A5058108856- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Sports injuries and prevention
- Shoulder Injury and Treatment
- Osteoarthritis Treatment and Mechanisms
- Tendon Structure and Treatment
- Orthopedic Surgery and Rehabilitation
- Shoulder and Clavicle Injuries
- Adhesion, Friction, and Surface Interactions
- Orthopaedic implants and arthroplasty
- Lower Extremity Biomechanics and Pathologies
- Nerve Injury and Rehabilitation
- Bone Tissue Engineering Materials
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Polymer Surface Interaction Studies
- Mesenchymal stem cell research
- Bone fractures and treatments
- Foot and Ankle Surgery
- Cardiovascular Effects of Exercise
- Cardiovascular Syncope and Autonomic Disorders
- Elbow and Forearm Trauma Treatment
- Silk-based biomaterials and applications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Vascular Procedures and Complications
University of California, Los Angeles
2015-2024
Vanderbilt University
2024
University of Glasgow
2017-2022
Slocum Research and Education Foundation
2019-2022
Brown University
2022
Vanderbilt University Medical Center
2017-2021
Orthopaedic Hospital
2013-2019
University of California, San Francisco
2017
The Ohio State University Wexner Medical Center
2017
University of Edinburgh
2008-2016
Background: Most surgeons believe that graft choice for anterior cruciate ligament (ACL) reconstruction is an important factor related to outcome; however, revision may be limited due previously used grafts. Hypotheses: Autograft use would result in increased sports function, activity level, and decreased osteoarthritis symptoms (as measured by validated patient-reported outcome instruments). failure reoperation rate 2 years after ACL reconstruction. Study Design: Cohort study; Level of...
The gait patterns of eighteen patients who had a single infarct due to obstruction the middle cerebral artery were evaluated within one week after resumed independent walking and before rehabilitation program been initiated. Gait was analyzed with use motion analysis, force-plate recordings, dynamic surface electromyographic studies muscles lower extremities.The extremity on hemiplegic side stronger association clinical severity muscle weakness than degree spasticity, balance control, or...
Most posterior cruciate ligament reconstruction techniques use both tibial and femoral bone tunnels for graft placement. Because of the acute angle must make to gain entrance into tunnel, abnormal stresses are placed on that could lead failure. An alternative technique involves placement plug from anatomically back tibia (inlay), preventing formation an at attachment site. We used six pairs human cadaver knees compare biomechanical properties these two techniques. One knee each pair...
Muscle contraction can subject healing knee ligament grafts to high loads.To directly measure the effects of quadriceps and hamstrings muscle loads on forces in anterior cruciate ligaments posterior ligaments.Controlled laboratory study.Thirteen cadaveric specimens had load cells installed record resultant both under 5 loading conditions. Cruciate force measurements were repeated with a 100-N applied tendon again combined 50-N biceps semimembranosus-semitendinosus load.Applied resulted mean...
Morbidity and mortality from acute coronary artery occlusion may be reduced if local myocardial adenosine concentration is augmented because 1) collateral blood flow during ischemia increases with infusion, 2) granulocytes that accumulate in the microcirculation are, to a large extent, inhibited by generating superoxide anion free radicals, adhering vascular endothelium, damaging endothelial cells culture. Using cultured lymphoblast model system, we found 5-amino-4-imidazole carboxamide...
Allografts are commonly used during sports medicine surgical procedures in the United States, and their frequency of use is increasing. Based on surgeon reports, it estimated that more than 60 000 allografts were knee surgeries by members American Orthopaedic Society for Sports Medicine 2005. In there governmental agencies other regulatory bodies involved oversight tissue banks. 2005, Food Drug Administration finalized its requirements current good practice has mandated new rules regarding...
Background: At the time of anterior cruciate ligament (ACL) reconstruction, there are usually concurrent meniscal and articular cartilage injuries. It is unclear if a significant difference between intra-articular injuries at primary ACL reconstruction compared with revision reconstruction. Purpose: To compare found surgery to determine associations specific findings. Study Design: Cohort study (prevalence); Level evidence, 2. Methods: Primary surgeries were identified from Multicenter...
The factors that lead to patients failing multiple anterior cruciate ligament (ACL) reconstructions are not well understood.Multiple-revision ACL reconstruction will have different characteristics than first-time revision in terms of previous and current graft selection, mode failure, chondral/meniscal injuries, surgical charactieristics.Case-control study; Level evidence, 3.A prospective multicenter database was utilized for the time period from March 2006 June 2011. Patients were divided...
