A5023618276- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Advances in Oncology and Radiotherapy
- Lung Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Prostate Cancer Diagnosis and Treatment
- Effects of Radiation Exposure
- Endometrial and Cervical Cancer Treatments
- Lung Cancer Treatments and Mutations
- Shoulder Injury and Treatment
- Diversity and Career in Medicine
- Muscle Physiology and Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Shoulder and Clavicle Injuries
- Cancer-related molecular mechanisms research
- Medical research and treatments
- Pelvic and Acetabular Injuries
- Muscle activation and electromyography studies
- COVID-19 and healthcare impacts
- Cardiomyopathy and Myosin Studies
- Ultrasound in Clinical Applications
Loyola University Chicago
2021-2024
Dr. D. Y. Patil Medical College, Hospital and Research Centre
2024
Loyola University Medical Center
2021-2023
Radiation Oncology Associates
2023
Edward Hines, Jr. VA Hospital
2023
University of Michigan
2013-2019
Michigan Medicine
2018
Abstract A challenge in oncology is to rationally and effectively integrate immunotherapy with traditional modalities, including radiotherapy. Here, we demonstrate that radiotherapy induces tumor-cell ferroptosis. Ferroptosis agonists augment ferroptosis antagonists limit efficacy tumor models. Immunotherapy sensitizes tumors by promoting Mechanistically, IFNγ derived from immunotherapy-activated CD8+ T cells radiotherapy-activated ATM independently, yet synergistically, suppresses SLC7A11,...
Background: The repair and restoration of function after chronic rotator cuff tears are often complicated by muscle atrophy, fibrosis, fatty degeneration the diseased muscle. inflammatory response has been implicated in development injuries. Licofelone is a novel anti-inflammatory drug that inhibits 5-lipoxygenase (5-LOX), as well cyclooxygenase (COX)–1 COX-2 enzymes, which play important roles inducing inflammation While previous studies have demonstrated nonsteroidal drugs selective...
Abstract Background We sought to investigate the prognostic value of volumetric positron emission tomography (PET) parameters in patients with human papillomavirus (HPV)‐related oropharyngeal squamous cell carcinoma (OPSCC) and a ≤10 pack‐year smoking history treated chemoradiation. Methods A total 142 were included. Maximum standardized uptake value, metabolic tumor volume, lesion glycolysis (TLG) primary tumor, involved regional lymph nodes, calculated. Cox proportional hazard modeling was...
Objective. Both computed tomography (CT) and magnetic resonance imaging (MRI) images are acquired for high-dose-rate (HDR) prostate brachytherapy patients at our institution. CT is used to identify catheters MRI segment the prostate. To address scenarios of limited access, we developed a novel generative adversarial network (GAN) generate synthetic (sMRI) from with sufficient soft-tissue contrast provide accurate segmentation without (rMRI).Approach. Our hybrid GAN, PxCGAN, was trained...
Background: Liver tumors are commonly encountered in oncology. The study aimed to assess the impact of magnetic resonance imaging (MRI)-guided stereotactic body radiation therapy (SBRT) (MRgSBRT) on disease-related outcomes and toxicity profile. Methods: Patients who received MRgSBRT from 2019 2021 for primary metastatic liver were included this analysis. protocol treatment simulation Gadoxetate disodium injection followed by a single-dimensional post-exhale MRI (0.35-T linear accelerator)...
Introduction-Pleural empyema (PE) is an infectious condition of the pleural cavity. The most frequent cause PE pneumonia, when a preexisting parapneumonic effusion gets superinfected by bacteria, often due to perforation subpleural pulmonary abscess. Lung isolation not always necessary in paediatric population and procedures can be done with conventional tracheal intubation. Methods – we report case 1year old male diagnosed fibrosis right upper lower lobe posted for decortication. Patient...
Skeletal muscle contraction results from molecular interactions of myosin "crossbridges" with adjacent actin filament binding sites. The to can be "weak" or "strong," and only strong states contribute force production. During active shortening, the number strongly bound crossbridges declines increasing shortening velocity. Forcibly stretching a that is actively at high velocity in no apparent negative consequences, whereas stretch an isometrically (fixed-length) contracting causes...
Purpose: To evaluate the frequency of and reasons for patient callback from offline screening mammography, comparing residents breast imaging faculty.Methods: Residents MQSA-approved fellowship-trained faculty independently recorded prospective interpretations a subset bilateral clinical mammograms performed over 1-year period at our NCI-designated cancer site utilizing Computer-Assisted Diagnosis (CAD).BI-RADS 1, 2, or 0 were allowed screen interpretation.IRB-approved retrospective review...
<div>Abstract<p>A challenge in oncology is to rationally and effectively integrate immunotherapy with traditional modalities, including radiotherapy. Here, we demonstrate that radiotherapy induces tumor-cell ferroptosis. Ferroptosis agonists augment ferroptosis antagonists limit efficacy tumor models. Immunotherapy sensitizes tumors by promoting Mechanistically, IFNγ derived from immunotherapy-activated CD8<sup>+</sup> T cells radiotherapy-activated ATM independently,...
<p>Figure S4 shows that radiotherapy and immunotherapy can synergistically induce tumoral ferroptosis</p>
<p>Table S1 shows the information on antagonists and agonists used in this study</p>
<p>Figure S1 shows that radiotherapy can induce tumor cell ferroptosis</p>