A5017199191- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Autism Spectrum Disorder Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Neurotoxicity Research
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Genetics and Neurodevelopmental Disorders
- Single-cell and spatial transcriptomics
- Neurobiology and Insect Physiology Research
- RNA Research and Splicing
- CRISPR and Genetic Engineering
- Photoreceptor and optogenetics research
- Child Nutrition and Feeding Issues
- Axon Guidance and Neuronal Signaling
- Nerve injury and regeneration
- Neuroscience and Neural Engineering
- Attention Deficit Hyperactivity Disorder
- Intensive Care Unit Cognitive Disorders
- Bioinformatics and Genomic Networks
- bioluminescence and chemiluminescence research
- Phosphodiesterase function and regulation
- Ion channel regulation and function
- Boron Compounds in Chemistry
- Protein Degradation and Inhibitors
Harvard University
2017-2023
Sumitomo Dainippon Pharma (United States)
2023
Broad Institute
2021-2023
Fundación Instituto Leloir
2014-2020
University of Virginia
2019
Korea Health Industry Development Institute
2019
Konkuk University
2013-2018
Seoul National University
2018
Consejo Nacional de Investigaciones Científicas y Técnicas
2014-2016
University of Buenos Aires
2008-2012
Integration of adult-born brain cells Physical exercise or exploration a novel environment greatly influences the production, maturation, and connectivity neurons. Alvarez et al. investigated how experience affects incorporation neurons into hippocampal network. A brief period sensory enrichment when new were 9 to 10 days old led having larger dendrites more functional spine synapses. disynaptic preexisting feedback circuit promoted growth integration cells. Science , this issue p. 459
Abstract Autism spectrum disorder (ASD) is a heterogeneously pervasive developmental in which various genetic and environmental factors are believed to underlie its development. Recently, epigenetics has been suggested as novel concept for ASD aetiology with proposition that epigenetic marks can be transgenerationally inherited. Based on this assumption of epigenetics, we investigated the transgenerational inheritance ASD-like behaviours their related synaptic changes VPA animal model ASD....
Autism spectrum disorder (ASD) is a group of pervasive developmental disorders with core symptoms such as sociability deficit, language impairment, and repetitive/restricted behaviors. Although worldwide prevalence ASD has been increased continuously, therapeutic agents to ameliorate the especially social deficits, are very limited. In this study, we investigated potential donepezil for using valproic acid-induced autistic animal model (VPA model). We found that prenatal exposure acid (VPA)...
Cellular effects of visual deprivation Myelination speeds the progress action potentials along neuronal axons. Yang et al. studied changes in myelination mouse cortex response to experience (see Perspective by Yalçin and Monje). With normal vision, is continuously remodeled. As ocular dominance shifts monocular deprivation, patterns change on certain inhibitory interneurons but not excitatory callosal projection neurons. Myelin sheaths are both added subtracted, segments myelin elongate...
Triclosan is an antimicrobial or sanitizing agent used in personal care and household products such as toothpaste, soaps, mouthwashes kitchen utensils.There are increasing evidence of the potentially harmful effects triclosan many systemic cellular processes body.In this study, we investigated survivability cultured rat neural stem cells (NSCs).Cortical from embryonic day 14 embryos were isolated vitro.After stabilizing culture, was introduced to with concentrations ranging 1 μM 50 varied...
A strong GABAergic tone imposes sparse levels of activity in the dentate gyrus hippocampus. This balance is challenged by addition new granule cells (GCs) with high excitability. How developing GCs integrate within local inhibitory networks remains unknown. We used optogenetics to study synaptogenesis between and interneurons expressing parvalbumin (PV-INs) somatostatin (SST-INs). PV-INs target soma, synapses become mature after 6 weeks. transition accelerated exposure an enriched...
Newly generated dentate granule cells (GCs) are relevant for input discrimination in the adult hippocampus. Yet, their precise contribution to information processing remains unclear. To address this question, it is essential develop approaches precisely label entire cohorts of adult-born GCs. In work, we used genetically modified mice allow conditional expression tdTomato (Tom) GCs and characterized development functional integration. Ascl1 CreERT2 ;CAG floxStopTom Glast resulted indelible...
De novo heterozygous loss-of-function mutations in phosphatase and tensin homolog (PTEN) are strongly associated with autism spectrum disorders; however, it is unclear how this gene affect different cell types during human brain development these effects vary across individuals. Here, we used cortical organoids from donors to identify cell-type specific developmental events that affected by PTEN. We profiled individual single-cell RNA-seq, proteomics spatial transcriptomics revealed...
Propofol is an anesthetic agent that gained wide use because of its fast induction anesthesia and rapid recovery post-anesthesia. However, previous studies have reported immediate neurodegeneration long-term impairment in spatial learning memory from repeated neonatal propofol administration animals. Yet, none those has explored the sex-specific physical changes behavioral alterations such as social (sociability preference), emotional (anxiety), other cognitive functions (spatial working,...
Abstract Aberrant dopaminergic and glutamatergic function, particularly within the striatum hippocampus, has repeatedly been associated with pathophysiology of schizophrenia. Supported by preclinical recent clinical data, trace amine-associated receptor 1 (TAAR1) agonism emerged as a potential new treatment approach for While current evidence implicates TAAR1-mediated regulation tone primary circuit mechanism, little is known about effects TAAR1 agonists on system excitation-inhibition...
A substantial proportion of patients with autism spectrum disorder (ASD) display hyperactivity as a comorbid symptom.Exposure to valproic acid (VPA) during pregnancy produces ASD-like core behavioral phenotypes well in offspring both human and experimental animals, which makes it plausible model study ASD-related neurobiological processes.In this study, we examined the effects two currently available attention defecit (ADHD) medications, methylphenidate (MPH) atomoxetine (ATX) targeting...
Benzalkonium chloride, diazolidinyl urea, and imidazolidinyl urea are commonly used preservatives in cosmetics. Recent reports suggested that these compounds may have cellular systemic toxicity high concentration. In addition, known formaldehyde (FA) releasers, raising concerns for cosmetic preservatives. this study, we investigated the effects of benzalkonium on ROS-dependent apoptosis rat neural progenitor cells (NPCs) vitro. Cells were isolated cultured from embryonic day 14 cortices....
Autism spectrum disorder (ASD) remains unexplained and untreated despite the high attention of research in recent years.Aside from its various characteristics is baffling male preponderance over female population.Using a validated animal model ASD which telomerase reverse transcriptase overexpressing mice (TERT-tg), we conducted ASD-related behavioral assessments protein expression experiments to mark difference between females this model.After statistically analyzing results, found...
Signal processing in neuritic trees is ruled by the concerted action of passive and active membrane properties that, together, determine degree electrical compartmentalization these trees. We analyzed how modulate spatial propagation graded signals a pair nonspiking (NS) neurons leech. NS present very extensive tree that mediates interaction with all excitatory motoneurons leech ganglia. cells express voltage-activated Ca 2+ conductances (VACCs) under certain experimental conditions, evoke...