A5025040615- COVID-19 Clinical Research Studies
- bioluminescence and chemiluminescence research
- Long-Term Effects of COVID-19
- Zebrafish Biomedical Research Applications
- Virus-based gene therapy research
- SARS-CoV-2 and COVID-19 Research
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Pluripotent Stem Cells Research
- Cancer Cells and Metastasis
- COVID-19 and healthcare impacts
- Biotin and Related Studies
- Advanced Glycation End Products research
- Cancer Genomics and Diagnostics
- Aldose Reductase and Taurine
- Diabetes and associated disorders
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Metabolism, Diabetes, and Cancer
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
- Respiratory Support and Mechanisms
- Photoreceptor and optogenetics research
- Cancer Immunotherapy and Biomarkers
- Natural Antidiabetic Agents Studies
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2024
Istituti Fisioterapici Ospitalieri
2024
Sapienza University of Rome
2018-2020
Abstract Diabetes is an established risk factor for pancreatic cancer (PaC), together with obesity, a Western diet, and tobacco smoking. The common mechanistic link might be the accumulation of advanced glycation end‐products (AGEs), which characterizes all above disease conditions unhealthy habits. Surprisingly, however, role AGEs in PaC has not been examined yet, despite evidence tumour‐promoting receptor (RAGE), AGEs. Here, we tested hypothesis that promote through RAGE activation. To...
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer. Most patients present with advanced disease at diagnosis, which only permits palliative chemotherapeutic treatments. RNA dysregulation hallmark of most human cancers, including PDAC. To test the impact processing on PDAC pathology, we performed bioinformatics analysis to identify RNA-binding proteins (RBPs) associated prognosis. Among 12 RBPs progression-free survival, focused MEX3A because it was recently shown mark an...
Abstract Background Low T3 syndrome is frequent in patients admitted to intensive care units for critical illness and pneumonia. It has been reported also with COVID-19, Hodgkin disease chronic lymphocytic leukemia. We analyzed the clinical relevance of COVID-19 and, particular, those associated hematological malignancies. Methods Sixty-two consecutive patients, hospitalized during first wave SARS-CoV-2 outbreak Sant’Andrea University Hospital Rome, were subdivided 38 (Group A), showing low...
Abstract Background Type 1 and 2 diabetes confer an increased risk of pancreatic cancer (PaC) similar magnitude, suggesting a common mechanism. The recent finding that PaC incidence increases linearly with increasing fasting glucose levels supports central role for hyperglycaemia, which is known to cause carbonyl stress advanced glycation end-product (AGE) accumulation through glycolytic activity non-enzymatic reactions. This study investigated the impact hyperglycaemia on invasive tumour...
Clinical outcomes of COVID-19 patients are worsened by the presence co-morbidities, especially cancer leading to elevated mortality rates. SARS-CoV-2 infection is known alter immune system homeostasis. Whether developing present alterations functions which might contribute worse have so far been poorly investigated. We conducted a multi-omic analysis immunological parameters in peripheral blood mononuclear cells (PBMCs) with and without cancer. Healthy donors SARS-CoV-2-negative were also...
Abstract We developed a novel reporter transgenic zebrafish model called MITO-Luc/GFP in which GFP and luciferase expression are under the control of master regulator proliferation NF-Y. In it is possible to visualize cell vivo by fluorescence bioluminescence. this animal model, occur early living embryos, becoming tissue specific juvenile adult zebrafish. By vitro ex experiments we demonstrate that activity animals occurs intestine, kidney gonads, where detectable proliferating cells...
Background Few data are available about the durability of response, induction neutralizing antibodies, and cellular response upon third dose anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine in hemato-oncological patients. Objective To investigate antibody to BNT162b2 patients with hematological malignancy. Methods We measured SARS-CoV-2 anti-spike anti- Omicron T-cell responses 1 month after 93 fragile malignancy (FHM), 51 not oncological subjects (FNO) aged 80–92,...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)