A5045280383- Acne and Rosacea Treatments and Effects
- Dermatology and Skin Diseases
- Hidradenitis Suppurativa and Treatments
- Retinoids in leukemia and cellular processes
- Wound Healing and Treatments
- Colorectal and Anal Carcinomas
- Skin Protection and Aging
- Pharmacological Effects of Natural Compounds
- Herpesvirus Infections and Treatments
- Oral Health Pathology and Treatment
- Hair Growth and Disorders
- Chemotherapy-related skin toxicity
- Microscopic Colitis
- Dermatologic Treatments and Research
- T-cell and B-cell Immunology
- melanin and skin pigmentation
- Psoriasis: Treatment and Pathogenesis
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Nerve injury and regeneration
- Advancements in Transdermal Drug Delivery
- Antimicrobial Peptides and Activities
- Streptococcal Infections and Treatments
- Immune Response and Inflammation
- Autoimmune and Inflammatory Disorders
Penn State Milton S. Hershey Medical Center
2016-2025
Pennsylvania State University
2015-2024
Johns Hopkins University
2011-2019
Hershey (United States)
2006-2017
Johns Hopkins Medicine
2012-2015
Translational Genomics Research Institute
2014
Cancer Research Foundation
2006-2011
University of Baltimore
2011
National Foundation for Cancer Research
2009
S:t Eriks Ögonsjukhus
1938
Hidradenitis suppurativa (HS) is a debilitating inflammatory skin disease characterized by painful nodules, drainage and scarring in folds. Injectable adalimumab the only drug approved US Food Drug Administration for treatment of HS. Although systemic Janus kinase (JAK) inhibitors show promise, serious side-effects have been reported. There are no highly effective topical treatments HS; furthermore, contribution epidermal keratinocytes to intense inflammation has largely unexplored.We...
13-cis retinoic acid (13-cis RA; also known as isotretinoin) is the most potent agent available for treatment of acne. It that drug induces apoptosis in cells cultured from human sebaceous glands, but its mechanism action has not been determined. In this study, skin biopsies were taken 7 patients with acne prior to and at 1 week RA. TUNEL staining confirmed RA induced glands. Transcriptional profiling patient gland (SEB-1 sebocytes) indicated lipocalin 2 was among genes highly upregulated by...
Given the widespread use of systemic antibiotics for treatment moderate to severe acne, it is important understand associations such antibiotic with changes not only in Cutibacterium acnes (formerly Propionibacterium acnes) but also complete bacterial community skin.To examine composition, diversity, and resilience skin microbiota associated perturbation individuals acne.This longitudinal cohort study conducted at an academic referral center Maryland from February 11 September 23, 2014,...
How developmental programs reactivate in regeneration is a fundamental question biology. We addressed this through the study of Wound Induced Hair follicle Neogenesis (WIHN), an adult organogenesis model where stem cells regenerate de novo hair follicles following deep wounding. The exact mechanism uncertain. Here we show that self-noncoding dsRNA activates anti-viral receptor toll like 3 (TLR3) to induce intrinsic retinoic acid (RA) synthesis pattern predicts new formation after wounding...
Abstract Background The composition of the skin microbiome varies from infancy to adulthood and becomes most stable in adulthood. Adult acne patients harbour an ‘acne microbiome’ dominated by specific strains Cutibacterium acnes. However, precise timing evolution, development microbiome, shift virulent C. acnes strain during puberty is unknown. Objectives We performed a cross‐sectional pilot study paediatric population understand how when transitions whether distinct emerges subjects....
Background The full mechanism of action isotretinoin [13‐cis retinoic acid (13‐cis RA)] in treating acne is unknown. 13‐cis RA induces key genes sebocytes that are involved apoptosis, including Tumor necrosis factor Related Apoptosis Inducing Ligand (TRAIL). Objectives In this study, we investigated the role RA‐induced TRAIL within SEB‐1 sebocytes. Methods Using and recombinant human (rhTRAIL) protein, assessed induction apoptosis sebocytes, normal keratinocytes patient skin biopsies....
Abstract There are no drugs as effective isotretinoin for acne. Deciphering the changes in microbiome induced by pilosebaceous follicle of successfully treated patients can pave way to identify novel therapeutic alternatives. We determined how follicular with and identified which alterations correlate a successful treatment response. Whole genome sequencing was done on casts from facial follicles acne sampled before, during after treatment. Alterations were assessed correlated response at 20...
Isotretinoin (13-cis RA) is the most potent agent in treatment of acne. Insights into its mechanism action can lead to drug discovery alternative compounds with comparable efficacy but improved safety. The goal this study compare temporal changes gene expression skin acne patients after 1 week and 8 weeks isotretinoin. Microarray analysis was performed on biopsies taken from eight prior at Results were compared data obtained seven biopsied one a study. Distinctly different patterns noted. At...
Infection at barrier sites, e.g., skin, activates local immune defenses that limit pathogen spread, while preserving tissue integrity. Phenotypically distinct γδ T cell populations reside in where they shape immunity to cutaneous infection prior onset of an adaptive response by conventional αβ CD4+ (TCD4+) and CD8+ (TCD8+) cells. To examine the mechanisms used cells control virus replication pathology, we examined after with vaccinia (VACV). Resident expanded combined recruited pathology...
Background Acne keloidalis nuchae (AKN) is a chronic scarring folliculitis with fibrotic papules on the occipital scalp. Its treatment limited and unsatisfactory. Objectives To determine whether targeted ultraviolet B (tUVB) phototherapy will (i) improve clinical appearance of AKN (ii) induce extracellular matrix remodelling in affected lesions. Methods Eleven patients were enrolled prospective, randomized, split-scalp comparison study. One randomly selected side scalp was treated tUVB up to...
Topical formulations of tretinoin precursors (retinol and its ester derivatives) are widely available over the counter may offer similar clinical benefits to those for treatment photoaging. However, which many purported molecular effects retinoids most strongly drives improvements in tretinoin-treated skin remains unclear.To evaluate efficacy topical (TTP) vs (RA) treating moderate severe facial photodamage identify potential biomarkers that correlate with efficacy.This randomized,...