A5017278215- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Polyomavirus and related diseases
- Cancer, Hypoxia, and Metabolism
- Full-Duplex Wireless Communications
- Cancer Immunotherapy and Biomarkers
- Antenna Design and Analysis
- Immune cells in cancer
- Tryptophan and brain disorders
- Cancer Research and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Economic and Financial Impacts of Cancer
- Renal cell carcinoma treatment
- Immunotherapy and Immune Responses
- COVID-19 Pandemic Impacts
- Trauma and Emergency Care Studies
- Neuroscience of respiration and sleep
- BRCA gene mutations in cancer
- Catalytic Processes in Materials Science
- Health Systems, Economic Evaluations, Quality of Life
- Facial Rejuvenation and Surgery Techniques
- COVID-19 and Mental Health
- Wound Healing and Treatments
- Global Cancer Incidence and Screening
- Obstructive Sleep Apnea Research
Miami VA Healthcare System
2022-2025
University of Washington
2023-2025
Brigham and Women's Hospital
2023-2024
University of Miami
2023-2024
Dana-Farber Cancer Institute
2023-2024
Icahn School of Medicine at Mount Sinai
2024
University of Pennsylvania
2014-2024
University of Tennessee Health Science Center
2024
Mount Sinai Hospital
2024
Carnegie Mellon University
2021-2024
Importance In clinical trials, preoperative immune checkpoint inhibitors (ICIs) have shown activity in advanced cutaneous squamous cell carcinoma (cSCC). However, these studies excluded patients with relevant comorbidities. Objective To evaluate radiologic and pathologic response rates to neoadjuvant-intent programed death protein 1 (PD-1) ICIs a population. Design, Setting, Participants This cohort study of who were treated neoadjuvant cemiplimab or pembrolizumab for cSCC from January 2018...
Abstract Background The impact of non-small cell lung cancer (NSCLC) metabolism on the immune microenvironment is not well understood within platinum resistance. We have identified crucial metabolic differences between cisplatin-resistant (CR) and cisplatin-sensitive (CS) NSCLC cells with elevated indoleamine 2,3-dioxygenase-1 (IDO1) activity in CR, recognized by increased kynurenine (KYN) production. Methods Co-culture, syngeneic, humanize mice models were utilized. C57BL/6 inoculated...
Abstract Background Remaking Recess (RR) is a school-based evidence-based peer social engagement intervention for autistic students. RR involves direct training and coaching with educators; however, educators face several barriers to implementation at both the individual- organizational-levels. This protocol paper describes multi-site study that will test whether an educator-level strategy, , or without school-level teams maximize educators’ use (fidelity sustainment) of students their peers...
Abstract Lung cancer is the leading cause of cancer-related deaths, which adenocarcinoma most common subtype. Despite this, lung and its metastasis are poorly understood, due to difficulties in feasibly recapitulating disease progression predicting clinical benefits therapy. We outline a methodology develop immunogenic orthotopic mouse models, by injecting cell-specific cre viruses into genetically engineered mouse, mirrors defined International Association for Study Cancer. Evaluation...
Mouse models of cyclical intermittent hypoxia (CIH) are used to study the consequences both and oxidative stress in obstructive sleep apnea (OSA). Whether or not a mouse model CIH that simulates OSA patients' oxygenation characteristics would translate into improved patient care remains unanswered. First we identified using desaturation resaturation time 47 subjects from Molecular Signatures Obstructive Sleep Apnea Cohort (MSOSA). We observe cycle is sinusoidal; specifically, increases an...
Background: As research involving human participants increasingly occurs with the aid of digital tools (e.g., mobile apps, wearable and remote pervasive sensors), consent content delivery process is changing. Informed documents to participate in are lengthy difficult for prospective read understand. communication will need include concepts procedures unique health research, making that information accessible meaningful participant critical be informed. This paper describes a methodology...
Merkel cell carcinoma (MCC) is associated with high rates of recurrence and distant metastatic progression. Current guidelines for surveillance imaging are not evidence based. Better characterization the pattern spread will better inform facilitate earlier detection metastases.
Merkel cell carcinoma (MCC) is an aggressive skin cancer with a 40% recurrence rate, lacking effective prognostic biomarkers and surveillance methods. This prospective, multicenter, observational study aimed to evaluate circulating tumor DNA (ctDNA) as biomarker for detecting MCC recurrence.
