Timothy S. Johnson
A5037972391- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Shoulder Injury and Treatment
- Sports injuries and prevention
- Classical Antiquity Studies
- Osteoarthritis Treatment and Mechanisms
- Shoulder and Clavicle Injuries
- Reconstructive Surgery and Microvascular Techniques
- Orthopedic Surgery and Rehabilitation
- Surgical Sutures and Adhesives
- Classical Philosophy and Thought
- Historical, Religious, and Philosophical Studies
- Nerve Injury and Rehabilitation
- Orthopaedic implants and arthroplasty
- Venous Thromboembolism Diagnosis and Management
- Silk-based biomaterials and applications
- Historical and Literary Studies
- Neuroscience and Neuropharmacology Research
- 3D Printing in Biomedical Research
- Mesenchymal stem cell research
- Peripheral Nerve Disorders
- Viral Infectious Diseases and Gene Expression in Insects
- Nasal Surgery and Airway Studies
- Biomedical Ethics and Regulation
- Sports Performance and Training
Penn State Milton S. Hershey Medical Center
2011-2024
Vanderbilt University
2024
University of California, Los Angeles
2024
American Society of Plastic Surgeons
2023
Hershey (United States)
2020-2023
Creative Commons
2023
Pennsylvania State University
2019-2022
Slocum Research and Education Foundation
2019-2022
Brown University
2022
Vanderbilt University Medical Center
2017-2021
Abstract In the current environment of diverse product pipelines, rapidly fluctuating market demands and growing competition from biosimilars, biotechnology companies are increasingly driven to develop innovative solutions for highly flexible cost‐effective manufacturing. To address these challenging demands, integrated continuous processing, comprised high‐density perfusion cell culture a directly coupled capture step, can be used as universal biomanufacturing platform. This study reports...
Background: Most surgeons believe that graft choice for anterior cruciate ligament (ACL) reconstruction is an important factor related to outcome; however, revision may be limited due previously used grafts. Hypotheses: Autograft use would result in increased sports function, activity level, and decreased osteoarthritis symptoms (as measured by validated patient-reported outcome instruments). failure reoperation rate 2 years after ACL reconstruction. Study Design: Cohort study; Level of...
Background: At the time of anterior cruciate ligament (ACL) reconstruction, there are usually concurrent meniscal and articular cartilage injuries. It is unclear if a significant difference between intra-articular injuries at primary ACL reconstruction compared with revision reconstruction. Purpose: To compare found surgery to determine associations specific findings. Study Design: Cohort study (prevalence); Level evidence, 2. Methods: Primary surgeries were identified from Multicenter...
The factors that lead to patients failing multiple anterior cruciate ligament (ACL) reconstructions are not well understood.Multiple-revision ACL reconstruction will have different characteristics than first-time revision in terms of previous and current graft selection, mode failure, chondral/meniscal injuries, surgical charactieristics.Case-control study; Level evidence, 3.A prospective multicenter database was utilized for the time period from March 2006 June 2011. Patients were divided...
Background: Revision anterior cruciate ligament (ACL) reconstruction has been documented to have worse outcomes compared with primary ACL reconstructions. Purpose/Hypothesis: The purpose of this study was determine if the prevalence, location, and/or degree meniscal and chondral damage noted at time revision predicts activity level, sports function, osteoarthritis symptoms 2-year follow-up. hypothesis that loss high-grade will result in lower levels, decreased participation, more pain,...
Background: While revision anterior cruciate ligament reconstruction (ACLR) can be performed to restore knee stability and improve patient activity levels, outcomes after this surgery are reported inferior those primary ACLR. Further reoperations ACLR have an even more profound effect on satisfaction outcomes. However, there is a current lack of information regarding the rate risk factors for subsequent Purpose: To report reoperations, procedures performed, reoperation 2 years Study Design:...
Background: Although graft choice may be limited in the revision setting based on previously used grafts, most surgeons believe that for anterior cruciate ligament (ACL) reconstruction is an important factor related to outcome. Hypothesis: In ACL setting, there would no difference between autograft and allograft rerupture rate patient-reported outcomes (PROs) at 6-year follow-up. Study Design: Cohort study; Level of evidence, 2. Methods: Patients who had surgery were identified prospectively...
Background: Knees undergoing revision anterior cruciate ligament (ACL) reconstruction typically have more intra-articular injuries than do knees primary reconstruction. Hypothesis: Previous partial meniscectomy (PM) is associated with a higher rate of chondral lesions at ACL reconstruction, whereas previous meniscal repair (MR) not compared no surgery. Study design: Cohort study (Prevalence); Level evidence, 2. Methods: Data from multicenter cohort was reviewed to determine the history prior...
Background: The occurrence of physiologic knee hyperextension (HE) in the revision anterior cruciate ligament reconstruction (ACLR) population and its effect on outcomes have yet to be reported. Hypothesis/Purpose: prevalence HE ACLR 2-year outcome were studied with hypothesis that preoperative ≥5° is a risk factor for (ACL) graft rupture. Study Design: Cohort study; Level evidence, 2. Methods: Patients undergoing identified prospectively enrolled between 2006 2011. inclusion criteria...
Previous attempts to engineer human ear-shaped constructs mimicked shape but lacked the flexibility and size of a ear. Recently, authors engineered flexible cartilage by incorporating perichondrium-like layer into construct. In this study, they used lyophilized swine perichondrium as pseudoperichondrium, examined its ability confer tissue-engineered cartilage, it in ear.Auricular chondrocytes were isolated from swine. Chondrocytes mixed with fibrin polymer gelled form 5 x 20-mm constructs....
