A5068243879- Intraocular Surgery and Lenses
- Corneal surgery and disorders
- Retinal and Macular Surgery
- Glaucoma and retinal disorders
- Ophthalmology and Visual Impairment Studies
- Ocular Surface and Contact Lens
- Multiple Myeloma Research and Treatments
- Connexins and lens biology
- Corneal Surgery and Treatments
- Protein Degradation and Inhibitors
- Traumatic Ocular and Foreign Body Injuries
- Orthopedic Surgery and Rehabilitation
- Peptidase Inhibition and Analysis
- Herpesvirus Infections and Treatments
- Retinoids in leukemia and cellular processes
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Ocular Diseases and Behçet’s Syndrome
- Vascular Tumors and Angiosarcomas
- Anorectal Disease Treatments and Outcomes
- Intraoperative Neuromonitoring and Anesthetic Effects
- Monoclonal and Polyclonal Antibodies Research
- Ocular Oncology and Treatments
- Retinal and Optic Conditions
- Chemokine receptors and signaling
University of Utah
2014-2023
Research to Prevent Blindness
2010-2023
American Society of Colon and Rectal Surgeons
2023
American Society of Cataract and Refractive Surgery
2023
Providence College
2021
Eye Institute of Utah
2009-2021
Alcon (United States)
2016-2020
University of California, San Diego
2019
University of Arizona
2018
University of Phoenix
2018
Patients with relapsed or refractory multiple myeloma (RRMM) represent an unmet clinical need. Belantamab mafodotin (belamaf; GSK2857916) is a first-in-class antibody-drug conjugate (ADC; immunoconjugate) that delivers cytotoxic payload, monomethyl auristatin F (MMAF), to cells. In the phase II DREAMM-2 study (NCT03525678), single-agent belamaf (2.5 mg/kg) demonstrated clinically meaningful anti-myeloma activity (overall response rate 32%) in patients heavily pretreated disease....
Abstract Belantamab mafodotin (belamaf) demonstrated deep and durable responses in patients with heavily pretreated relapsed or refractory multiple myeloma (RRMM) DREAMM-2 (NCT03525678). Corneal events, specifically keratopathy (including superficial punctate and/or microcyst-like epithelial changes (MECs), eye examination findings with/without symptoms), were common, consistent reports from other antibody–drug conjugates. Given the novel nature of corneal events RRMM management, guidelines...
To validate a porcine lens model by comparing density and ultrasound (US) with known human standards using the Infiniti Ozil Intelligent Phacoemulsification (torsional), Whitestar Signature Micropulse (longitudinal), Ellips FX (transversal) modalities.Department of Ophthalmology Visual Sciences, John A. Moran Eye Center, University Utah, Salt Lake City, USA.Experimental study.Lens nuclei were formalin soaked in hour-based intervals divided into 2.0 mm cubes. Density was characterized...
PURPOSE: To compare efficiency and chatter of Infiniti Ozil with without Intelligent Phacoemulsification (IP) the Signature Ellips FX. SETTING: John A. Moran Eye Center, University Utah, Salt Lake City, USA. DESIGN: Experimental study. METHODS: Brunescent 2.0 mm human lens cubes were created by an instrument devised for this Cubes tested (10 per test) time particle removal (efficiency) number times bounced off tip (chatter) at 300 Hg 550 Hg, 50% 100% power, amplitudes (amplitude only)....
To evaluate the optimum on time for most efficient removal of lens fragments using micropulsed ultrasound (US).John A. Moran Eye Center Laboratories, University Utah, Salt Lake City, USA.Experimental study.Twenty porcine nuclei were soaked in formalin 2 hours and then divided into 2.0 mm cubes. Using an US machine with a 0.9 bent 30-degree bevel tip, was varied every millisecond (ms) from ms to 10 off kept constant at ms. Efficiency (time removal) chatter (number fragment repulsions tip)...
PURPOSE: To assess capsular bag opacification and sites of initial posterior capsule (PCO) in human cadaver eyes with square-edged 1-piece or 3-piece hydrophobic acrylic intraocular lenses (IOLs). SETTING: John A. Moran Eye Center, University Utah, Salt Lake City, USA. DESIGN: Experimental study. METHODS: Eyes were immersed 10% formalin after enucleation had anterior segment scanning very-high-frequency ultrasound (Artemis). After the sectioned at equator, gross examination was performed...
To evaluate the effect of varying levels power on phacoemulsification efficiency using CENTURION Vision System.Formalin-soaked porcine lenses were divided into 2-mm cubes; 0.9-mm, balanced tips used. Torsional tested from 10% to 100% at intervals. Vacuum was set 550 mmHg, aspiration 50 ml/min, and intraocular pressure mmHg. Efficiency (time lens removal) chatter (number fragment repulsions tip) determined.Increasing torsional up 60% increased efficiency. This linear 30 (R2 = .90; P < 0.05)....
Purpose To optimize phacoemulsification efficiency by varying the intraocular pressure (IOP) using Centurion Vision System, a monitored forced-infusion system. Setting John A. Moran Eye Center Laboratories, University of Utah, Salt Lake City, USA. Design Laboratory investigation. Methods Porcine lenses were soaked in formalin and divided into 2.0 mm cubes; 0.9 balanced tips used. Intraocular levels tested from 30 to 110 Hg at 10 intervals. Vacuum was set 500 Hg, aspiration 35 mL/min,...
