A5018514790- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Hypothalamic control of reproductive hormones
- Growth Hormone and Insulin-like Growth Factors
- Ovarian function and disorders
- Neural dynamics and brain function
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neural Engineering
- Zebrafish Biomedical Research Applications
- Receptor Mechanisms and Signaling
- Reproductive Physiology in Livestock
- Congenital heart defects research
- Microbial bioremediation and biosurfactants
- Axon Guidance and Neuronal Signaling
- Plant responses to elevated CO2
- Economic and Social Development
- Estrogen and related hormone effects
- Public Policy and Governance
- Neurobiology and Insect Physiology Research
- Stress Responses and Cortisol
- Neuropeptides and Animal Physiology
- Neuroscience, Education and Cognitive Function
- Neurotransmitter Receptor Influence on Behavior
- Nerve injury and regeneration
- Biocrusts and Microbial Ecology
Consejo Nacional de Investigaciones Científicas y Técnicas
2001-2024
Bariloche Atomic Centre
2018-2024
Comisión Nacional de Energía Atómica
2022-2024
Centro Científico Tecnológico - San Juan
2022
National University of Comahue
2015-2018
Fundación Instituto Leloir
2009-2014
Experimental Medicine and Biology Institute
2001-2006
University of Buenos Aires
1999
Fundación Ciencias Exactas y Naturales
1999
The adult dentate gyrus generates new granule cells (GCs) that develop over several weeks and integrate into the preexisting network. Although hippocampal neurogenesis has been implicated in learning memory, specific role of GCs remains unclear. We examined whether immature adult-born neurons contribute to information encoding. By combining calcium imaging electrophysiology acute slices, we found weak afferent activity recruits few mature while activating a substantial proportion neurons....
Neurons born in the adult dentate gyrus develop, mature, and connect over a long interval that can last from six to eight weeks. It has been proposed that, during this period, developing neurons play relevant role hippocampal signal processing owing their distinctive electrical properties. However, it remained unknown whether immature be recruited into network before synaptic functional maturity have achieved. To address question, we used retroviral expression of green fluorescent protein...
The adult hippocampus continuously generates new cohorts of immature neurons with increased excitability and plasticity. window for the expression those unique properties in each cohort is determined by time required to acquire a mature neuronal phenotype. Here, we show that local network activity regulates rate maturation adult-born along septotemporal axis hippocampus. Confocal microscopy patch-clamp recordings were combined assess marker expression, morphological development, functional...
The adult dentate gyrus produces new neurons that morphologically and functionally integrate into the hippocampal network. In brain, most excitatory synapses are ensheathed by astrocytic perisynaptic processes regulate synaptic structure function. However, these formed during embryonic or early postnatal development it is unknown whether astrocytes can also ensheathe of born adulthood and, if so, they play a role in their transmission. Here, we used combination serial-section immuno-electron...
Compartmental models are the theoretical tool of choice for understanding single neuron computations. However, many incomplete, built ad hoc and require tuning each novel condition rendering them limited usability. Here, we present T2N, a powerful interface to control NEURON with Matlab TREES toolbox, which supports generating stable over broad range reconstructed synthetic morphologies. We illustrate this novel, highly detailed active model dentate granule cells (GCs) replicating wide...
Polycyclic aromatic hydrocarbons (PAHs) are widespread globally, primarily due to long-term anthropogenic pollution sources. Since PAHs tend accumulate in soil sediments, liverwort plants, such as
Adult neurogenesis could be considered as a homeostatic mechanism that accompanies the continuous growth of teleost fish. As an alternative but not excluding hypothesis, adult would provide form plasticity necessary to adapt brain environmental challenges. The zebrafish pallium is structure involved in processing various cognitive functions and exhibits extended neurogenic niches throughout periventricular zone. involvement neuronal addition learning-related plastic has been explored this...
Rat and hamster brain tissues were used to investigate the possible existence of a follicle stimulating hormone (FSH)-releasing factor with similar characteristics lamprey gonadotropin-releasing III (lGnRH-III) form proposed in previous reports. The present studies involved isolation purification molecule by high-performance liquid chromatography (HPLC), identification radioimmunoassay, sequence analysis automated Edman degradation, mass spectrometry examination biological activity....
Gonadotropin-releasing hormone (GnRH) is a decapeptide widely known for its role in regulating vertebrate reproduction by serving as signal from the hypothalamus to pituitary gonadotropes. The first form of GnRH be identified was isolated mammals (mGnRH) and same has been reported all studied, which includes marsupials placental mammals. Later, another variant, chicken GnRH-II (cGnRH-II) shown expressed together with mGnRH brains jawed vertebrates, including such rats, monkeys humans. Our...
IN previous studies we found that there is a critical period during rat postnatal development when motor training starting at age 30 days (P30) but not before or after this age, induces bilateral lifetime drop in Bmax of the muscarinic radioligand [3H]QNB striatum. We examined possibility striatal NGF level would be determining factor for normal occurrence synaptic plasticity. With aim, rats underwent P30–37 with without simultaneous perfusion into left At P70, expected enduring fall sites...
The participation of type I GnRH receptor (GnRH-R) on GnRH-II-induced gonadotropin secretion in rat pituitary cells was investigated. Furthermore, we extended the study GnRH-II action to ovarian cells. able mobilize inositol triphosphate (IP3) and induce LH FSH release a dose-dependent manner GnRH-I-like manner. GnRH-analog 135-18 (agonist for II GnRH-R antagonist GnRH-R) unable elicit any cellular response tested these responses were blocked by GnRH-R-antagonists CRX or 135-18, suggesting...