A5042146182- Chemical Synthesis and Analysis
- Supramolecular Self-Assembly in Materials
- Polydiacetylene-based materials and applications
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Photochromic and Fluorescence Chemistry
- Innovative Microfluidic and Catalytic Techniques Innovation
- Axon Guidance and Neuronal Signaling
Center for Research in Molecular Medicine and Chronic Diseases
2021-2024
Universidade de Santiago de Compostela
2021-2024
Northwestern University
2023
Neurotrophic factors are essential not only for guiding the organization of developing nervous system but also supporting survival and growth neurons after traumatic injury. In central (CNS), inhibitory formation a glial scar injury hinder functional recovery neurons, requiring exogenous therapies to promote regeneration. Netrin-1, neurotrophic factor, can initiate axon guidance, outgrowth, branching, as well synaptogenesis, through activation deleted in colorectal cancer (DCC) receptors. We...
Abstract Light‐induced molecular piping of cyclic peptide nanotubes to form bent tubular structures is described. The process based on the [4+4] photocycloaddition anthracene moieties, whose structural changes derived from interdigitated flat disposition precursors corresponding cycloadduct induced geometrical modifications in packing that provokes their curvature. For this purpose, we designed a new class formed by β‐ and α‐amino acids. presence former predisposes stack parallel fashion...
In this protocol, we describe how to perform the photo-isomerization of cyclic peptides containing an unsaturated β-amino acid. This process triggers formation or disassembly peptide nanotubes under appropriate light irradiation. Specifically, start by describing solid-phase synthesis component. We also present a technique for performing isomerization studies in solution and extend it microfluidic aqueous droplets. For complete details on use execution please refer Vilela-Picos et al.
Abstract Light‐induced molecular piping of cyclic peptide nanotubes to form bent tubular structures is described. The process based on the [4+4] photocycloaddition anthracene moieties, whose structural changes derived from interdigitated flat disposition precursors corresponding cycloadduct induced geometrical modifications in packing that provokes their curvature. For this purpose, we designed a new class formed by β‐ and α‐amino acids. presence former predisposes stack parallel fashion...