1009 Background: SOR, a multikinase inhibitor targeting tumor growth and angiogenesis, is indicated for adv renal hepatocellular cancer. The Trials to Investigate the Efficacy of SOR (TIES) program four double-blind, randomized, placebo (PL)-controlled, phase IIb screening trials assessing SOR+CRx HER2-negative locally or metastatic (met) BC. Two TIES studies (SOLTI-0701, NU07B1) reported activity vs PL+CRx in pts with no prior BEV. As inhibition receptor tyrosine kinase may overcome BEV...
Purpose To evaluate the efficiency of peristaltic-based and venturi-based vacuums. Setting John A. Moran Eye Center Laboratories, University Utah, Salt Lake City, USA. Design Experimental study. Methods Porcine lenses were hardened with formalin cut into 2.0 mm cubes. Time to fragment removal (efficiency) bounces off tip (chatter) measured using a Signature machine ability switch between vacuum. Micropulse longitudinal transversal ultrasound motions tested. Results Venturi-based vacuum had...
We describe 2 cases in which patients with 4-looped single-piece hydrophilic acrylic intraocular lenses (IOLs) exhibited postoperative complications including capsulorhexis phimosis, decentration, tilt, hyperopic shift, and luxation leading to explantation of the IOL-capsular bag complex. The excessive capsule fibrosis led anterior flexing IOL haptics both cases, even presence a capsular tension ring (CTR). Histopathological analyses revealed thick fibrocellular tissue attached inner surface...
Purpose To determine the optimum power settings in micropulsed ultrasound (US). Setting John A. Moran Eye Center Laboratories, University of Utah, Salt Lake City, USA. Design Experimental study. Methods Pig lenses hardened to be comparable dense human cataracts were cut into 2.0 mm cubes and removed using longitudinal US with previously optimized (6 milliseconds on 6 off a 0.9 30-degree beveled bent phaco tip). The aspiration was set at 40 mL/min vacuum level 550 Hg. Twenty lens tested from...
To evaluate radiused and nonradiused phacoemulsification tips to determine which tip is more efficient in removal of lens fragments using 3 ultrasound (US) modalities.John A. Moran Eye Center Laboratories, University Utah, Salt Lake City, USA.Experimental study.Porcine nuclei were formalin-soaked for 2 hours or then divided into 2.0 mm cubes. Thirty-degree, 0.9 beveled used with torsional, transverse, micropulsed US modalities. Bent torsional transversal US, straight US. Efficiency (time...
PURPOSE: To assess the degree of capsular bag opacification in human cadaver eyes with silicone intraocular lenses (IOLs), specifically comparing differences between round-edged IOLs and modern square-edged IOLs. SETTING: John A. Moran Eye Center, University Utah, USA. DESIGN: Experimental study. METHODS: The were immersed 10% formalin on enucleation. They had anterior segment scanning a very-high-frequency ultrasound (Artemis). After sectioned at equator, gross examination was performed...
To compare the outcome of photorefractive keratectomy (PRK) and complications in patients treated with either loteprednol etabonate 0.5% gel or prednisolone acetate 1% suspension fluorometholone (fml) 0.1% suspension.John A Moran Eye Center, University Utah, Salt Lake City, UT, USA.Prospective, randomized, partially masked trial.PRK was performed on 261 eyes 132 participants. Patients were randomized to a postoperative corticosteroid regimen (loteprednol) followed by (prednisolone/fml)....
Purpose To evaluate pulse type technology used to remove lens fragments during phacoemulsification. Setting John A. Moran Eye Center Laboratories, University of Utah, Salt Lake City, USA. Design Experimental study. Methods Lens nuclei soaked in 10 mL 10% neutral buffered formalin for 2 hours were placed balanced salt solution. Lenses cut into mm × cubes; no more than 36 later, cubes randomly selected testing. Two aspiration and vacuum settings assessed at moderate- high-flow (30 mL/min 300...
To compare the relative efficiency and chatter of 30-degree 0.9 mm Kelman tip (standard tip) Ozil Intrepid Balanced (torsional with identical optimum settings.John A. Moran Eye Center Laboratories, University Utah, Salt Lake City, USA.Experimental study.Porcine nuclei were fixed in formalin cut into 2.0 cubes. Lens cubes phacoemulsified standard torsional tips at 60% 100% amplitude 0%, 25%, 50%, 75%, longitudinal power monitored forced infusion. Experiments performed a constant vacuum,...
A bstract Background: The use of dispersive ophthalmic viscosurgical devices (OVDs) has been shown to provide significant protection against air bubble damage the corneal endothelium when compared with cohesive OVDs. We endothelial protective effects a new OVD, Healon‐D, Viscoat. Methods: Healon‐D and Viscoat were used in randomized masked fashion anterior chamber 40 rabbit eyes during procedure where ultrasound at 70% continuous energy was delivered for 2 min. Two millilitres bubbles...