A5087515674- Pesticide Exposure and Toxicity
- Diet and metabolism studies
- Skin Protection and Aging
- Air Quality and Health Impacts
- Liver Disease Diagnosis and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Occupational and environmental lung diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Caveolin-1 and cellular processes
- Exercise and Physiological Responses
- Retinoids in leukemia and cellular processes
- Bee Products Chemical Analysis
- Gut microbiota and health
- Synthesis and Characterization of Heterocyclic Compounds
- Cannabis and Cannabinoid Research
- Insect and Pesticide Research
- Inhalation and Respiratory Drug Delivery
- Redox biology and oxidative stress
- Genomics, phytochemicals, and oxidative stress
- Drug Transport and Resistance Mechanisms
- Gastrointestinal motility and disorders
- Antioxidant Activity and Oxidative Stress
- Sphingolipid Metabolism and Signaling
- Peroxisome Proliferator-Activated Receptors
- Ocular Surface and Contact Lens
Rutgers, The State University of New Jersey
2014-2024
Rutgers Sexual and Reproductive Health and Rights
2020
New York Medical College
2020
The Ohio State University
1982-1992
Thomas Jefferson University
1992
UConn Health
1990
Background The gut microbiota is now known to play an important role contributing inflammatory-based chronic diseases. This study examined intestinal integrity/inflammation and the microbial communities in sedentary exercising mice presented with a normal or high-fat diet. Methods Thirty-six, 6-week old C57BL/6NTac male were fed diet for 12-weeks randomly assigned exercise groups. After 12 weeks animals sacrificed duodenum/ileum tissues fixed immunohistochemistry occludin, E-cadherin,...
Significance Lipid-rich plaques in major blood vessels recruit macrophages that further exacerbate the lipid burden and risk of heart attacks or stroke. A local approach to prevent plaque growth has yet be successfully deployed. In this study, we examine how synthetic ligands counteract macrophage atherogenesis de-escalate burden. Using a library sugar-based amphiphilic core-shell layered nanoparticles, demonstrate design principles necessary oxidized uptake suppress scavenger receptor...
Kojic acid (KA) is a naturally occurring fungal metabolite that utilized as skin-lightener and antibrowning agent owing to its potent tyrosinase inhibition activity. While efficacious, KA's inclination undergo pH-mediated, thermal-, photodegradation reduces efficacy, necessitating stabilizing vehicles. To minimize degradation, poly(carbonate-esters) polyesters comprised of KA natural diacids were prepared via solution polymerization methods. In vitro hydrolytic degradation analyses revealed...
Parkinson's Disease is characterized by the loss of dopaminergic neurons in substantia nigra pars compacta, extracellular accumulation toxic α-synuclein (αSYN) aggregates, and neuroinflammation. Microglia, resident macrophages brain, are one critical cell types involved Upon sensing stimuli or experiencing oxidative stress, microglia become activated, which further exacerbates In addition, as first line defense central nervous system, play a role αSYN clearance degradation. While...
Abstract Bile acids (BAs) are signaling molecules synthesized in the liver initially by CYP7A1 and CYP27A1 classical alternative pathways, respectively. BAs essential for cholesterol clearance, intestinal absorption of lipids, endogenous modulators farnesoid x receptor (FXR). FXR is critical maintaining BA homeostasis gut-liver crosstalk. Complex reactions vivo lack suitable animal models impede our understanding functions individual BAs. In this study, we characterized effects three-day...
Intestinal-fatty acid binding protein (IFABP; FABP2) is a 15-kDa intracellular abundantly present in the cytosol of small intestinal (SI) enterocyte. High-fat (HF) feeding IFABP
The ectopic deposition of fat in liver and muscle during obesity is well established, however surprisingly little known about the intestine. We used ob/ob mouse C57BL6/J mice fed a high (HF) diet to examine effects HF feeding, respectively, on intestinal mucosal triacylglycerol (TG) accumulation. Male (wild-type, WT) were low (LF; 10% kcal as fat) or (45%) diets, LF diet, for 3 weeks. In this time frame, WT-HF did not become obese, enabling independent examination obesity. Analysis lipid...
SummaryRadioactive mannitol has been administered to rats with the following results: 1. When given orally, about 50% of carbon is recovered in expired CO2 12 hours. 2. With intraperitoneal injection, largely urine only 2-3% CO2. 3. By injection directly into portal system by way spleen, oxidation comparable or greater than that obtained oral administration obtained. It concluded from these results can be oxidized body if it a route makes first available liver, as feedings.
Lecithin:retinol acyltransferase and retinol-binding protein enable vitamin A (VA) storage transport, respectively, maintaining tissue homeostasis of retinoids (VA derivatives). The precarious VA status the lecithin:retinol acyltransferase–deficient (Lrat−/−) protein–deficient (Rbp−/−) mice rapidly deteriorates upon dietary restriction, leading to signs severe deficiency (VAD). As impact gut morphology functions, VAD is often linked intestinal pathological conditions microbial dysbiosis....
Abstract Detailed analyses of the phospholipid compositions cultured human endothelial cells are reported here. No significant differences were found between from artery, saphenous and umbilical vein. However, due to small sample sizes, relatively large standard deviations for some classes observed. A representative composition is: phosphatidylcholine 36.6%, choline plasmalogen 3.7%, phosphatidylethanolamine 10.2%, ethanolamine 7.6%, sphingomyelin 10.8%, phosphatidylserine 7.1%,...
Atherosclerotic development is exacerbated by two coupled pathophysiological phenomena in plaque-resident cells: modified lipid trafficking and inflammation. To address this therapeutic challenge, we designed investigated the efficacy vitro ex vivo of a novel 'composite' nanotherapeutic formulation with dual activity, wherein nanoparticle core comprises antioxidant α-tocopherol shell based on sugar-derived amphiphilic polymers that exhibit scavenger receptor binding counteract atherogenesis....
Previously-designed amphiphilic scorpion-like macromolecule (AScM) nanoparticles (NPs) showed elevated potency to counteract oxidized low-density lipoprotein (oxLDL) uptake in atherosclerotic macrophages, but failed ameliorate oxLDL-induced inflammation. We designed a new class of composite AScMs incorporating lithocholic acid (LCA), natural agonist for the TGR5 receptor that is known inflammation, with two complementary goals: simultaneously decrease lipid and inhibit pro-inflammatory...