A5048990711- Prostate Cancer Treatment and Research
- Hormonal and reproductive studies
- Metabolism and Genetic Disorders
- Sexual Differentiation and Disorders
- Amino Acid Enzymes and Metabolism
- Complex Network Analysis Techniques
- Neonatal Health and Biochemistry
- Prostate Cancer Diagnosis and Treatment
- Genomics and Rare Diseases
- Opinion Dynamics and Social Influence
- Estrogen and related hormone effects
- SARS-CoV-2 and COVID-19 Research
- Bioinformatics and Genomic Networks
- Chalcogenide Semiconductor Thin Films
- Cancer Genomics and Diagnostics
- Nutrition, Genetics, and Disease
- Silicon and Solar Cell Technologies
- Quantum Dots Synthesis And Properties
- Genetics, Bioinformatics, and Biomedical Research
- Biochemical and Molecular Research
- Genetic Associations and Epidemiology
- RNA and protein synthesis mechanisms
- Silicon Nanostructures and Photoluminescence
- COVID-19 Clinical Research Studies
- Genetic factors in colorectal cancer
James Cook University
2013-2024
Australian Institute of Tropical Health and Medicine
2015-2024
United Nations Economic Commission for Latin America and the Caribbean
2024
FH Münster
2023
National Center for Epidemiology
2022
Országos Reumatológiai és Fizioterápiás Intézet
2022
John Wiley & Sons (United States)
2015-2020
Johns Hopkins University
2010-2020
Sidney Kimmel Comprehensive Cancer Center
2019-2020
Johns Hopkins Medicine
2019-2020
Starting from a general ansatz, we show how community detection can be interpreted as finding the ground state of an infinite range spin glass. Our approach applies to weighted and directed networks alike. It contains ad hoc introduced quality function [J. Reichardt S. Bornholdt, Phys. Rev. Lett. 93, 218701 (2004)] modularity $Q$ defined by Newman Girvan [Phys. E 69, 026113 special cases. The structure network is configuration that minimizes energy glass with states being indices. We...
A fast community detection algorithm based on a $q$-state Potts model is presented. Communities (groups of densely interconnected nodes that are only loosely connected to the rest network) found coincide with domains equal spin value in minima modified glass Hamiltonian. Comparing global and local Hamiltonian allows for overlapping (``fuzzy'') communities quantifying association multiple as well robustness community. No prior knowledge number has be assumed.
Human prostatic steroid 5α-reductase, encoded by the SRD5A2 gene on chromosome band 2p23, catalyses irreversible conversion of testosterone to dihydrotestosterone (DHT), most active androgen in prostate, with NADPH as its cofactor. This enzyme has never been purified but a number competitive inhibitors have developed for this since increased 5α-reductase activity may cause benign hypertrophy and prostate cancer. We report here detailed biochemical pharmacogenetic dissection human analysing...
PTEN is an important tumor-suppressor gene associated with many cancers. Through expression profiling of glioblastoma tissue samples and prostate cancer xenografts, we identified a molecular signature for loss the tumor suppressor in tumors. The consists minimum nine genes, several which are involved various pathways already implicated formation. Among these most significant was increase insulin growth factor-binding protein 2 (IGFBP-2) mRNA. Up-regulation IGFBP-2 confirmed at level by...
High-resolution Si $2p$ core-level spectra reveal a homogeneous broadening for amorphous compared to crystalline silicon. This is due static fluctuations in valence charges brought about by bond-length and bond-angle variations the network. The observed Gaussian of 256 meV corresponds mean deviation from charge neutrality approximately 0.11 elementary charges. addition hydrogen reduces \ensuremath{\sim}25%.
We describe the molecular characterization of two mutations responsible for galactosemia, an inherited disorder galatose metabolism that causes jaundice, cataracts, and mental retardation in humans. The coding region galactose-1-phosphate uridylyltransferase (GALT; UDPglucose:alpha-D-galactose-1-phosphate uridylyltransferase, EC 2.7.7.12) was amplified by polymerase chain reaction from total cDNA a classic galactosemic individual characterized direct sequencing products. Two missense were...
We solve the graph bipartitioning problem in dense graphs with arbitrary degree distribution using replica method. find cut size to scale universally <square root k> . In contrast, earlier results studying a Poissonian had found scaling square <k> [Fu and Anderson, J. Phys. A 19, 1605 (1986)]. Our also generalize of q partitioning. They can be used expected modularity Q [Newman Girvan, Rev. E 69, 026113 (2004)] random allow for assessment statistical significance output community detection...
DNA repair has been regarded as an important barrier to carcinogenesis. The newly discovered field of translesion synthesis (TLS) made it apparent that mammalian cells need distinct polymerases efficiently and accurately bypass lesions. Perturbation TLS polymerase activity by mutation, loss expression, etc. is expected result in the accumulation mutations exposed specific carcinogens. Furthermore, several can modulate cellular sensitivity chemotherapeutic agents. genes gene variations may...