A5089609434- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Botulinum Toxin and Related Neurological Disorders
- Neurological diseases and metabolism
- Selenium in Biological Systems
- Aluminum toxicity and tolerance in plants and animals
- Amyotrophic Lateral Sclerosis Research
- Tea Polyphenols and Effects
- Nerve injury and regeneration
- Neurological disorders and treatments
- Nanoparticles: synthesis and applications
- Free Radicals and Antioxidants
- Chinese history and philosophy
- Heat shock proteins research
- Fungal Infections and Studies
- Histone Deacetylase Inhibitors Research
- Endoplasmic Reticulum Stress and Disease
- Nail Diseases and Treatments
- Transition Metal Oxide Nanomaterials
- Multiferroics and related materials
- Signaling Pathways in Disease
- Medicinal Plant Research
- Dielectric properties of ceramics
- Diverse Scientific Research Studies
Rutgers, The State University of New Jersey
2018-2024
AbbVie (United States)
2024
Chongqing University of Science and Technology
2023
Peking University
2021-2022
Peking University Third Hospital
2021-2022
Yangzhou University
2021-2022
Deyang Stomatological Hospital
2021
Rutgers Sexual and Reproductive Health and Rights
2019-2020
Significance Cell-to-cell spreading of αS fibrils leads to amyloid seeding endogenous monomer. Detailed atomic-level mechanistic understanding the fibril process is essential for design therapeutic approaches against Parkinson’s disease. In light its complexity, this remains ill defined at molecular level. Using relaxation-based solution NMR experiments, we mapped a common N-terminal binding interface Ac-αS intrinsically disordered monomer with and off-pathway oligomers elucidate critical...
Parkinson's Disease is characterized by the loss of dopaminergic neurons in substantia nigra pars compacta, extracellular accumulation toxic α-synuclein (αSYN) aggregates, and neuroinflammation. Microglia, resident macrophages brain, are one critical cell types involved Upon sensing stimuli or experiencing oxidative stress, microglia become activated, which further exacerbates In addition, as first line defense central nervous system, play a role αSYN clearance degradation. While...
Silver niobate (AgNbO3) has been widely studied as a new photocatalyst for the degradation of organic pollutants. However, fast recombination photoinduced carriers in AgNbO3 material and its wider band gap are main factors that restrict improvement photocatalytic performance. Herein, construction heterojunction polarization engineering effective strategies were used to modulate migration separation carriers. CuBi2O4/AgNbO3 Z-scheme was successfully designed fabricated, outstanding...
Abstract Alpha-synuclein (αS) fibrils are toxic to cells and contribute the pathogenesis progression of Parkinson’s disease other synucleinopathies. β-Synuclein (βS), which co-localizes with αS, has been shown provide a neuroprotective effect, but molecular mechanism by this occurs remains elusive. Here we show that αS formed in presence βS less cytotoxic, exhibit reduced cell seeding capacity more resistant fibril shedding compared alone. Using solid-state NMR, found overall structure core...
Introduction: Alterations in the visual pathway involving retina have been reported amyotrophic lateral sclerosis (ALS) but they lack consistency and subgroup analysis. We aimed to assess retinal nerve fiber layer (RNFL) ganglion cells (RGCs) alterations different stages of ALS patients their association with progression parameters. Methods: The study population consisted 70 clinically diagnosed 55 age, sex matched controls. All them underwent ophthalmic assessments optical coherence...
Abstract The misfolding, aggregation, and the seeded spread of alpha synuclein (α-Syn) aggregates are linked to pathogenesis various neurodegenerative diseases, including Parkinson’s disease (PD). Understanding mechanisms by which chaperone proteins prevent production seeding α-Syn is crucial for developing effective therapeutic leads tackling diseases. We show that a catalytically inactive variant HtrA1 (HtrA1*) effectively inhibits both monomer aggregation templated fibril seeding,...
Glycation of α-synuclein (αSyn), as occurs with aging, has been linked to the progression Parkinson’s disease (PD) through promotion advanced glycation end-products and formation toxic oligomers that cannot be properly cleared from neurons. DJ-1, an antioxidative protein plays a critical role in PD pathology, proposed repair proteins, yet mechanism not elucidated. In this study, we integrate solution nuclear magnetic resonance (NMR) spectroscopy liquid atomic force microscopy (AFM)...
In current nanoscience bioengineered magnetic nanoparticles (NPs) have come into prominence with considerable impact. These advanced functional materials find outstanding applications in chemical science catalysis, environmental issues, sensing etc, as well biology drug delivery agent, therapeutics and others. We been prompted to architect synthesize a novel Au NP adorned over chitosan-biguanidine polyplex modified core–shell type nanocomposite (Fe3O4/CS-biguanidine/Au NPs). The bioshells...
Abstract The limitation to enhancing photocatalytic performance in photocatalysts lies the rapid recombination of photo‐induced electrons and holes. Herein, AgNbO 3 were synthesized by hydrothermal method. effects temperature on microstructure photocatalytic/piezo‐photocatalytic performances have been systematically investigated. cubes at 180 °C for 24 h exhibited best among all samples. corona poling as an important method polarization engineering is applied promote further separation...
Abstract Alpha-synuclein (αS) fibrils are toxic to cells and contribute the pathogenesis progression of Parkinson’s disease other synucleinopathies. β-Synuclein (βS), which co-localizes with αS, has been shown provide a neuroprotective effect, but molecular mechanism by this occurs remains elusive. Here we show that αS formed in presence βS less cytotoxic, exhibit reduced cell seeding capacity more resistant fibril shedding compared alone. Using solid-state NMR, found overall structure core...
Abstract Amyloid fibril formation of α-synuclein (αS) is associated with multiple neurodegenerative diseases, including Parkinson’s Disease (PD). Growing evidence suggests that progression PD linked to cell-to-cell propagation αS fibrils, which leads seeding endogenous intrinsically disordered monomer via templated elongation and secondary nucleation. A molecular understanding the mechanism driving interactions crucial inhibit amyloid formation. Here, using relaxation-based solution NMR...