Cristian Sava

ORCID: 0000-0001-6456-5770
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About
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Research Areas
  • Injury Epidemiology and Prevention
  • Gastric Cancer Management and Outcomes
  • Hepatitis B Virus Studies
  • Cytomegalovirus and herpesvirus research
  • Blood Pressure and Hypertension Studies
  • Lymphoma Diagnosis and Treatment
  • Neuroblastoma Research and Treatments
  • Metastasis and carcinoma case studies
  • Diabetes Treatment and Management
  • Tuberculosis Research and Epidemiology
  • Helicobacter pylori-related gastroenterology studies
  • Gastrointestinal Tumor Research and Treatment
  • Testicular diseases and treatments
  • Ovarian cancer diagnosis and treatment
  • Chronic Kidney Disease and Diabetes
  • Gastrointestinal motility and disorders
  • Sarcoma Diagnosis and Treatment
  • Cancer Treatment and Pharmacology
  • HIV/AIDS drug development and treatment
  • Breast Cancer Treatment Studies
  • Autopsy Techniques and Outcomes
  • Mycobacterium research and diagnosis
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Hedgehog Signaling Pathway Studies
  • Advanced Breast Cancer Therapies

University of Oradea
2001-2025

Clinical Emergency Hospital Bucharest
2023-2025

Universitatea Națională de Știință și Tehnologie Politehnica București
2024

Sapienza University of Rome
2010-2011

Chang Gung Memorial Hospital
2010

Ca' Foncello Hospital
1999-2005

Fondazione IRCCS Istituto Nazionale dei Tumori
1995

Postmenopausal osteoporosis is the most common form of and one major public health problems in developed countries. The prevalence this condition, associated with physiological stage menopause, continuously increasing. This study evaluated effectiveness soy isoflavones as compared to hormone replacement therapy (HRT) low doses, on prevention postmenopausal osteoporosis, by determining bone mineral density (BMD) urinary deoxypyridinoline (D-pyr) women. was conducted over a period 12 months,...

10.3390/jcm7100297 article EN Journal of Clinical Medicine 2018-09-21

Background: This study investigated the association between periodontal disease and acute coronary syndrome (ACS), while examining periodontitis as an independent predictor of STEMI. Materials Methods: included 166 patients with ACS, whom 103 had a history disease. Results: The results showed that were more likely to have tobacco use (78.6%), diabetes (53.1%), poor oral hygiene (72.8%). also found significant severity ACS (STEMI-44.7%, three-vessel/LM disease-30.1%), experiencing frequent...

10.3390/jcm14072447 article EN Journal of Clinical Medicine 2025-04-03

Phenylketonuria (PKU) is caused by mutations in the phenylalanine hydroxylase (PAH) gene and characterized altered amino acid metabolism. More than 1500 known PAH variants intricately determine a spectrum of metabolic phenotypes. We aim to report on clinical presentation identified 23 hyperphenylalaninemia (HPA)/PKU Romanian patients. Our cohort exhibited classic PKU (73.9%, 17/23), mild (17.4%, 4/23), HPA (8.7%, 2/23). Severe central nervous system sequelae are frequent our late-diagnosis...

10.3390/diagnostics13081483 article EN cc-by Diagnostics 2023-04-20

Tuberculosis (TB) is a multisystemic contagious disease produced by Mycobacterium tuberculosis complex bacteria (MTBC), with prevalence of 65:100,000 inhabitants in Romania (six times higher than the European average). The diagnosis usually relies on detection MTBC culture. Although this sensitive method and remains “gold standard”, results are obtained after several weeks. Nucleic acid amplification tests (NAATs), being quick method, represent progress TB. aim study to assess assumption...

10.3390/genes14061231 article EN Genes 2023-06-07

Toxoplasmosis is a zoonotic disease caused by the Toxoplasma gondii protozoan parasite. The aim of this study was to determine frequency acute toxoplasmosis or its presence in medical history 240 pregnant women, depending on age and geographical background. second purpose analyze several aspects (clinical paraclinical) women with toxoplasmosis. identified serological changes including positive toxoplasma IgM, IgG, IgA antibodies. chemiluminescence immunoassay (CLIA) method used detect T....

10.3892/etm.2021.11046 article EN Experimental and Therapeutic Medicine 2021-12-07

<h3>Abstract</h3> Background/Aim: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for generating a global pandemic with deadly consequences and life changes worldwide. With the appearance of new variants virus, clinical manifestations have been reported in pediatric population, some evolution. aim this study was to identify laboratory parameters necessary establish an effective therapy. Patients Methods: In period from August 2020 September 2021, 234...

10.21873/invivo.13019 article EN In Vivo 2022-01-01

Cutaneous melanoma is the most severe skin neoplasia with an increased incidence in recent decades, particularly due to intense exposure sunlight. Our study analyzed characteristics of malignant and role sentinel node biopsy diagnosis prognosis patients cutaneous by identifying regional metastasis. The small or large clusters circulating cancer cells are expressing epitops identified some chemical reaction. These reagents usually monoclonal antibodies high sensitivity specificity which...

10.37358/rc.18.12.6817 article EN cc-by Revista de Chimie 2019-01-15

We investigated the immunohistochemical expression of E-cadherin (product CDH1 gene) and its correlation with clinical-pathological parameters survival rate in molecular groups breast cancer. Our study included female cancer patients diagnosed at Municipal Emergency Clinical Hospital Timisoara followed up five years since diagnosis using formalin fixed paraffin embedded tissue. The traditional prognostic factors (age, tumor size, histological type, grade, anatomical status lymph nodes) were...

10.37358/rc.19.2.6936 article EN cc-by Revista de Chimie 2019-03-15

The incidence and characteristics of pediatric thrombotic events have become increasingly recognized, due to the enhanced utilization advanced diagnostic techniques. Pediatric thrombosis remains less frequent than in adults, often manifesting those with underlying congenital or acquired risk factors. This study aimed establish epidemiological data on Bihor County, Romania, highlighting challenges diagnosis smaller medical centers proposing a relevant treatment algorithm.

10.21873/invivo.13851 article EN In Vivo 2024-12-31

Microalbuminuria is a cardiovascular risk factor in type 2 diabetes mellitus patients. It very important to know which the predictor factors for albuminuria are, because these elements may be influenced by pharmacological measures. In our study we propose three models prediction of albumin glomerular excretion group 446 patients: clinical-biochemical model, and integrative model that reunites two models. was statistically significant HbA1c (positive correlation) blood pressure correlation)....

10.37358/rc.19.11.7650 article EN cc-by Revista de Chimie 2019-12-15
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