A5065385514- Receptor Mechanisms and Signaling
- Genetic and Kidney Cyst Diseases
- Protist diversity and phylogeny
- Microtubule and mitosis dynamics
- Immune Cell Function and Interaction
- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- Architecture and Computational Design
- Cancer-related Molecular Pathways
- Neuropeptides and Animal Physiology
- PARP inhibition in cancer therapy
- Ubiquitin and proteasome pathways
MRC Protein Phosphorylation and Ubiquitylation Unit
2018
University of Dundee
2018
Sapienza University of Rome
2013-2015
Abstract Muscarinic receptors, expressed in several primary and metastatic tumours, appear to be implicated their growth propagation. In this work we have demonstrated that M2 muscarinic receptors are glioblastoma human specimens cell lines. Moreover, characterized the effects of agonist arecaidine on survival both two different lines (U251 MG U87 ) cultures obtained from biopsies. Cell analysis has strongly decreased proliferation glioma cultures. This effect was dose time dependent. FACS...
Dynein is the sole processive minus-end directed microtubule motor found in animals. It has roles cell division, membrane trafficking, and migration. Together with dynactin, dynein regulates centrosomal orientation to establish maintain polarity, controls focal adhesion turnover anchors microtubules at leading edge. In higher eukaryotes, dynein/dynactin requires additional components such as Bicaudal D form an active complex for regulating its cellular localization. Spindly a protein that...
Abstract Ubiquitylation is a protein modification implicated in several cellular processes. This process reversible by the action of deubiquinating enzymes (DUBs). USP45 ubiquitin specific protease about which little known, aside from roles DNA damage repair and differentiation vertebrate retina. Here, using mass spectrometry we have identified Spindly as new target USP45. Our data show that are part same complex their interaction specifically depends on catalytic activity In addition,...
Abstract Dynein is the sole minus-end directed microtubule motor found in animals. It has roles cell division, membrane trafficking, and migration. Together with dynactin, dynein regulates centrosomal orientation to establish maintain polarity, controls focal adhesion turnover anchors microtubules at leading edge. In higher eukaryotes, dynein/dynactin requires additional components such as Bicaudal D form an active complex for regulating its cellular localization. Spindly a protein that...