A5006176085- HIV/AIDS Research and Interventions
- SARS-CoV-2 detection and testing
- Mobile Health and mHealth Applications
- SARS-CoV-2 and COVID-19 Research
- Streptococcal Infections and Treatments
- HIV Research and Treatment
- Viral gastroenteritis research and epidemiology
- HIV, Drug Use, Sexual Risk
- Syphilis Diagnosis and Treatment
- Reproductive tract infections research
- Graphite, nuclear technology, radiation studies
- Adolescent Sexual and Reproductive Health
- Chemical Safety and Risk Management
- Ethics in Clinical Research
- Antimicrobial Resistance in Staphylococcus
- Global Maternal and Child Health
- Nuclear and radioactivity studies
- Infective Endocarditis Diagnosis and Management
- Cervical Cancer and HPV Research
- Reproductive Health and Contraception
- Viral Infections and Immunology Research
- HIV/AIDS oral health manifestations
- ICT in Developing Communities
- HIV/AIDS drug development and treatment
- Respiratory viral infections research
Roche (United States)
2025
Materials Systems (United States)
2017-2022
Centers for Disease Control and Prevention
2013-2018
Santa Clara Valley Medical Center
2007
To compare the sensitivity and specificity of recommended 2-step rapid antigen detection test (RADT) with confirmatory culture vs point-of-care (POC) polymerase chain reaction (PCR) Roche cobas® Liat® Strep A for group Streptococcus (GAS) in pediatric patients pharyngitis, to investigate impact these tests on antibiotic use a large clinic. This prospective, open-label study was conducted at single site during fall/winter 2016–2017. total 275 aged 3 18 years symptoms pharyngitis had...
Cervical cancer is a preventable and highly curable disease when detected early adequately treated, yet it remains the leading cause of cancer-related death in women Kenya due to low screening coverage treatment. Implementing World Health Organization guidelines for human papillomavirus (HPV) challenging complex logistics result return follow-up requiring multiple clinic visits. Increasing use mobile technology can support care cervical programs. We developed prospective clinico-economic...
Objectives: This study examines the impact of an intervention to promote dual-method contraceptive use among HIV concordant and discordant couples already using condoms for prevention. Methods: A three-armed randomized, controlled trial was conducted at a voluntary testing counseling clinic in Lusaka, Zambia; 251 were randomized. Control received family planning education referral outside nonbarrier contraceptives, 1 offer contraceptives research clinic, 2 plus presentation designed reduce...
South Africa has the largest HIV treatment program worldwide. Retention in care and medication adherence remain problematic necessitating innovative solutions for improving care. The increasing availability use of mobile technology can support positive clinical outcomes persons living with HIV. iThemba Life is a health app designed input from African professionals patients, promoting engagement through access to medical results.This study aimed test feasibility acceptability receiving viral...
Human immunodeficiency virus types 1 and 2 (HIV-1 HIV-2) diagnostic testing algorithms recommended by the Centers for Disease Control involve up to three tests rely mostly on detection of viral antigen host antibody responses. HIV-1 p24 antigen/HIV-1/HIV-2 antibody-reactive specimens are confirmed with an immunochromatographic HIV-1/HIV-2 differentiation assay, negative or indeterminate results from assay resolved HIV-1-specific nucleic acid amplification test (NAT). The performance a...
Abstract Background The global burden of sexually transmitted infections (STIs) is high and there have been reports increasing chlamydial gonorrheal infections. High-volume screening programs for Chlamydia trachomatis (CT) Neisseria gonorrhoeae (NG) are an important component STI control. This study evaluated the high-volume workflow performance cobas® CT/NG assay use on automated Roche 6800 system, with cobas p 480 instrument pre-analytics, compared Aptima Combo 2 Hologic Panther system....
ABSTRACT Background SARS-CoV-2 causes COVID-19, which can be fatal and is responsible for a global pandemic. Variants with increased transmissibility or the potential to evade immunity have emerged represent threat pandemic control. of concern (VOC) identified by sequencing viral RNA, more rapid methods detection subsets signature mutations. Methods We developed multiplex, real-time RT-PCR assay (cobas ® Variant Set 1) qualitative differentiation three key mutations in spike protein: del...
Diagnostic testing is essential for management of the COVID-19 pandemic. An agile assay design methodology, optimized cobas® 6800/8800 system, was used to develop a dual-target, qualitative SARS-CoV-2 RT-PCR test using commercially available reagents and existing sample processing thermocycling profiles. The limit detection 30-52 copies/mL USA-WA1/2020. Assay sensitivity confirmed variants Alpha, Beta, Gamma, Delta Kappa. coefficients variation cycle threshold number (Ct) were between 1.1...
Background: Mother to child transmission (MTCT) of HIV constitutes a major source new pediatric infections in Cameroon. Objective: The aim this implementation research was assess outcomes and effectiveness providing life-long antiretroviral therapy (ART) for HIV-positive pregnant breastfeeding women (Option B+). Methods: From October 2013 July 2014, women, not on (ARV) prophylaxis ART, were recruited from 22 purposefully selected health facilities the Northwest Southwest regions prospective,...
Abstract Diagnostic testing is essential for management of the COVID-19 pandemic. An agile assay design methodology, optimized cobas ® 6800/8800 system, was used to develop a dual-target, qualitative SARS-CoV-2 RT-PCR test using commercially available reagents and existing sample processing thermocycling profiles. The limit detection 0.004 0.007 TCID 50 /mL USA-WA1/2020. Assay sensitivity confirmed variants Alpha, Beta, Gamma, Delta Kappa. coefficients variation cycle threshold number (Ct)...
Rapid antigen detection tests (RADT) and bacterial culture are the current standard of care for diagnosing Group A Strep in pediatric patients. Polymerase Chain Reaction (PCR) offer improved turn-around-times at point-of-care (POC) or laboratory. PCR has demonstrated sensitivity over reference previous studies. The performance QuickVue test group was evaluated during fall winter seasons 2016/17 a primary clinic. Concordant results from cobas® Liat® (a POC assay (POC PCR)), Solana GAS Assay...
<sec> <title>BACKGROUND</title> South Africa has the largest HIV treatment program worldwide. Retention in care and medication adherence remain problematic necessitating innovative solutions for improving care. The increasing availability use of mobile technology can support positive clinical outcomes persons living with HIV. iThemba Life is a health app designed input from African professionals patients, promoting engagement through access to medical results. </sec> <title>OBJECTIVE</title>...