A5085609995- Renal Transplantation Outcomes and Treatments
- T-cell and B-cell Immunology
- Shoulder Injury and Treatment
- Orthopaedic implants and arthroplasty
- Hip disorders and treatments
- Transplantation: Methods and Outcomes
- Immune Cell Function and Interaction
- Total Knee Arthroplasty Outcomes
- Organ Transplantation Techniques and Outcomes
- Soil and Unsaturated Flow
- Knee injuries and reconstruction techniques
- Musculoskeletal synovial abnormalities and treatments
- Shoulder and Clavicle Injuries
- Innovations in Medical Education
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- Periodontal Regeneration and Treatments
- Orthopedic Surgery and Rehabilitation
- Elbow and Forearm Trauma Treatment
- Clinical Reasoning and Diagnostic Skills
- Nerve Injury and Rehabilitation
- Tendon Structure and Treatment
- Orthopedic Infections and Treatments
- Global Health Workforce Issues
- Patient Satisfaction in Healthcare
University of Virginia
2023-2024
Case Western Reserve University
2014-2024
Steadman Philippon Research Institute
2022-2024
Steadman Clinic
2022-2024
University School
2014-2023
Regional Medical Center
2023
Cleveland Clinic Lerner College of Medicine
2014-2023
Sante Montreal
2023
University Hospitals of Cleveland
2018-2022
University of Ottawa
2014-2022
Abstract Chronic conditions associated with aging have proven difficult to prevent or treat. Senescence is a cell fate defined by loss of proliferative capacity and the development pro‐inflammatory senescence‐associated secretory phenotype comprised cytokines/chemokines, proteases, other factors that promotes age‐related diseases. Specifically, an increase in senescent peripheral blood mononuclear cells (PBMCs), including T cells, like frailty, rheumatoid arthritis, bone loss. However, it...
Differences in levels of environmentally induced memory T cells that cross-react with donor MHC molecules are postulated to account for the efficacy allograft tolerance-inducing strategies rodents versus their failure nonhuman primates and human transplant patients. Strategies study impact donor-reactive on allografts have relied pretransplant induction cross-reactive allogeneic through recipient viral infection, priming directly antigen or adoptive transfer primed cells. Each approach...
Study Design. Cross-sectional study. Objective. To determine whether there is an association between body mass index (BMI) and the prevalence, severity, frequency of low back pain identify other potential patient risk factors for development pain. Summary Background Data. Many studies have implicated that a high BMI factor However, few examined increased Methods. Data from Osteoarthritis Initiative, multicenter, prospective study knee osteoarthritis, were used to conduct this study, which...
Orthobiologics encompass numerous substances that are naturally found in the human body including platelet-rich plasma (PRP), isolated growth factors, and cell therapy approaches to theoretically optimize improve healing of cartilage, fractures, injured muscles, tendons, ligaments.PRP is an autologous derivative whole blood generated by centrifugation perhaps most widely used orthobiologic treatment modality. Despite a vast amount literature on its use osteoarthritis as well tendon ligament...
Abstract Background Identifying ideal candidates for orthopaedic surgery residency is difficult. Data available applicant selection are evolving; preclinical grades and the Alpha Omega (AOA) honors society being phased out at some medical schools. Similarly, three-digit United States Medical Licensing Examination (USMLE) Step 1 scores have been eliminated. There renewed interest in improving resident to provide a diverse, comprehensive educational opportunity that produces surgeons who...
The pathogenic role of macrophages in antibody-mediated rejection (AMR) remains unclear. Monocyte chemoattractant protein-1 (MCP-1/CCL2) is a potent chemotactic factor for monocytes and macrophages. current studies used murine model AMR to investigate the graft-derived CCL2 how may participate allograft injury. B6.CCR5−/−/CD8−/− recipients rejected MHC-mismatched WT A/J allografts with high donor-reactive antibody titers diffuse C4d deposition large vessels myocardial capillaries, features...
Objectives Currently, a 'pedagogical gap' exists in distributed medical education that distance educators teach students but typically do not have the opportunity to assess them large-scale examinations such as objective structured clinical examination (OSCE). We developed remote examiner OSCE (reOSCE) was integrated into traditional establish whether technology may be used bridge this gap. The purpose of study explore physician-examiners can replace on-site an OSCE, and determine...
Abstract In inflamed lymph nodes, Ag-specific CD4+ and CD8+ T cells encounter Ag-bearing dendritic and, together, this complex enhances the release of CCL3 CCL4, which facilitate additional interaction with naive cells. Although blocking CCL4 has no effect on primary cell responses, it dramatically impairs development memory upon Ag rechallenge. Despite absence detectable surface CCR5 expression circulating native cells, these data imply that are capable expressing prior to cognate...
The Notch pathway is an extensively utilized, evolutionarily maintained regulatory system which mediates a wide range of fate decisions among multipotent precursor cells by inhibiting differentiation along one while promoting self-renewal or alternative pathway. signaling has been shown to affect haematopoietic stem cell (HSC) and differentiation, T versus B specification, myeloid differentiation. diverse functions in vertebrates are facilitated complex in-teractions between four receptors...
A method for rapidly obtaining water retention data soils is presented. variation of the Richard's pressure cell used in which equilibrium at a particular content achieved by adjustment outflow pressure, rather than permitting to be reached fixed increment pressure. On wetting cycle, added directly sample being imbibed through capillary barrier. The result that on both and drying cycles can obtained small fraction time needed conventional procedures. Consistent fit smooth curve have been...
Recipient endogenous memory T cells with donor reactivity pose an important barrier to successful transplantation and costimulatory blockade-induced graft tolerance. Longer ischemic storage times prior organ increase early posttransplant inflammation negatively impact function long-term outcome. Little is known about the mechanisms enhancing cell activation mediate tissue injury within increased inflammatory environment of allografts subjected prolonged cold (CIS). Endogenous CD4+ CD8+...
Abstract Reperfusion of organ allografts induces a potent inflammatory response that directs rapid memory T cell, neutrophil, and macrophage graft infiltration their activation to express functions mediating tissue injury. The role cardiac allograft IL-1 receptor (IL-1R) signaling in this early inflammation the downstream primary alloimmune was investigated. When compared with complete MHC-mismatched wild-type allografts, IL-1R−/− had marked decreases endogenous CD8 cell neutrophil...