A5052818228- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Pancreatic function and diabetes
- Ion channel regulation and function
- Diabetes Treatment and Management
- Diabetes and associated disorders
- Olfactory and Sensory Function Studies
- Neuroscience and Neuropharmacology Research
- Cardiac electrophysiology and arrhythmias
- ATP Synthase and ATPases Research
- Lipid Membrane Structure and Behavior
- Neuroscience and Music Perception
- Protein Kinase Regulation and GTPase Signaling
- Adipose Tissue and Metabolism
- Neurobiology and Insect Physiology Research
- Neuropeptides and Animal Physiology
- Nitric Oxide and Endothelin Effects
- Sleep and Wakefulness Research
- Cardiac Ischemia and Reperfusion
- Receptor Mechanisms and Signaling
- melanin and skin pigmentation
- Diet and metabolism studies
- Physiological and biochemical adaptations
- Neurological Disorders and Treatments
- Neural dynamics and brain function
Hokkaido University
2016
Imperial College London
2009-2011
Saga University
2011
University of Dundee
2005-2008
Ninewells Hospital
2005-2008
Neurosciences Institute
2005
Kyushu University
2002
Kagoshima University
1997
Insulin receptor substrate 2 (Irs2) plays complex roles in energy homeostasis. We generated mice lacking Irs2 β cells and a population of hypothalamic neurons (RIPCreIrs2KO), all (NesCreIrs2KO), proopiomelanocortin (POMCCreIrs2KO) to determine the role CNS cell. RIPCreIrs2KO displayed impaired glucose tolerance reduced cell mass. Overt diabetes did not ensue, because escaping Cre-mediated recombination progressively populated islets. NesCreIrs2KO hyperphagia, obesity, increased body length,...
OBJECTIVE Glucagon-like peptide (GLP)-1 inhibits food intake, acting both in the periphery and within central nervous system. It is unclear if gut-derived GLP-1 can enter brain, or whether from preproglucagon (PPG) cells lower brainstem required to activate receptors. Brainstem PPG neurons, however, have been poorly characterized, due difficulties identifying these while viable. This study provides data on electrical properties of their regulation by orexigenic anorexigenic peptides....
Mechanical stress induces auto/paracrine ATP release from various cell types, but the mechanisms underlying this are not well understood. Here we show that of induced by hypotonic (HTS) in bovine aortic endothelial cells (BAECs) occurs through volume-regulated anion channels (VRAC). Various VRAC inhibitors, such as glibenclamide, verapamil, tamoxifen, and fluoxetine, suppressed HTS-induced ATP, concomitant Ca(2+) oscillations NO production. They did not, however, affect production...
OBJECTIVE Glucagon-like peptide 1 (GLP-1) is involved in the central regulation of food intake. It produced within brain by preproglucagon (PPG) neurons, which are located primarily stem. These neurons project widely throughout brain, including to appetite centers hypothalamus, and believed convey signals related satiety. Previous work demonstrated that they directly activated leptin electrical activity afferent vagus. Another satiety hormone, cholecystokinin (CCK), has also been linked...
The hypothalamic melanocortin system is crucial for the control of appetite and body weight. Two five receptors, MC3R MC4R are involved in energy homeostasis, with having major influence. It generally thought that main impact on circuits external to arcuate nucleus, any effect locally nucleus inhibitory proopiomelanocortin-expressing (POMC) neurons. In contrast, using current- voltage-clamp recordings from identified neurons, we demonstrate agonists depolarize POMC neurons a separate...
We examined the effects of superoxide anion (O) generated by xanthine plus oxidase (X/XO) on intracellular Ca(2+) concentration ([Ca(2+)](i)) and muscle contractility in cultured bovine aortic smooth cells (BASMC). Cells were grown collagen-coated dish for measurement [Ca(2+)](i). Pretreatment with X/XO inhibited ATP-induced transient release-activated entry (CRAC) after thapsigargin-induced store depletion, both which reversed dismutase (SOD). In contrast, transients induced high-K(+)...
Insulin receptor substrate 2 (Irs2) plays complex roles in energy homeostasis. We generated mice lacking Irs2 β cells and a population of hypothalamic neurons (RIPCreIrs2KO), all (NesCreIrs2KO), proopiomelanocortin (POMCCreIrs2KO) to determine the role CNS cell. RIPCreIrs2KO displayed impaired glucose tolerance reduced cell mass. Overt diabetes did not ensue, because escaping Cre-mediated recombination progressively populated islets. NesCreIrs2KO hyperphagia, obesity, increased body length,...
To evaluate relative factors for anorectic effects of l-histidine, we performed behavioral experiments measuring food and fluid intake, conditioned taste aversion (CTA), disturbance, c-Fos immunoreactive (Fos-ir) cells before after i.p. injection with l-histidine in rats. Animals were injected saline (9 ml/kg, i.p.) a control group, containing (0.75, 1.5, 2.0 g/kg) group. Injection decreased the average value statistically significant found animals 1.5 or g/kg but not 0.75 l-histidine. Taste...