A5010960629- Photoacoustic and Ultrasonic Imaging
- Optical Imaging and Spectroscopy Techniques
- Optical Coherence Tomography Applications
- Thermography and Photoacoustic Techniques
- Nanoplatforms for cancer theranostics
- Thermoregulation and physiological responses
- Advanced Adaptive Filtering Techniques
- Speech and Audio Processing
- Spectroscopy Techniques in Biomedical and Chemical Research
- Air Quality Monitoring and Forecasting
- Image and Signal Denoising Methods
- Orthopedic Infections and Treatments
- Digital Filter Design and Implementation
- Video Coding and Compression Technologies
- Dark Matter and Cosmic Phenomena
- Astrophysics and Cosmic Phenomena
- Advanced Image Processing Techniques
- Contact Dermatitis and Allergies
- Advanced Data Compression Techniques
- Bone fractures and treatments
- Engineering Applied Research
- Structural Health Monitoring Techniques
- Total Knee Arthroplasty Outcomes
- Knee injuries and reconstruction techniques
- Advanced Vision and Imaging
Fudan University
2024
Technical University of Munich
2015-2024
Helmholtz Zentrum München
2015-2024
Institute of Biological and Medical Imaging
2019-2024
Campbell Collaboration
2023
Institute of Bioinformatics and Systems Biology
2016
Tianjin University
2012
Beijing Institute of Technology
2010-2012
Non-invasive glucose monitoring (NIGM) represents an attractive alternative to finger pricking for blood assessment and management of diabetes. Nevertheless, current NIGM techniques do not measure concentrations in but rely on indirect bulk measurement interstitial fluid, where is diluted dynamics are different from those the blood, which impairs accuracy. Here we introduce a new biosensor, termed depth-gated mid-infrared optoacoustic sensor (DIROS), allows, first time, non-invasive...
We present the first catalog of very-high energy and ultra-high gamma-ray sources detected by Large High Altitude Air Shower Observatory (LHAASO). The was compiled using 508 days data collected Water Cherenkov Detector Array (WCDA) from March 2021 to September 2022 933 recorded Kilometer Squared (KM2A) January 2020 2022. This represents main result most sensitive large coverage survey sky above 1 TeV, covering declination $-$20$^{\circ}$ 80$^{\circ}$. In total, contains 90 with an extended...
Being the largest and most accessible organ of human body, skin could offer a window to diabetes-related complications on microvasculature. However, microvasculature is typically assessed by histological analysis, which not suited for applications large populations or longitudinal studies. We introduce ultra-wideband raster-scan optoacoustic mesoscopy (RSOM) precise, non-invasive assessment changes in dermal micro-anatomy, resolved with unprecedented sensitivity detail without need contrast...
Ultra-wideband raster-scan optoacoustic mesoscopy (RSOM) is a novel modality that has demonstrated unprecedented ability to visualize epidermal and dermal structures in-vivo. However, an automatic quantitative analysis of three-dimensional RSOM datasets remains unexplored. In this work we present our framework: Deep Learning Analysis Pipeline (DeepRAP), analyze quantify morphological skin features recorded by extract imaging biomarkers for disease characterization. DeepRAP uses multi-network...
Abstract Melanoma is associated with angiogenesis and vascular changes that may extend through the entire skin depth. Three-dimensional imaging of characteristics in lesions could therefore allow diagnostic insights not available by conventional visual inspection. Raster-scan optoacoustic mesoscopy (RSOM) images microvasculature depth resolutions tens micrometers; however, current RSOM implementations are too slow to overcome strong breathing motions on upper torso where melanoma commonly...
Skin microangiopathy has been associated with diabetes. Here we show that skin-microangiopathy phenotypes in humans can be correlated diabetes stage via morphophysiological cutaneous features extracted from raster-scan optoacoustic mesoscopy (RSOM) images of skin on the leg. We obtained 199 RSOM 115 participants (40 healthy and 75 diabetes), used machine learning to segment layers microvasculature identify clinically explainable pertaining different depths scales detail provided highest...
Surface Review and LettersAccepted Papers No AccessEffects of polymer coating on the structure core-shell particles mechanical performance compressed bulk materialsZhiming Jin, Hailong He, Yajun Zhang, Guang Cheng, Haoze ChenZhiming He Search for more papers by this author , Zhang Cheng Chen https://doi.org/10.1142/S0218625X25400311Cited by:0 (Source: Crossref) PreviousNext AboutFiguresReferencesRelatedDetailsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsRecommend Library...
Abstract Detection and monitoring of esophageal cancer severity require an imaging technique sensitive enough to detect early pathological changes in the esophagus capable analyzing over 360 °in a non‐invasive manner. Optoacoustic endoscopy (COE) has been shown resolve superficial vascular structure lumen rats rabbits using catheter‐type probes. Although these systems can work well small animals, they are unsuitable for larger lumens with thicker walls as required human screening, due their...
Optical endoscopy is the most commonly applied procedure for inspecting gastrointestinal (GI) tract, and it based on different approaches designs, from using a flexible optical scope to swallowing small camera capsule that obtains photographs as advances through digestive tract. Despite its wide use in GI diagnostics theranostics, visualization only allows superficial inspection of wall lining (mucosa), therefore limiting ability obtain information deeper layers. In quest developing methods...
We propose the implementation of hybrid optical and acoustic resolution optoacoustic endoscopy. Laser light is transmitted to tissue by two types illumination for achieving imaging. A 20 MHz ultrasound detector used recording signals. The endoscopy probe attains a 3.6 mm diameter fully encapsulated into catheter system. validate imaging performance endoscope on phantoms ex vivo, discuss necessity extended depth range achieved.
