A5078826382- Bioinformatics and Genomic Networks
- Genomics and Phylogenetic Studies
- Genetics, Bioinformatics, and Biomedical Research
- Advanced Electron Microscopy Techniques and Applications
- Protein Structure and Dynamics
- Advanced X-ray Imaging Techniques
- Machine Learning in Bioinformatics
- Electron and X-Ray Spectroscopy Techniques
- Studies on Chitinases and Chitosanases
- Metabolomics and Mass Spectrometry Studies
- Electrohydrodynamics and Fluid Dynamics
- Lipid Membrane Structure and Behavior
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Plant Water Relations and Carbon Dynamics
- Microfluidic and Bio-sensing Technologies
- Fluid Dynamics and Turbulent Flows
- Insect symbiosis and bacterial influences
- Microbial Metabolic Engineering and Bioproduction
- Cell Image Analysis Techniques
- Mosquito-borne diseases and control
- Advanced Database Systems and Queries
- Science and Education Research
- Invertebrate Immune Response Mechanisms
- Biochemical and Structural Characterization
European Bioinformatics Institute
2020-2023
Universidade Federal de Minas Gerais
2017-2021
Abstract Public archiving in structural biology is well established with the Protein Data Bank (PDB; wwPDB.org) catering for atomic models and Electron Microscopy (EMDB; emdb-empiar.org) 3D reconstructions from cryo-EM experiments. Even before recent rapid growth cryo-EM, there was an expressed community need a public archive of image data experiments validation, software development, testing training. Concomitantly, proliferation imaging techniques cells, tissues organisms using volume EM...
Motivation: The Electron Microscopy Data Bank (EMDB) is a key repository for 3D electron microscopy (3DEM) data but lacks comprehensive annotations and connections to most of the related biological, functional, structural data. This limitation arises from optional nature such information reduce depositor burden complexity maintaining up-to-date external references, often requiring consent. To address these challenges, we developed EMICSS (EMDB Integration with Complexes, Structures,...
Cell membrane deformation is an important feature that occurs during many physiological processes, and its study has been put to good use investigate cardiomyocyte function. Several methods have developed extract information on contractility. However, no existing computational framework provided, in a single platform, straightforward approach acquire, process, quantify this type of cellular dynamics. For reason, we develop CONTRACTIONWAVE, high-performance software written Python programming...
Flaviviruses are responsible for serious diseases such as dengue, yellow fever, and zika fever. Their genomes encode a polyprotein which, after cleavage, results in three structural seven non-structural proteins. Homologous proteins can be studied by conservation coevolution analysis detected multiple sequence alignments, usually reporting positions which strictly necessary the structure and/or function of all members protein family or involved specific sub-class feature requiring residue...
Trypsin-like serine proteases are a group of homologous enzymes which exert multiple roles in both vertebrate and invertebrate organisms. Key properties these include their activation from an inactive zymogen form to active by cleavage residues N-terminus, the presence conserved catalytic triad residues, existence different patterns substrate selectivity for residue between various members this protein family. In article, we apply decomposition coevolution networks computational method find...
Abstract Summary CONAN is a web application developed to detect specificity determinants and function-related sites by amino acids co-variation networks analysis, emphasizing local coevolutionary constraints. The software allows the characterization of structurally functionally relevant groups residues their relationship with subsets sequences automatic cross-referencing GO terms, UniprotKb annotations INTERPRO. Availability implementation free open-source, being distributed in terms GPLV3...
Abstract Public archiving in structural biology is well established with the Protein Data Bank (PDB; wwPDB.org ) catering for atomic models and Electron Microscopy (EMDB; emdb-empiar.org 3D reconstructions from cryo-EM experiments. Even before recent rapid growth cryo-EM, there was an expressed community need a public archive of image data experiments validation, software development, testing training. Concomitantly, proliferation imaging techniques cells, tissues organisms using volume EM...
Computational studies of molecular evolution are usually performed from a multiple alignment homologous sequences, on which sequences resulting common ancestor aligned so that equivalent residues placed in the same position. Residues frequency patterns full or subset its can be highly useful for suggesting positions under selection. Most methods mapping co-evolving specificity determinant sites focused positions, however, they do not consider case determinants one subclass, but variable...
Voltage-gated sodium channels (Nav) are membrane proteins essential to initiating and propagating action potential in neurons other excitable cells. For a given organism there often multiple, specialized found different tissues, whose mutations can cause deleterious effects observed numerous diseases. Consequently, is high medical pharmacological interest these proteins. Scientific literature uses diagrams depict important patterns including the six transmembrane segments (S1–S6) present...
Abstract Background the scientific training to become a bioinformatician includes multidisciplinary abilities, which increase challenges professional development. Competition framework in order improve and promote ongoing of Brazilian bioinformatics community, we organize national competition, with main goal develop human resources abilities Computational Biology at level. The competition was designed three phases: 1) one-day challenge composed 60 multiple-choice questions covering Biology,...