A5102000181- Intraocular Surgery and Lenses
- Corneal surgery and disorders
- Retinal and Macular Surgery
- Glaucoma and retinal disorders
- Ophthalmology and Visual Impairment Studies
- Connexins and lens biology
- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Biomedical Ethics and Regulation
- Cancer Treatment and Pharmacology
- Dermatologic Treatments and Research
- RNA Interference and Gene Delivery
- Retinal Imaging and Analysis
- Pulmonary Hypertension Research and Treatments
- Orthopedic Surgery and Rehabilitation
- Retinal Development and Disorders
- Vascular Anomalies and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Health and Medical Research Impacts
- Traumatic Ocular and Foreign Body Injuries
Creative Commons
2021
Sankara Nethralaya
2021
Aditya Birla (India)
2021
Christie's
2021
University of Miami
2020
University of Utah
2013-2016
Research to Prevent Blindness
2015
American Academy of Ophthalmology
2015
Achievement Rewards for College Scientists Foundation
2015
Wound induced corneal fibrosis can lead to permanent visual impairment. Keratocyte activation and differentiation play a key role in fibrosis, vimentin, major structural type III intermediate filament, is required component of this process. The purpose our study was develop nonviral therapeutic strategy for treating which we targeted the knockdown vimentin.To determine duration plasmid expression keratocytes, injected naked expressing green fluorescent protein (GFP; pCMV-GFP) into an...
Purpose To evaluate the optimum off time for most efficient removal of lens fragments using micropulse ultrasound (US). Setting John A. Moran Eye Center Laboratories, University Utah, Salt Lake City, USA. Design Experimental study. Methods Porcine nuclei were soaked in formalin 2 hours and then cut into 2.0 mm cubes Signature US machine with a bent 0.9 phaco tip 30-degree bevel. The on was 7 milliseconds (ms), varied from to 20 ms steps. Phacoemulsification efficiency (time fragment removal)...
Purpose To evaluate the efficiency of peristaltic-based and venturi-based vacuums. Setting John A. Moran Eye Center Laboratories, University Utah, Salt Lake City, USA. Design Experimental study. Methods Porcine lenses were hardened with formalin cut into 2.0 mm cubes. Time to fragment removal (efficiency) bounces off tip (chatter) measured using a Signature machine ability switch between vacuum. Micropulse longitudinal transversal ultrasound motions tested. Results Venturi-based vacuum had...
Purpose To determine the optimum power settings in micropulsed ultrasound (US). Setting John A. Moran Eye Center Laboratories, University of Utah, Salt Lake City, USA. Design Experimental study. Methods Pig lenses hardened to be comparable dense human cataracts were cut into 2.0 mm cubes and removed using longitudinal US with previously optimized (6 milliseconds on 6 off a 0.9 30-degree beveled bent phaco tip). The aspiration was set at 40 mL/min vacuum level 550 Hg. Twenty lens tested from...
To evaluate radiused and nonradiused phacoemulsification tips to determine which tip is more efficient in removal of lens fragments using 3 ultrasound (US) modalities.John A. Moran Eye Center Laboratories, University Utah, Salt Lake City, USA.Experimental study.Porcine nuclei were formalin-soaked for 2 hours or then divided into 2.0 mm cubes. Thirty-degree, 0.9 beveled used with torsional, transverse, micropulsed US modalities. Bent torsional transversal US, straight US. Efficiency (time...
To evaluate the effect of vacuum and aspiration rates on phacoemulsification efficiency.John A. Moran Eye Center Laboratories, University Utah, Salt Lake City, USA.Experimental study.Formalin-soaked porcine lenses were divided into 2.0 mm cubes, 0.9 30-degree beveled 20-degree bent tips used with micropulse ultrasound (US) (6 milliseconds 6 off) a peristaltic flow system. Vacuum levels tested at 200, 300, 400, 500 Hg, 20, 35, 50 mL/min. Efficiency (time to lens removal) chatter (number...
Purpose To evaluate pulse type technology used to remove lens fragments during phacoemulsification. Setting John A. Moran Eye Center Laboratories, University of Utah, Salt Lake City, USA. Design Experimental study. Methods Lens nuclei soaked in 10 mL 10% neutral buffered formalin for 2 hours were placed balanced salt solution. Lenses cut into mm × cubes; no more than 36 later, cubes randomly selected testing. Two aspiration and vacuum settings assessed at moderate- high-flow (30 mL/min 300...
<b><i>Background:</i></b> We report 2 patients who have undergone radial keratotomy (RK) preceding ReSTOR® multifocal intraocular lens (IOL; Alcon, Fort Worth, Tex., USA) implantation in their nondominant eyes and TECNIS® monofocal IOL (Abbott Medical Optics, Abbott Park, Ill., dominant eyes. <b><i>Methods:</i></b> Retrospective review of underwent hybrid monovision with TECHNIS® IOLs at the time cataract surgery after a remote history RK....
Angiogenesis plays a key role in tumor growth. Vascular endothelial growth factor (VEGF) is pro-angiogenic that involved angiogenesis. When VEGF binds to membrane-bound vascular receptor 2 (mVEGFR2), it promotes Through alternative polyadenylation, VEGFR2 also expressed soluble form (sVEGFR2). sVEGFR2 sequesters and therefore anti-angiogenic. The aim of this study was show treatment with previously developed reported antisense morpholino oligomer shifts expression from mVEGFR2 would lead...
We describe a patient with secondary open-angle glaucoma and serous macular detachment associated pulmonary hypertension.A 59 year-old male hypertension presented vision loss was noted to have bilateral engorged epibulbar vessels, blood in Schlemm's canal, elevated intraocular pressure, retinal venous tortuosity detachments. Enhanced depth optical coherence tomography (ED-OCT) showed detachments marked choroidal thickening. Fluorescein angiography indocyanine green revealed vascular...
We report the case of a 40-year-old female patient treated with implantation Acrysof® IQ ReSTOR® lens (Alcon, Fort Worth, Tex., USA) overlaying Acrysof EXpand® minus piggyback (Alcon).The had high myopia and was diagnosed presbyopia bilateral posterior subcapsular cataract. She desired to be spectacle-free opted undergo placement ReSTOR multifocal lens. The necessary intraocular (IOL) power +3.5 in right eye +4.0 left eye, though range commercially available lenses is +6.0 +34.0 D. In order...
Pachychoroid disease spectrum includes central serous chorioretinopathy (CSR) and pachychoroid neovasculopathy (PNV). phenotype is characterized by choroidal hyperpermeability, dilated vessels (pachyvessels), focal or diffuse increase in thickness. Newer imaging modalities have aided the diagnosis of diseases. Herein, we present a case active concurrent CSR with PNV middle-aged patient successful treatment photodynamic therapy intravitreal anti-vascular endothelial growth factor (VEGF)...