A5101568199- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Virology and Viral Diseases
- Memory and Neural Mechanisms
- Animal Virus Infections Studies
- Neuroscience and Neural Engineering
- Microfluidic and Bio-sensing Technologies
- Viral Infections and Immunology Research
- 3D Printing in Biomedical Research
University of California, San Diego
2025
Consejo Nacional de Investigaciones Científicas y Técnicas
2014-2016
Fundación Instituto Leloir
2005-2016
Integration of adult-born brain cells Physical exercise or exploration a novel environment greatly influences the production, maturation, and connectivity neurons. Alvarez et al. investigated how experience affects incorporation neurons into hippocampal network. A brief period sensory enrichment when new were 9 to 10 days old led having larger dendrites more functional spine synapses. disynaptic preexisting feedback circuit promoted growth integration cells. Science , this issue p. 459
Abstract Intracellular electrophysiology is essential in neuroscience, cardiology, and pharmacology for studying cells’ electrical properties. Traditional methods like patch-clamp are precise but low-throughput invasive. Nanoelectrode Arrays (NEAs) offer a promising alternative by enabling simultaneous intracellular extracellular action potential (iAP eAP) recordings with high throughput. However, accessing potentials NEAs remains challenging. This study presents an AI-supported technique...
Newly generated dentate granule cells (GCs) are relevant for input discrimination in the adult hippocampus. Yet, their precise contribution to information processing remains unclear. To address this question, it is essential develop approaches precisely label entire cohorts of adult-born GCs. In work, we used genetically modified mice allow conditional expression tdTomato (Tom) GCs and characterized development functional integration. Ascl1 CreERT2 ;CAG floxStopTom Glast resulted indelible...
Triatoma virus (TrV) belongs to a new family of RNA viruses known as Dicistroviridae. Nucleotide sequence comparisons between different dicistroviruses allowed two putative internal ribosomal entry sites (IRESs) in the TrV be defined: 5'UTR IRES 548 nt and intergenic region (IGR) 172 nt. Using monocistronic bicistronic RNAs, it was shown that genome contains functional IRESs mediate translation initiation cap-independent manner. In addition, found were able direct efficient reporter genes...