A5007202398- Cystic Fibrosis Research Advances
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Respiratory and Cough-Related Research
- Respiratory viral infections research
- Tracheal and airway disorders
- Childhood Cancer Survivors' Quality of Life
- Neonatal Respiratory Health Research
- Transcranial Magnetic Stimulation Studies
- Pain Management and Treatment
- Delphi Technique in Research
- Pediatric health and respiratory diseases
- Shoulder Injury and Treatment
- Pain Mechanisms and Treatments
- Adolescent and Pediatric Healthcare
- Inhalation and Respiratory Drug Delivery
- Child Nutrition and Feeding Issues
- Shoulder and Clavicle Injuries
- Family and Patient Care in Intensive Care Units
- Cardiovascular Syncope and Autonomic Disorders
- Family and Disability Support Research
- Schizophrenia research and treatment
- Pneumonia and Respiratory Infections
- Dysphagia Assessment and Management
Edge Hill University
2015-2024
Birmingham Women’s and Children’s NHS Foundation Trust
2022
Lancaster University
2010-2021
Innovation Team (China)
2000-2018
Brunel University of London
2004-2010
RMIT University
2010
Cliniques Universitaires Saint-Luc
2007
St George's, University of London
2001-2003
St George's Hospital
2001-2003
<h3>Abstract</h3> <b>Objectives:</b> To determine the effect of long term inhaled corticosteroids on lung function, exacerbations, and health status in patients with moderate to severe chronic obstructive pulmonary disease. <b>Design:</b> Double blind, placebo controlled study. <b>Setting:</b> Eighteen UK hospitals. <b>Participants:</b> 751 men women aged between 40 75 years mean forced expiratory volume one second (FEV<sub>1</sub>) 50% predicted normal. <b>Interventions:</b> Inhaled...
Exacerbations of chronic obstuctive pulmonary disease (COPD) are associated with worse health status. The Inhaled Steroids in Obstructive Lung Disease Europe (ISOLDE) study showed that treatment fluticasone propionate (FP) reduced exacerbation frequency and the rate deterioration status as compared placebo. present analysed these data to test whether effect FP on was attributable its exacerbations. Rates St George's Respiratory Questionnaire (SGRQ) total score were obtained for 613 patients...
BackgroundManipulation under anaesthesia and arthroscopic capsular release are costly invasive treatments for frozen shoulder, but their effectiveness remains uncertain. We compared these two surgical interventions with early structured physiotherapy plus steroid injection.MethodsIn this multicentre, pragmatic, three-arm, superiority randomised trial, patients referred to secondary care treatment of primary shoulder were recruited from 35 hospital sites in the UK. Participants adults (≥18...
The magnitude and time course of effect an acute exacerbation chronic bronchitis (AECB) on health status are not known. Data from the GLOBE study, a randomised double blind trial antibiotic therapy, were used to investigate these effects.438 patients with AECB received either gemifloxacin 320 mg once daily for 5 days (214 patients) or clarithromycin 500 twice 7 (224 followed up 26 weeks. St George's Respiratory Questionnaire (SGRQ) scores obtained at baseline after 4, 12, weeks.At...
This study examined health status decline in patients with chronic obstructive pulmonary disease (COPD). Data are from the Inhaled Steroids Obstructive Lung Disease (ISOLDE) trial. After an 8-wk run-in, 751 (566 male), mean age 64 yr, were randomized to receive fluticasone propionate (FP) 500 μ g twice daily (376 patients) or placebo (375 patients). Mean baseline postbronchodilator FEV1 was 50 ± 15% predicted. Patients completed St George's Respiratory Questionnaire (SGRQ) and Short-Form 36...
Citation screening is a labour-intensive part of the process systematic literature review that identifies citations eligible for inclusion in review. In this paper, we present an automatic text classification approach aims to prioritise earlier than ineligible ones and thus reduces manual labelling effort involved process. e.g. by automatically excluding lower ranked citations. To improve performance classifier, develop novel neural network-based feature extraction method. Unlike previous...
Background Frozen shoulder causes pain and stiffness. It affects around 10% of people in their fifties is slightly more common women. Costly invasive surgical interventions are used, without high-quality evidence that these effective. Objectives To compare the clinical effectiveness cost-effectiveness three treatments secondary care for adults with frozen shoulder; to qualitatively explore acceptability patients health-care professionals; update a systematic review trial findings context...
Frozen shoulder (also known as adhesive capsulitis) occurs when the capsule, or soft tissue envelope around ball and socket joint, becomes scarred contracted, making tight, painful stiff. It affects 1 in 12 men 10 women of working age. Although this condition can settle with time (typically taking to 3 years), for some people it causes severe symptoms needs referral hospital. Our aim is evaluate clinical cost-effectiveness two invasive costly surgical interventions that are commonly used...
Background Bronchiectasis is a chronic respiratory condition that impacts significantly on individuals and healthcare services. Self-management recommended in clinical guidelines for bronchiectasis as an intervention to enable patients manage their condition, yet there little evidence support it. Methods Three face focus groups (17 adults with bronchiectasis) were conducted at three National Health Service (NHS) sites North West England. Additionally, semi-structured telephone interviews...