A5057954499- Endoplasmic Reticulum Stress and Disease
- Fungal and yeast genetics research
- Protease and Inhibitor Mechanisms
- Photosynthetic Processes and Mechanisms
- RNA Research and Splicing
- Peptidase Inhibition and Analysis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Vitamin C and Antioxidants Research
- Microbial Inactivation Methods
- Autophagy in Disease and Therapy
- Nuclear Receptors and Signaling
- Phytochemistry and Biological Activities
- Gene Regulatory Network Analysis
- Biocrusts and Microbial Ecology
- Heat shock proteins research
- Liver Disease Diagnosis and Treatment
- Diabetes and associated disorders
- Protein Structure and Dynamics
- Alzheimer's disease research and treatments
- Essential Oils and Antimicrobial Activity
- Bacterial Genetics and Biotechnology
- Algal biology and biofuel production
- RNA regulation and disease
- Genetic Neurodegenerative Diseases
- Blood Coagulation and Thrombosis Mechanisms
University of Kashmir
2016-2024
University of Massachusetts Chan Medical School
2023
University of Northern British Columbia
2020
Indian Institute of Science Bangalore
2012-2013
The biotechnological uses of algae and cyanobacteria have been widely discussed in the context climate change consequent efforts to circularize economies, minimize carbon release reuse waste streams. Their great potential bioproduction bioremediation has barely exploited, particularly for well-characterized red Galdieria sulphuraria Cyanidioschyzon merolae. These other Cyanidiales are excellent candidates enhancement metabolic engineering a broad spectrum applications including production...
Abstract Two fission yeast mitotic activators, Cdc13 and Cdc25, have been shown to increase in concentration correlation with cell size, proposed thereby regulate size at division. Here, we show that the expression of both Cdc25 are, fact, dependent, as apposed simply sizecorrelated due time-dependent expression. However, also find their dependence is regulated by different mechanisms. was known be transcriptionally. translationally. Its transcript not a size-dependent manner, rather protein...
IRE1 is a transmembrane signalling protein that activates the unfolded response under endoplasmic reticulum stress. endowed with kinase and endoribonuclease activities. The ribonuclease activity of can switch substrate specificities to carry out atypical splicing Xbp1 mRNA or trigger degradation specific mRNAs. mechanisms regulating distinct activities have yet be fully understood. Here, we report Bcl-2 family Bid as novel recruit complex, which directly interacts cytoplasmic domain IRE1....
The multiple short introns in Schizosaccharomyces pombe genes with degenerate cis sequences and atypically positioned polypyrimidine tracts make an interesting model to investigate canonical alternative roles for conserved splicing factors. Here we report functions interactions of the S. slu7(+) (spslu7(+)) gene product, known from Saccharomyces cerevisiae human vitro reactions assemble into spliceosomes after first catalytic reaction dictate 3' splice site choice during second reaction. By...
Abstract Alpha1-antitrypsin (α1AT) is an abundant serine-protease inhibitor in circulation. It has important role neutralizing the neutrophil elastase activity. Different pathogenic point mutations like Z (E342K) -α1AT have been implicated development of liver cirrhosis and Chronic Obstructive Pulmonary Disease (COPD), latter being a cluster progressive lung diseases including chronic bronchitis emphysema. M3-α1AT (376Glu > Asp) another variant α1AT which so far largely considered as...
Ajuga bracteosa Wall ex. Benth. (Lamiaceae) has been reported to possess many biological activities including antibacterial, antifungal, antispasmodic and antioxidant activity but there is no report as such on its mutagenic and/or anti-mutagenic activity. The aim of the present study was isolate compounds from methanol extract aerial parts determine their against mutagen, EMS in animal model mice. undertaken order corroborate traditional use plant bracteosa. were isolated using silica gel...
IRE1 belongs to a type I transmembrane protein family harboring two functional domains, cytoplasmic domain with kinase and RNAse catalytic activity, the luminal domain, which is involved in sensing of unfolded proteins. molecule undergoes dimerization lumenal functionally activates C-terminal domain. activation directly related transition between monomeric dimeric forms. We have deduced quaternary structures from published crystal structure IRE1. One large stable interface that requires...
Abstract Unfolded protein response is a dynamic signalling pathway, which involved in the maintenance of proteostasis and cellular homeostasis. IRE1, transmembrane represents start point highly conserved UPR cascade. IRE1 endowed with kinase endoribonuclease activities. The activation domain by trans-autophosphorylation leads to its RNAse domain. performs atypical splicing Xbp1 mRNA degradation mRNAs an effector function known as Regulated Dependent Decay (RIDD). regulation distinctive...
Abstract The Unfolded Protein Response (UPR) is a dynamic cellular pathway that helps maintain proteostasis during endoplasmic reticulum (ER) stress. One of the key UPR sensors IRE1, which plays central role in managing ER stress and interacts with other pathways to regulate cell homeostasis. Akt signalling pathway, on hand, crucial survival involved diverse functions like growth, proliferation, glucose metabolism, survival. This study explores interplay between these two important pathways....