A5031643280- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Computational Drug Discovery Methods
- Bioinformatics and Genomic Networks
- Plant-Microbe Interactions and Immunity
- RNA modifications and cancer
- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- Extracellular vesicles in disease
- Circular RNAs in diseases
- Banana Cultivation and Research
- Plant Virus Research Studies
- 3D Printing in Biomedical Research
- Andrographolide Research and Applications
- Cholinesterase and Neurodegenerative Diseases
- Protein Tyrosine Phosphatases
- Molecular Biology Techniques and Applications
- Rheumatoid Arthritis Research and Therapies
- Artificial Intelligence in Healthcare
- Biochemical and Structural Characterization
- Transgenic Plants and Applications
- Fungal Biology and Applications
- Hemoglobinopathies and Related Disorders
- RNA regulation and disease
- Genomics and Phylogenetic Studies
Cleveland State University
2022-2024
Bharath University
2024
Tamil Nadu Agricultural University
2014-2018
Bharathiar University
2015-2018
Abstract The correlation between messenger RNA (mRNA) and protein abundances has long been debated. sequencing (RNA-seq), a high-throughput, commonly used method for analyzing transcriptional dynamics, leaves questions about whether we can translate RNA-seq-identified gene signatures directly to changes. In this study, utilized set of 17 widely assessed immune wound healing mediators in the context canine volumetric muscle loss investigate mRNA abundances. Our data reveal an overall...
Abstract Although mesenchymal stromal cell (MSC) based therapies hold promise in regenerative medicine, their clinical application remains challenging due to issues such as immunocompatibility. MSC-derived exosomes are a promising off-the-shelf therapy for promoting wound healing cell-free manner. However, the potential customize content of MSC-exosomes, and understanding how modifications influence exosome effects on tissue regeneration remain underexplored. In this study, we used an vitro...
MicroRNAs are the key regulators of gene expression and their abnormal in immune system may be associated with several human diseases such as inflammation, cancer autoimmune diseases. Elucidation miRNA disease association through interactome will deepen understanding its mechanisms. A specialized database for miRNAs is highly desirable to demonstrate associations interactome.miRNAs specific related were retrieved from curated databases HMDD, miR2disease PubMed literature based on MeSH...
Skeletal muscle has a robust, inherent ability to regenerate in response injury from acute chronic. In severe trauma, however, complete regeneration is not possible, resulting permanent loss of skeletal tissue referred as volumetric (VML). There are few consistently reliable therapeutic or surgical options address VML. A major limitation investigation possible therapies the absence well-characterized large animal model. this study, we present results comprehensive transcriptomic, proteomic,...
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that affects the synovial joints. Nearly 1.6 billion patients are affected by RA worldwide and incidence of about 0.5 to 1%. Recent studies reveal immune cell responses secretion factors important for control RA.In this study, a set 402 phytochemicals with anti-inflammatory properties 16 target proteins related diseases were identified from literature they subjected network analysis. The protein-protein interaction (PPI) was...
Tobacco mosaic virus (TMV) infects several crops of economic importance (e.g., tomato) and remains as one the major concerns to farmers. TMV enters host cell produces capping enzyme RNA polymerase. The viral genome replicates further produce multiple mRNAs which encodes proteins, including coat protein an RNA-dependent polymerase (RdRp), well movement protein. replicase domain was chosen for virtual screening studies against small molecules derived from ligand databases such PubChem...
Multiple sclerosis (MS), a chronic autoimmune disorder, affects the central nervous system of many young adults. More than half MS patients develop cognition problems. Although several genomic and transcriptomic studies are currently reported in cognitive impairment, comprehensive repository dealing with all experimental data is still underdeveloped. In this study, we combined text mining, gene regulation, pathway analysis, genome-wide association (GWAS) to identify miRNA biomarkers explore...
Alzheimer’s disease (AD), a multifactorial neurodegenerative disorder, is prevalent among the elderly population. It complex trait with mutations in multiple genes. Although US Food and Drug Administration (FDA) has approved few drugs for AD treatment, definitive cure remains elusive. Research efforts persist seeking improved treatment options AD. Here, hybrid pipeline proposed to apply text mining identify comorbid diseases an omics approach common genes between five diseases—dementia, type...
microRNA (miRNA)–messenger RNA (mRNA or gene) interactions are pivotal in various biological processes, including the regulation of gene expression, cellular differentiation, proliferation, apoptosis, and development, as well maintenance homeostasis pathogenesis numerous diseases, such cancer, cardiovascular neurological disorders, metabolic conditions. Understanding mechanisms miRNA–mRNA can provide insights into disease potential therapeutic targets. However, extracting these efficiently...
A BSTRACT Ovarian cancer presents significant challenges in clinical oncology due to its high prevalence, heterogeneity, and late-stage diagnosis. Our study explores the application of single-cell RNA sequencing (scRNA-Seq) bulk enhance our understanding ovarian at molecular level. We highlight diagnostic strategies emphasize critical role scRNA-Seq unraveling intricate cellular composition phenotypic plasticity within tumors. also discuss identification rare cell subtypes, characterization...
Abstract In the mouse distal terminal phalanx (P3), it remains unclear why amputation at less than 33% of digit results in regeneration, while exceeding 67% leads to non-regeneration. Unraveling molecular mechanisms underlying this disparity could provide crucial insights for regenerative medicine. study, we aim investigate tissues within wound bed understand tissue microenvironment associated with versus non-regenerative outcomes. We employed a P3-specific model mice, integrated time-series...
MicroRNAs (miRNAs) are short non-coding RNAs known to be involved in the gene regulatory functions human. Major histocompatibility complex (MHC) located on arm of chromosome 6 remains as one most important regions associated with several human diseases. The spans ~4 Mb and covers >120 expressed genes. Gene expression at transcriptional post level is modulated by microRNA (miRNA) collision sequence polymorphism epigenetic factors. In this study, we aim predict miRNA responsible for different...
Although mesenchymal stromal cell (MSC) based therapies hold promise in regenerative medicine, their applications clinical settings remain challenging due to issues such as immunocompatibility and stability. MSC-derived exosomes, small vesicles carrying various bioactive molecules, are a promising cell-free therapy promote tissue regeneration. However, it remains unknown mainly regarding the ability customize content of how alterations MSC microenvironment influence exosome content, effects...
Banana bunchy top virus (BBTV), the pathogen causing banana disease (BBTD) belongs to genus Babuvirus of family Nanoviridae and produces significant yield loss. BBTD is most destructive viral diseases affecting bananas worldwide infections that result in bunched leaves, stunted fruitless plants. So far, there are no effective control measures for controlling preventing this disease. The amino terminal region movement protein responsible cell-to-cell movement. present study aims at inhibiting...
Banana bunchy top virus (BBTV), the pathogen causing banana disease (BBTD) belongs to genus Babuvirus of family Nanoviridae and produces significant yield loss. BBTD is most destructive viral diseases affecting bananas worldwide infections that result in bunched leaves, stunted fruitless plants. So far, there are no effective control measures for controlling preventing this disease. The amino terminal region movement protein responsible cell-to-cell movement. present study aims at inhibiting...