A5062936106- Cavitation Phenomena in Pumps
- Hydraulic and Pneumatic Systems
- Material Dynamics and Properties
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cholesterol and Lipid Metabolism
- Plasma Diagnostics and Applications
- Cyclone Separators and Fluid Dynamics
- Fluid Dynamics and Turbulent Flows
- Theoretical and Computational Physics
- Engineering Applied Research
- Rocket and propulsion systems research
- Hydraulic flow and structures
- Lipoproteins and Cardiovascular Health
- Turbomachinery Performance and Optimization
- Peroxisome Proliferator-Activated Receptors
- Gas Dynamics and Kinetic Theory
- Hormonal Regulation and Hypertension
- Semiconductor Lasers and Optical Devices
- Semiconductor materials and devices
- Thermodynamic properties of mixtures
- Water Systems and Optimization
- Blood Pressure and Hypertension Studies
- Heat Transfer Mechanisms
- Fluid Dynamics and Vibration Analysis
- Spacecraft and Cryogenic Technologies
Osaka University
2024
Fujitsu (Japan)
2007-2023
Hyogo Prefectural Amagasaki General Medical Center
2020-2023
Creative Commons
2023
Yokohama National University
2008-2022
Sysmex (Japan)
2021
Central Research Institute of Electric Power Industry
2004-2020
Kobe City Medical Center General Hospital
2020
Shiga University of Medical Science
2014-2019
Dassault Systèmes (France)
2016-2017
Abstract Although there are many known Mendelian genes linked to epileptic or developmental and encephalopathy (EE/DEE), its genetic architecture is not fully explained. Here, we address this incompleteness by analyzing exomes of 743 EE/DEE cases 2366 controls. We observe that damaging ultra-rare variants (dURVs) unique an individual significantly overrepresented in EE/DEE, both the other non-EE/DEE genes. Importantly, enrichment dURVs significant, even subset with diagnostic ( P =...
Shiga toxin is a bacterial consisting of A and B subunits. Generally, the essential cytotoxicity thought to be mediated by subunit, which possesses RNA cleavage activity thus induces protein synthesis inhibition. We previously reported, however, that binding 1-B subunit globotriaosyl ceramide, functional receptor for toxin, intracellular signals in manner dependent on glycolipid-enriched membrane domains, or lipid rafts. Although precise role this signaling mechanism not known, here we...
Physical and electrical influences on plasma etching the inside of a microtrench in SiO2 were numerically investigated using Monte Carlo simulation ions electrons with aid surface charge continuity Poisson’s equation. When aspect ratio is greater than seven, bottom charged up to potential sufficient prevent influence all incident ions, realistic initial energy 300 eV for within period required monolayer stripping, resulting etch stop. The cause stop purely result local charging due...
We report an investigation of the heterogeneity in supercooled liquids and glasses using non-Gaussianity parameter. simulate selenium a binary Lennard-Jones system by molecular dynamics. In three time domains can be distinguished: increase on ps scale due to vibrational (ballistic) motion atoms, followed growth, local relaxations ( beta relaxation) at not too high temperatures, finally slow drop long times. The follows intermediate domain sqrt[t] law. This is explained collective hopping...
In very low specific speed range (ns<0.25), the efficiency of centrifugal pump designed by conventional method becomes remarkably low. Therefore, positive-displacement pumps have been widely used for long. However, remain associated with problems such as noise and vibration they require high manufacturing precision. Since recently are becoming higher in rotational smaller size, there appear to be many expectations develop a new performance range. The purpose this study is investigate...
In order to control and suppress performance curve instability characterized by the positive slope of head-capacity a mixed flow pump, very simple passive method utilizing shallow grooves mounted on casing wall parallel pressure gradient (J-groove) is proposed. The optimum groove dimension location for suppressing such an are determined experimentally. Results show that adequate proper can perfectly without decreasing pump maximum efficiency. remarkable effect decrease both swirl strength...
The plasma levels of free oxysterols (7-ketocholesterol; 7alpha-hydroxy-, 7beta-hydroxy-, 25-hydroxy-, and 27-hydroxycholesterol; 5alpha,6alpha-epoxycholestanol) in patients with diabetes mellitus hypercholesterolemia were determined using gas chromatography-mass spectrometry selective ion monitoring. We studied 39 mellitus, 20 nondiabetic hypercholesterolemia, 37 normal controls. Plasma cholesterol diabetic hypercholesterolemic showed no statistical difference. 7-ketocholesterol was...