High fidelity optoacoustic (photoacoustic) tomography requires dense spatial sampling of signals using point acoustic detectors. However, in practice, resolution the images is often limited by either due to coarse multi-element arrays or time raster scan measurements. Herein, we investigate a method that integrates information from multiple acquired at sub-diffraction steps into one high image means an iterative registration algorithm. Experimental validations performed target phantoms and...
Raster-scan optoacoustic mesoscopy (RSOM) offers high-resolution non-invasive insights into skin pathophysiology, which holds promise for disease diagnosis and monitoring in dermatology other fields. However, RSOM is quite vulnerable to vertical motion of the skin, can depend on part body being imaged. Motion correction algorithms have already been proposed, but they are not fully automated, anatomical segmentation pre-processing steps that might be performed successfully, site- specific....
The optoacoustic (photoacoustic) technique has been shown to resolve anatomical, functional, and molecular features at depths that go beyond the reach of epi-illumination optical microscopy, offering new opportunities for endoscopic imaging. In this Letter, we investigate merits endoscopy implemented by translating a sound detector in linear or curved geometries. detection geometries are achieved employing an intravascular ultrasound transducer within plastic guide shaped line curve. This...
Abstract Background Differentiation between irritant and allergic skin reactions in epicutaneous patch testing is based largely on subjective clinical criteria, with the risk of high intraobserver interobserver variability. Novel dermatological imaging using optoacoustic mesoscopy allows quantitative three‐dimensional assessment microvascular biomarkers. Objectives We investigated potential to improve precision test evaluation. Methods Sixty‐nine 48 healthy sections 52 patients suspected...
Microcirculatory dysfunction has been observed in the dermal white adipose tissue (dWAT) and subcutaneous (scWAT) of obese humans proposed as an early prediction marker for cardio-metabolic disease progression. In-vivo visualization longitudinal monitoring microvascular remodeling these tissues remains challenging. We compare performance two optoacoustic imaging methods, i.e. multi-spectral tomography (MSOT) raster-scanning mesoscopy (RSOM) visualizing lipid hemoglobin contrast scWAT dWAT a...
Optoacoustic (photoacoustic) endoscopy has shown potential to reveal complementary contrast optical methods, indicating clinical relevance. However operational parameters for accurate optoacoustic must be specified optimal performance. Recent support from the EU Horizon 2020 program ESOTRAC develop a next-generation esophageal endoscope directs interrogation of frequency required implementation. We simulated response esophagus wall and then validated simulation results with experimental...
Abstract Diabetes mellitus affects the microvasculature of several organs, including eyes, heart, brain, kidneys and skin. The skin is most accessible organ could offer a window for detecting diabetes-related systemic effects on microvasculature. However, assessment typically performed based invasive histological analysis, which method that not well suited disease monitoring application to large populations. We introduce ultra-wide band raster-scan optoacoustic mesoscopy (RSOM) precise,...
Sparse recovery algorithms have shown great potential to accurately reconstruct images using limited-view optoacoustic (photoacoustic) tomography data sets, but these are computationally expensive. In this paper, we propose an improvement of the fast converging Split Augmented Lagrangian Shrinkage Algorithm method based on least square QR inversion for improving reconstruction speed. We further show image fidelity when a coherence factor weight result. Phantom and in vivo measurements that...
In this paper, a novel super resolution (SR) framework is proposed to protect flat regions and edges of the reconstructed high (HR) image simultaneously. order remove outliers constrain smoothness HR image, Lorentzian stochastic estimation used for measuring difference between estimated each low (LR) image. Moreover, paper proposes new regularization item, termed as gradient constraint, which incorporates with bilateral total variation (BTV) enhance keep The combination two items superior...
Abstract Microcirculatory dysfunction in dermal (dWAT) and subcutaneous white adipose tissue (scWAT) of obese humans may predict cardio-metabolic disease progression. In-vivo visualization monitoring microvascular remodeling these tissues remains challenging. We compared performance multi-spectral optoacoustic tomography (MSOT) raster-scanning mesoscopy (RSOM) visualizing lipid hemoglobin contrast scWAT dWAT diet-induced (DIO) mice undergoing voluntary wheel running. MSOT quantitatively...
Optoacoustic (photoacoustic) mesoscopy bridges the gap between optoacoustic microscopy and macroscopy enables high-resolution visualization deeper than optical microscopy. Nevertheless, as images may be affected by motion noise, it is critical to develop methodologies that offer standardization quality control ensure high-quality datasets are reproducibly obtained from patient scans. Such development particularly important for ensuring reliability in applying machine learning methods or...
Abstract Microvascular endothelial dysfunction (ED) precedes the ED in larger arteries and is an early marker of cardiovascular disease (CVD). While precise assessment microvascular could thus be used for detection risk stratification CVD, detailed interrogation skin limited by technology available. Herein, we applied a novel approach non-invasive developing fast plane raster-scan optoacoustic mesoscopy (FP-RSOM) to visualize quantify microvasculature perfusion changes during post-occlusive...
This paper proposed a post-filter in frequency domain for enhancing the perceptual quality of coded transient audio. The is used to filter coefficients and consists short-term which derived from Linear Predictive Coding (LPC) predictor based on Discrete Cosine Transform (DCT) frame. In order compensate overall spectral tilt, tilt compensation following post-filter. As result, shapes temporal noise time while introducing little distortion kind doesn't need side information encoder can be any...