A5103172231- Plant-Microbe Interactions and Immunity
- Plant Molecular Biology Research
- Single-cell and spatial transcriptomics
- Erythrocyte Function and Pathophysiology
- Retinal Development and Disorders
- CRISPR and Genetic Engineering
- Molecular Biology Techniques and Applications
- Cancer-related Molecular Pathways
- Ethics in Clinical Research
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Congenital heart defects research
- Plant Stress Responses and Tolerance
- Metabolomics and Mass Spectrometry Studies
- Plant Parasitism and Resistance
- Ocular Oncology and Treatments
- Ion channel regulation and function
- Caveolin-1 and cellular processes
Indiana University School of Medicine
2023
Indiana University – Purdue University Indianapolis
2023
University of California, Irvine
2022
Harvard University
2020-2022
University of Missouri
2020-2021
Broad Institute
2020
Mechanical forces and tissue mechanics influence the morphology of developing brain, but underlying molecular mechanisms have been elusive. Here, we examine role mechanotransduction in brain development by focusing on Piezo1, a mechanically activated ion channel. We find that Piezo1 deletion results thinner neuroepithelial layer, disrupts pseudostratification, reduces neurogenesis E10.5 mouse embryos. Proliferation differentiation knockout (KO) neural stem cells (NSCs) isolated from embryos...
Regulation of the plant immune system is important for controlling specificity and amplitude responses to pathogens in preventing growth-inhibiting autoimmunity that leads reductions fitness. In previous work, we reported SRFR1, a negative regulator effector-triggered immunity, interacts with SNC1 EDS1. When SRFR1 non-functional Arabidopsis accession Col-0, levels increase, causing cascade events lead phenotypes. Previous work showed some members transcriptional co-repressor family TOPLESS...
ABSTRACT Genetic risk for autism spectrum disorder (ASD) has been associated with hundreds of genes spanning a wide range biological functions. The phenotypic alterations in the human brain resulting from mutations ASD remain unclear, and level at which these converge on shared disease pathology is poorly understood. Here, we leveraged reproducible organoid models cerebral cortex to identify cell type-specific developmental abnormalities haploinsufficiency three genes, SUV420H1 ( KMT5B ),...
Abstract Background The National Centralized Repository for Alzheimer’s Disease and Related Dementias (NCRAD) was established in 1990 at Indiana University with the mission to support research focused on etiology, early detection, development of therapeutics ADRD. NCRAD has been funded by Institute Aging (NIA) since is an integral international resource clinical information biological materials. As ADRD advanced, NIA have worked together expand number type specimens available community....
Abstract Regulation of the plant immune system is important for controlling specificity and amplitude responses to pathogens in preventing growth-inhibiting autoimmunity that leads reductions fitness. In previous work, we reported SRFR1, a negative regulator effector-triggered immunity, interacts with SNC1 EDS1. When SRFR1 non-functional Arabidopsis accession Col-0, levels increase, causing cascade events lead phenotypes. Previous work showed some members transcriptional co-repressor family...