ApoA-I and HDL promote cellular cholesterol efflux in the early stages of reverse transport (RCT) pathway. A low plasma HDL-C level is characteristic atherogenic dyslipidemia patients with type 2 diabetes. We evaluated lipid levels expression factors related to RCT diabetic patients, effects an HMG-CoA reductase inhibitor, simvastatin, were studied.Messenger RNA (mRNA) circulating mononuclear cells was analyzed by transcription-polymerase chain reaction (RT-PCR), focusing on following...
Blood based β-amyloid (Aβ) assays that can predict amyloid positivity in the brain are high demand. Current studies utilize immunoprecipitation mass spectrometry assay (IP-MS), which has specificity for measuring analytes, have revealed precise plasma Aβ potential to detect brain. In this study, we developed Aβ40 and Aβ42 immunoassays using a fully automated immunoassay platform is used routine clinical practice. Our showed sensitivity (limit of quantification: 2.46 pg/mL [Aβ40] 0.16 [Aβ42])...
Consideration is given to a wall conductance inside trench in SiO2 exposed by plasma etching order predict the surface charging as function of aspect ratio. With lack conductance, physical and electrical etch stops occur at high ratios due difference velocity distribution between electrons positive ions incident on wafer. The sensitivity ratio bottom potential decreases with increasing electron conductance. pulsed operation simulated simplified manner, predicted be decreased massive negative...
Cushing's syndrome, including its mild form/state of adrenal-dependent subset (subclinical syndrome; subCS), is known to enhance glucose intolerance, hypertension and obesity. Recently, subclinical disease (subCD) has been identified, but prevalence the extent consequent metabolic derangement are unclear. We screened 90 type 2 diabetic patients hospitalized in our department for subCD, according diagnostic guideline proposed by working group Japanese Ministry Health, Welfare Labor 2006....
Large axial thrust is produced on the rotor assembly of high-pressure rocket pumps. Thus, to ensure reliability bearings supporting high rotational speed rotor, precise balancing essential. To realize complete balancing, back shroud main impeller employed as balance piston a self-balancing type system in which moves axially compensate unbalance force. In this system, often applied, complicated internal flow characteristics and pressure distributions are very important for predicting by...
Background: Studies have shown that walking in forests can a relaxation effect, but the participants only walked for about 15 minutes. Methods and findings: The study adopted an open crossover design, which 22 healthy male volunteers were randomly assigned to two groups. first group Kodo forest course urban second, while second completed walks reverse order. was 4 km from foot pass back, took around 2 hours. at exercise intensity equal of course. We used both physiological psychological...
Generalized susceptibility $\ensuremath{\chi}(\mathbf{q},\ensuremath{\omega})$ for binary soft-sphere mixtures is computed the first time a frequency range which includes both $\ensuremath{\alpha}$ and $\ensuremath{\beta}$ peaks in supercooled fluid phase with superlongtime (10 \ifmmode\times\else\texttimes\fi{} ${10}^{6}$ steps) molecular dynamics simulation. This gives us reliable spectral data wide of over 5 orders magnitude at various wave numbers, so that we can discuss without...
In order to control and suppress instabilities caused by swirl flow, the authors have proposed a very simple passive method utilizing shallow grooves mounted on casing wall or diffuser wall(s) parallel pressure gradient. The groove is termed “J-groove.” theoretically analyzed experimentally proved capable of suppressing rotating stall in vaneless diffuser. performance curve instability characterized positive slope head-capacity mixed flow pump for entire range. continuation, this work aimed...
ObjectiveInsulin-like growth factor (IGF)-binding proteins (IGFBPs) are a family of thought to modulate IGF function. By employing an in vitro culture system human hematopoietic stem cells cocultured with murine bone marrow stromal cells, we examined the effects IGF-I and IGFBPs on early B-cell development.Materials MethodsHuman CD34+ were MS-5 for 4 weeks, pro–B-cell number was analyzed by flow cytometry. After administration reagents that supposed or IGFBP function culture, effect...
We studied the effect of insulin on HDL-mediated cholesterol efflux from macrophages. The potential involvement cholesteryl ester hydrolysis and membrane transport was also addressed.Human monocyte-derived THP-1 cells were developed into Cholesterol measured by incubating macrophages, labeled with [³H]-cholesterol, HDL for 24 h. treated (0-500 nM) 30 min prior to addition HDL. To investigate molecular mechanisms insulin, expressions neutral hydrolase (nCEH) ATP-binding cassette transporter...