Background: Some surgeons presently reconstruct both the anteromedial and posterolateral bundles of anterior cruciate ligament. The purposes this study were to measure abilities single-bundle anatomic double-bundle reconstructions restore anteroposterior laxities rotational kinematics intact knee levels compare graft forces in reconstructed knees with native ligament for same loading conditions. Methods: Native force tibial rotations recorded during passive extension tests without applied...
Joint injury and osteoarthritis affect millions of people worldwide, but attempts to generate articular cartilage using adult stem/progenitor cells have been unsuccessful. We hypothesized that recapitulation the human developmental chondrogenic program pluripotent stem (PSCs) may represent a superior approach for restoration. Using laser-capture microdissection followed by microarray analysis, we first defined surface phenotype (CD166low/negCD146low/negCD73+CD44lowBMPR1B+) distinguishing...
Arthroscopically guided reconstruction of the anterior cruciate ligament is a common orthopaedic procedure. While many associated complications have been described in literature, postoperative septic arthritis has received little attention. Although rare after reconstruction, can devastating consequences. From group 831 consecutive patients, we report 4 (0.48%) who sustained arthritis. All patients had similar symptoms and were treated by same surgeon manner. underwent immediate arthroscopic...
Background: The optimal method of replacement the posterior cruciate ligament with a bone-patellar tendon-bone graft is not known. purpose this study was to compare mechanical responses cyclic loading tests allograft replacements fixed tibia one two methods: tibial tunnel or inlay technique. Methods: proximal ends sixty-two replacements, thirty-one technique and in cadaver knees, were subjected 2000 cycles tensile force 50 300 N angle pull at 45° plateau. central 10 mm medial lateral halves...
Background: An acute infection after arthroscopic shoulder surgery is a rare but serious complication. Previous studies estimating the incidence of infections have been conducted, majority these had either relatively small study groups or were not specific to surgery. Purpose: To investigate and compare rates by age group, sex, geographic region, procedures. Study Design: Case series; Level evidence, 4. Methods: A retrospective review large insurance company database was performed for all...
A certain percentage of patients undergoing anterior cruciate ligament (ACL) reconstruction will experience graft failure, and there is mounting evidence that an increased posterior tibial slope (PTS) may be a predisposing factor. Theoretically, under tibiofemoral compression force (TFC), reduced PTS would induce less translation (ATT) lower ACL force.Ten-degree closing wedge osteotomy the proximal tibia significantly reduce alter knee kinematics during robotic testing.Controlled laboratory...
Vascular injury secondary to an acute knee dislocation is a known complication. However, there exist wide discrepancies in the reported rate of vascular this setting.Using large private insurance database, we determined frequency dislocations across year diagnosis, age, sex, and US geographic region proportion these injuries requiring surgical repair.The PearlDiver which contains records from 11 million orthopaedic patients, was searched using ICD-9 diagnostic codes for all events 2004 2009....
Medicare insures the largest population of patients at risk for rotator cuff tears in United States.To evaluate trends incidence, concomitant procedures, and complications with open arthroscopic repairs patients.Cohort study; Level evidence, 3.All who had undergone or repair from 2005 through 2011 were identified a claims database. Annual postoperative compared between these 2 groups.In total, 372,109 analyzed. The incidence decreased (from 6.0 to 4.3 per 10,000 patients, P < .001) while...
Knee dislocations are uncommon but devastating orthopaedic injuries. Little is known about their frequency and the types of patients who affected.Using a large national insurance database, we determined (1) incidence knee dislocation in with injuries examined as function (2) year diagnosis, (3) type (open versus closed, direction), (4) patient demographic factors (sex, age).We searched PearlDiver database private records consisting 11 million diagnoses, using diagnosis (ICD-9-CM) codes for...
Treatment of patellofemoral instability has evolved as our understanding the relevant pathoanatomy improved. In light these developments, current practice patterns and management trends have likely changed to reflect advancements; however, this not been evaluated in a formal study.To determine nationwide patient demographics, surgical trends, postoperative complications associated with operative patellar surgery.Descriptive epidemiological study.A large private-payer database (PearlDiver)...