A5008089441- Liver Disease Diagnosis and Treatment
- Fibroblast Growth Factor Research
- Liver physiology and pathology
- Genetic and Kidney Cyst Diseases
- Epigenetics and DNA Methylation
- Alcohol Consumption and Health Effects
- Bariatric Surgery and Outcomes
- Drug Transport and Resistance Mechanisms
- Gallbladder and Bile Duct Disorders
- Diverse Aspects of Tourism Research
- Pediatric Hepatobiliary Diseases and Treatments
- Cruise Tourism Development and Management
- Liver Disease and Transplantation
- Congenital Anomalies and Fetal Surgery
- Appendicitis Diagnosis and Management
- Vector-borne infectious diseases
- Bartonella species infections research
- Maritime Ports and Logistics
- Soft tissue tumor case studies
- Urinary and Genital Oncology Studies
- Gastroesophageal reflux and treatments
- Abdominal Trauma and Injuries
- Tumors and Oncological Cases
- Kruppel-like factors research
- Esophageal and GI Pathology
Johnson University
2013-2024
Rutgers, The State University of New Jersey
2017-2024
Robert Wood Johnson University Hospital
2019
Farnesoid X receptor (FXR) induces fibroblast growth factor 15 (FGF15; human ortholog FGF19) in the gut to potently inhibit bile acid (BA) synthesis liver. FXR activation hepatic stellate cells (HSCs) reduces liver fibrosis (LF). Fgf15 –/– mice develop attenuated LF, but underlying mechanisms for this protection are unclear. We hypothesized that FGF15/19 functions as a profibrotic mediator or mitogen HSCs and increased BAs leads enhanced HSCs, subsequently reducing fibrogenesis. In study,...
The role of intestine‐derived factors in promoting liver regeneration after partial hepatectomy (PHx) are not entirely known, but bile acids (BAs) and fibroblast growth factor 15 (Fgf15) that is highly expressed the mouse ileum could promote hepatocyte proliferation. Fgf15 strongly suppresses synthesis BAs, emerging evidence indicates important for regeneration. mechanisms by which promotes unclear, may do so indirectly reducing BA levels and/or directly cell However, it remains undetermined...
Vertical sleeve gastrectomy (SGx) is a type of bariatric surgery to treat morbid obesity and metabolic dysfunction-associated steatotic liver disease (MASLD). The molecular mechanisms SGx improve MASLD are unclear, but increased bile acids (BAs) FGF19 (mouse FGF15) were observed. FGF15/19 expressed in the ileum response BAs critical not only suppressing BA synthesis also promoting energy expenditure. We hypothesized reduction resolution by may be mediated FGF15/19.
Splenic rupture due to colonoscopy is a rarely reported event in the emergency medicine literature. Patients experiencing such an occurrence are likely report department. This paper documents 84-year-old female who presented department with abdominal pain and nausea less than 24 hours following colonoscopy. An ultrasound revealed splenomegaly free fluid. computed tomography was significant for splenic laceration. She underwent radiologic guided embolization recovered without incident....
Abdominal lipoblastomas are uncommon soft tissue tumors in children and rarely arise from the mesentery. Due to intraabdominal location slow growth, these masses can go unnoticed for long periods of time often found on surgical exploration. We present a case 12-year-old male with years abdominal distension accompanied by new onset early satiety that was have an intra-abdominal mass. He underwent exploratory laparotomy revealing large 33 x 27 15 cm rubbery mesenteric mass displacing entire...
Abstract The hepatitis B core antigen (HBcAg) is an important target for antiviral response in chronic (CHB) patients. However, the correlation between HBcAg hepatocyte nucleus and nucleos(t)ide analogue (NA) therapeutic unclear. We sought to evaluate role of by analysing liver biopsies viral NA‐naïve e (HBeAg) positive (+) CHB patients via immunohistochemistry (IHC). A total 48 HBcAg‐negative (−) with matching baseline characteristics were retrospectively analysed up 288 weeks. Virological...