A5006776652- Signaling Pathways in Disease
- RNA Research and Splicing
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Spaceflight effects on biology
- Genomics and Chromatin Dynamics
- RNA and protein synthesis mechanisms
- High Altitude and Hypoxia
- Histone Deacetylase Inhibitors Research
- Axon Guidance and Neuronal Signaling
- Cellular transport and secretion
- Advanced NMR Techniques and Applications
- Advanced Chemical Physics Studies
- Corneal surgery and disorders
- Protein Structure and Dynamics
- Calpain Protease Function and Regulation
- NF-κB Signaling Pathways
- Inorganic Fluorides and Related Compounds
- Genetics and Neurodevelopmental Disorders
- Pluripotent Stem Cells Research
- Hippo pathway signaling and YAP/TAZ
- CRISPR and Genetic Engineering
- Advanced Vision and Imaging
- Nuclear Receptors and Signaling
- Single-cell and spatial transcriptomics
Tri-Institutional PhD Program in Chemical Biology
2022-2025
Cornell University
2024-2025
University of Southern California
2020-2024
Broad Center
2020-2024
Leibniz University Hannover
2024
Rockefeller University
2022
Southern California University for Professional Studies
2022
Forest Industry Research Institute
2021
Harvard University
2007-2017
Hertie Institute for Clinical Brain Research
2008-2014
Abstract Biomolecular condensation constitutes an emerging mechanism for transcriptional regulation. Recent studies suggest that the co-condensation between transcription factors (TFs) and DNA can generate mechanical forces driving genome rearrangements. However, reported generated by protein-DNA are typically below one piconewton (pN), questioning its physiological significance. Moreover, force-generating capacity of these condensates in chromatin context remains unknown. Here, we show...
In light of the potential effects spaceflight on anterior segment eye, there is a pressing need for imaging to be available and accessible monitor astronauts’ ocular health, including alterations cornea lens. We aim highlight clinical basis astronauts. explore impacts spaceflight-associated hazards, microgravity radiation, risk developing pathology trauma, infection, dry eye symptoms, cataracts, possibly additional pathologies from increased radiation exposure. Such risks value that...
New neurons generated in the adult dentate gyrus are constantly integrated into hippocampal circuitry and activated during encoding recall of new memories. Despite identification extracellular signals that regulate survival integration adult-born such as neurotrophins neurotransmitters, nature intracellular modulators required to transduce those remains elusive. Here, we provide evidence expression transcriptional activity nuclear factor T cell c4 (NFATc4) progenitor cells. We show NFATc4...
Transcription is essential for neurite and axon outgrowth during development. Recent work points to the involvement of nuclear factor activated T cells (NFAT) in regulation genes important growth guidance. However, NFAT has not been reported directly control transcription outgrowth-related genes. To identify transcriptional targets, we performed an silico promoter analysis found a putative site within GAP-43 promoter. Using vitro vivo experiments, demonstrated that NFAT-3 regulates GAP-43,...
The cGMP-dependent protein kinase type I (cGKI) has multiple functions including a role in axonal growth and pathfinding of sensory neurons, counteracts Semaphorin 3A (Sema3A)-induced cone collapse. Within the nervous system, however, transcriptional regulation cGKI is still obscure. Recently, transcription factor tumor suppressor p53 been reported to promote neurite outgrowth by regulating gene expression factors that extension, but specific targets genes may counteract collapse have not...
Abstract The regulatory mechanisms responsible for the gene expression pattern associated with axotomy-dependent signaling affecting neuronal phenotype, including axonal regenerative program, remain unclear. To further this understanding, we recently performed DNA methylation temporal profiling in lumbar dorsal root ganglia (DRG) after axotomy of central spinal (non-regenerating) and peripheral sciatic nerve (regenerating) branches. microarrays mouse promoters CpG islands (Roche/NimbleGen)...