Dual stain cytology, or "diagnostic cytology", offers a significant increase in sensitivity compared to with slight decrease specificity. This can reduce additional investigations like colposcopies, biopsies, and follow-up visits. Cervical cancer screening for women between 25 65 years of age diagnostic cytology is estimated the incidence cervical by 36% annual mortalities 40%. The reduced number visits mortality will improve quality life. In this article, model was created evaluate...
Older individuals who smoke are at increased risk of having severe outcomes from COVID-19, due to their long-term smoking and underlying health conditions. In this qualitative study, we explored the impact COVID-19 on attitudes toward motivation quit. Participants (N = 30) were enrolled in a larger ongoing randomized controlled cessation trial conducted lung cancer screening setting. From March May 2020, assessed quantitative responses participants' overall concern about changes amount...
Von Hippel-Lindau disease (VHL) is a hereditary disorder associated with malignant tumors including clear cell renal carcinoma (ccRCC). Partial nephrectomy complicated by multilocular tumor occurrence and high recurrence rate. The aim of this study was to evaluate the potential stereotactic body radiotherapy (SBRT) as an alternative treatment approach in VHL patients multiple ccRCC. Patients diagnosis ccRCC were enrolled. SBRT conducted using five fractions 10 Gy or eight 7.5 Gy. primary...
The effect of pharmacy students as primary members on inpatient interdisciplinary mental health teams was investigated.This retrospective study used Veterans Affairs data from veterans who were admitted to an unit January 1, 2010, through December 31, 2012. Eligible had have been hospitalized for at least five days and treated with scheduled medications during the hospitalization. Information collected by investigators included patient age, psychiatric diagnoses, accuracy medication...
Recent studies have shown an association between obstructive sleep apnea (OSA) and cognitive impairment. This study was done to investigate whether varied levels of cyclical intermittent hypoxia (CIH) differentially affect the microvasculature in hippocampus, operating as a mechanistic link OSA We exposed C57BL/6 mice sham [continuous air, arterial O2 saturation (SaO2) 97%], severe CIH inspired fraction (FiO2) = 0.10 (CIH10; SaO2 nadir 61%), or very FiO2 0.05 (CIH5; 37%) for 12 h/day 2 wk....
Von Hippel-Lindau (VHL) disease is a multi-systemic hereditary associated with several benign and malignant tumor entities, including clear cell renal carcinoma (ccRCC). Since ccRCCs grow slowly, nephron sparing surgery typically performed at diameter of 3-4 cm before the metastasizes. However, in case recurrent disease, repeated surgical intervention can impair function. Therefore, it crucial to optimize timing for interventions through better understanding growth kinetics VHL. We...
Background Epidemiological data suggests that obstructive sleep apnea (OSA) is associated with increased cancer incidence and mortality. We investigate the effects of cyclical intermittent hypoxia (CIH), akin to underlying pathophysiology OSA, on lung progression metastatic profile in a mouse model. Methods Intrathoracic injection Ad5CMVCre virus into genetically engineered (GEM) KrasG12D+/-; p53fl/fl; myristolated-p110αfl/fl-ROSA-gfp was utilized induce solitary cancer. Male mice were then...
An aspiration of a dental crown during extraction requires appropriate and timely diagnosis management. While foreign body in procedures is relatively uncommon, it constitutes true medical emergency associated with significant morbidity mortality. We report case mortality from discuss the epidemiology, risk factors, signs symptoms, management, prevention ingestion events.
Introduction Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine malignancy of the skin with predilection for metastases. This study investigates clinical outcomes in patients presenting de novo Stage IV MCC according to metastatic site(s) at presentation. Materials methods Patients who presented one or more sites distant initial diagnosis between 2009 2023 were identified. The presence absence metastases each organ was categorized patient time diagnosis. Overall survival...
202 Background: ASCO guidelines recommend early palliative care (PC) for patients with advanced cancer, defined as referral within 8 weeks of diagnosis. Early has been associated improved quality life, survival and a reduction in healthcare utilization at the end life. We sought to determine role sociodemographic clinical patient factors on timing an embedded supportive oncology (SO) practice impact utilization. Methods: Patients ≥18 years cancer who first received SO visit between...