A5076417343- Supramolecular Self-Assembly in Materials
- RNA Interference and Gene Delivery
- Psoriasis: Treatment and Pathogenesis
- IL-33, ST2, and ILC Pathways
- Advanced biosensing and bioanalysis techniques
- Polydiacetylene-based materials and applications
- Cancer Immunotherapy and Biomarkers
- Polymer crystallization and properties
- Infectious Aortic and Vascular Conditions
- Ion channel regulation and function
- Advanced Polymer Synthesis and Characterization
- Neuropeptides and Animal Physiology
- Endoplasmic Reticulum Stress and Disease
- Synthesis and biological activity
- Connective tissue disorders research
- Nerve injury and regeneration
- Pancreatic function and diabetes
- Monoclonal and Polyclonal Antibodies Research
- Neurogenesis and neuroplasticity mechanisms
- Bone Tissue Engineering Materials
- Advanced Sensor and Energy Harvesting Materials
- Cholesterol and Lipid Metabolism
- Liver Disease Diagnosis and Treatment
- biodegradable polymer synthesis and properties
- Aortic aneurysm repair treatments
Northwestern University
1995-2024
Fudan University
2016-2023
North China Electric Power University
2017
Fibril motion improves peptide signaling Artificial scaffolds that bear the peptide-signaling sequences of proteins for tissue regeneration often have limited effectiveness. Álvarez et al . synthesized supramolecular fibril bearing two promote nerve regeneration, one reduces glial scarring and another promotes blood vessel formation (see Perspective by Wojciechowski Stevens). In a mouse model paralyzing human spinal cord injury, mutations in tetrapeptide domain outside regions improved...
Supramolecular peptide chemistry offers a versatile strategy to create chemical systems useful as new biomaterials with potential deliver nearly 1000 known candidate therapeutics or integrate other types of bioactivity. We report here on the co-assembly lipidated β-sheet-forming peptides soluble short peptides, yielding supramolecular copolymers various degrees internal order. At low concentrations, co-monomer is protected by lodging within aqueous compartments and stabilizing β-sheets...
Supramolecular polymers, molecular assemblies bonded through directional non-covalent interactions, closely mimic the dynamic and adaptive behavior of biological nanofibers, such as those in cytoskeleton extracellular matrices. Despite their immense potential, complexity assembly pathways makes it highly challenging to unravel nature supramolecular dynamics within these aqueous environments. Here we introduce a precise combinatorial titration methodology probe situ process peptide...
Organic crystals formed by small molecules can be highly functional but are often brittle or insoluble structures with limited possibilities for use processing from a liquid phase. A possible solution is the nanoscale integration of polymers into organic without sacrificing long-range order and therefore function. This enables to benefit advantageous mechanical chemical properties polymeric component. We report here on strategy in which cocrystallize side chains chemically disordered create...
Neurotrophic factors are essential not only for guiding the organization of developing nervous system but also supporting survival and growth neurons after traumatic injury. In central (CNS), inhibitory formation a glial scar injury hinder functional recovery neurons, requiring exogenous therapies to promote regeneration. Netrin-1, neurotrophic factor, can initiate axon guidance, outgrowth, branching, as well synaptogenesis, through activation deleted in colorectal cancer (DCC) receptors. We...
An abdominal aortic aneurysm (AAA) is a localized dilation of the aorta located in abdomen that poses severe risk death when ruptured. The cause AAA not fully understood, but degradation medial elastin due to elastolytic matrix metalloproteinases key step leading dilation. Current therapeutic interventions are limited surgical repair prevent catastrophic rupture. Here, we report development injectable supramolecular nanofibers using peptide amphiphile molecules designed localize by targeting...
Supramolecular polymers are assemblies of monomers bonded non-covalently, thereby having potential to emulate the dynamic nature biological ones such as those in cytoskeleton, muscle, and extracellular matrices. Understanding dynamics synthetic analogues these is crucial develop adaptive functional biomaterials. Using three positively charged peptide amphiphiles, we introduce here a general base-titration methodology systematically decrease electrostatic repulsion among probe situ...
1. The requirement for extracellular Ca2+ in the process of evoked acetylcholine (ACh) release by nerve impulses was tested at endplates frog skeletal muscle. Ca(2+)‐containing lipid vesicles (Ca2+ liposomes) were used to elevate cytoplasmic concentrations under conditions which entry from fluid prevented. 2. In an solution containing no added and 1 mM Mg2+ (‘Ca(2+)‐free’ solution), liposomes promoted synchronous ACh quanta, reflected electrophysiologically as endplate potentials (EPPs),...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection relies on its spike protein binding to angiotensin-converting enzyme (ACE2) host cells initiate cellular entry. Blocking the interactions between and ACE2 offers promising therapeutic opportunities prevent infection. We report here peptide amphiphile supramolecular nanofibers that display a sequence from in order promote with SARS-CoV-2 receptor domain. demonstrate displaying this surface of assemblies preserves...
In order to generate cross sections for fast reactor calculation, a code named TXMAT based on object–oriented programming and allocate memory technology has been developed. It the capability macroscopic transport or diffusion calculation microscopic burnup can also deal with ultrafine group (more than 2000 groups P5 Legendre order) which TRANSX 2.15 can’t do. works together generalized section data library called MATXS give users easier access appropriate nuclear capabilities are difficult...
A series of <italic>N</italic>-biaryl amides were designed, quickly prepared by microwave-assisted solid-phase organic synthesis and phenotypically evaluated <italic>via</italic> mouse Th17 cell differentiation assay.
Cardiovascular disease remains a leading cause of global morbidity and mortality. Nanotechnology offers unique approach to treat atherosclerosis by targeting therapeutics sites interest, thereby avoiding side effects from systemic administration. A liver X receptor (LXR) α agonist, GW3965, was modified create drug-peptide conjugate (GW3965-V 2 E ) co-assembled with peptide amphiphile (PA) nanofiber displaying an apolipoprotein A1 (ApoA1)-mimetic sequence target atherosclerotic plaque. range...
The master transcription factor receptor retinoic acid receptor-related orphan γt (RORγt) regulates the differentiation of T-helper 17 (Th17) cells and production interleukin-17 (IL-17). Activation RORγt+ T in tumor microenvironment promotes immune infiltration to more effectively inhibit growth. Therefore, RORγt agonists provide a reachable approach cancer immunotherapy. Herein, series biaryl amide derivatives as novel were designed, synthesized, evaluated. Starting from reported inverse...