Abstract Background and Objectives Photochemical tissue bonding (PTB) combines photoactive dyes with visible light to create fluid‐tight seals between surfaces without causing collateral thermal damage. The potential of PTB improve outcomes over standard care microsurgical reanastomoses blood vessels in ex vivo models was evaluated. Study Design mechanical strength integrity suture repairs porcine brachial arteries ( n = 10) were compared using hydrostatic testing leak point pressure (LPP)....
Background: Anterior cruciate ligament (ACL) reconstruction failure occurs in up to 10% of cases. Technical errors are considered the most common cause graft despite absence validated studies. Limited data available regarding agreement among orthopaedic surgeons causes primary ACL and accuracy tunnel placement. Hypothesis: Experienced knee have a high level interobserver reliability about failure, anatomic characteristics, Study Design: Cohort study (diagnosis); Level evidence, 3. Methods:...
Knees undergoing revision anterior cruciate ligament reconstruction (rACLR) have a high prevalence of articular cartilage lesions.The chondrosis at the time rACLR is associated with meniscal status and lower extremity alignment.Cross-sectional study; Level evidence, 3.Data from prospective Multicenter ACL Revision Study (MARS) cohort were reviewed to identify patients preoperative alignment films. Lower was defined by weightbearing line (WBL) as percentage tibial plateau width, while...
In this study, we investigated the effects of alternating tangential flow (ATF) cell separation on high-density perfusion cultures. We have developed methods to estimate theoretical residence times cells in ATF system and discovered that long (above 75 s) correlate with decreased growth, metabolism, productivity. calculated energy dissipation rates transfer line filter empirically studied impacts increased exchange culture, determining hydrodynamic stress can lead size, lactate production,...
Background: Patient-reported outcomes (PROs) are a valid measure of results after revision anterior cruciate ligament (ACL) reconstruction. Revision ACL reconstruction has been documented to have worse when compared with primary Understanding positive and negative predictors PROs will allow surgeons modify potentially improve outcome for patients. Purpose/Hypothesis: The purpose was describe test the hypothesis that patient- technique-specific variables associated these outcomes. Study...
A retrospective review was done on 501 patients who had bilateral sequential one-stage total knee replacements from September 1995 to April 2000 evaluate perioperative (inhospital) morbidity. One thousand two were with the receiving regional anesthesia, 286 women and 215 men an average age of 66 years. The transfusion requirement 2.8 units blood per patient. There no deaths, myocardial infarctions, or cerebrovascular accidents. mean length hospital stay 7.2 days. hundred forty-four...
Articular chondrocytes can synthesize new cartilaginous matrix in vivo that forms functional bonds with native cartilage. Other sources of may have a similar ability to form cartilage healing capacity. This study evaluates the various chondrocyte produce and Disks articular articular, auricular, costal were harvested from swine. Articular, or suspended fibrin glue (experimental), alone (control), placed between disks cartilage, forming trilayer constructs, implanted subcutaneously into nude...
Articular cartilage health is an important issue following anterior cruciate ligament (ACL) injury and primary ACL reconstruction. Factors present at the time of reconstruction may influence subsequent progression articular damage.Larger meniscus resection reconstruction, increased patient age, body mass index (BMI) are associated with odds worsened damage revision reconstruction.Case-control study; Level evidence, 3.Subjects who had data in databases Multicenter Orthopaedics Outcomes...
Background: Revision anterior cruciate ligament (ACL) reconstruction has been documented to have worse outcomes compared with primary ACL reconstruction. Hypothesis: Certain factors under the control of surgeon at time revision surgery can both negatively and positively affect outcomes. Study Design: Case-control study; Level evidence, 3. Methods: Patients undergoing were identified prospectively enrolled between 2006 2011. Data collected included baseline demographics, intraoperative...
There are several techniques that have been described for distal biceps tendon repair but there is still controversy regarding the optimal technique. Our hypothesis single-incision technique will a similar complication rate and functionally equivalent restoration of function compared with two-incision approach. A retrospective review consecutive repairs was performed at one institution over 5-year period. Thirty-six patients met inclusion criteria 26 were available follow-up including...
Background: Meniscal preservation has been demonstrated to contribute long-term knee health. This a successful intervention in patients with isolated tears and associated anterior cruciate ligament (ACL) reconstruction. However, the results of meniscal repair setting revision ACL reconstruction have not documented. Purpose: To examine prevalence 2-year operative success rate repairs setting. Study Design: Case-control study; Level evidence, 3. Methods: All cases concomitant from multicenter...
Background: Meniscal and chondral damage is common in the patient undergoing revision anterior cruciate ligament (ACL) reconstruction. Purpose: To determine if meniscal and/or articular cartilage pathology at time of ACL surgery significantly influences a patient’s outcome 6-year follow-up. Study Design: Cohort study; Level evidence, 3. Methods: Patients reconstruction were prospectively enrolled between 2006 2011. Data collection included baseline demographics, surgical technique,...
Introduction After undergoing breast reconstructive surgery, patients are typically prescribed opioids. Smoking tobacco increases rate of opioid metabolism and is associated with development use disorder (OUD). The aim this study was to determine whether who smoke have an increased risk OUD after surgery. Given that a known factor for injection drug intravenous acquiring blood-borne diseases including human immunodeficiency virus (HIV) hepatitis, the secondary if these also at communicable...