isoforms to their receptors additionally required inhibin A (InhA) activity. Despite its requirement TGF-βs InhA vivo, structural information explaining BG ligand selectivity mechanism action lacking. Here, we determine structure bound both receptors,...
The Bunyavirales order are the largest group of negative stranded RNA viruses, infecting humans as well a bewildering array animals and plants, in which select members cause severe or fatal disease. To enter host cells, bunyaviruses undergo endosomal transport to specific cellular destinations exploit changing environment maturing endocytic vesicles mediate genome release. Several virus-endosome fusion triggers have previously been identified, including potassium (K+) recently identified by...