A5066218248- Epigenetics and DNA Methylation
- Biofuel production and bioconversion
- Microbial Metabolic Engineering and Bioproduction
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Prenatal Substance Exposure Effects
- Identity, Memory, and Therapy
- Genetics, Bioinformatics, and Biomedical Research
- Fungal and yeast genetics research
- Sugarcane Cultivation and Processing
- Birth, Development, and Health
- Cancer, Stress, Anesthesia, and Immune Response
- Bioinformatics and Genomic Networks
- Salivary Gland Tumors Diagnosis and Treatment
- Family Support in Illness
- Plant Taxonomy and Phylogenetics
- Metastasis and carcinoma case studies
- Growth and nutrition in plants
- Biomedical and Engineering Education
- Neuropeptides and Animal Physiology
- Anesthesia and Neurotoxicity Research
- Fermentation and Sensory Analysis
- Diet and metabolism studies
- CRISPR and Genetic Engineering
- Childhood Cancer Survivors' Quality of Life
VA Connecticut Healthcare System
2021-2025
Yale University
2020-2025
National Center for Post Traumatic Stress Disorder
2023-2024
Connecticut Health Foundation
2021-2023
United States Department of Veterans Affairs
2023
National Center for PTSD
2023
Universidade Estadual de Campinas (UNICAMP)
2016-2022
Community Care
2021
Brazilian Center for Research in Energy and Materials
2019
Genomic (Brazil)
2019
The development of biocatalysts capable fermenting xylose, a five-carbon sugar abundant in lignocellulosic biomass, is key step to achieve viable production second-generation ethanol. In this work, robust industrial strain Saccharomyces cerevisiae was modified by the addition essential genes for pentose metabolism. Subsequently, taken through cycles adaptive evolution with selection optimal xylose utilization, strains could efficiently convert ethanol yield about 0.46 g ethanol/g xylose....
Abstract Opioid use disorder (OUD) is influenced by genetic and environmental factors. While recent research suggests epigenetic disturbances in OUD, this mostly limited to DNA methylation (5mC). hydroxymethylation (5hmC) has been widely understudied. We conducted a multi-omics profiling of OUD male cohort, integrating neuronal-specific 5mC 5hmC as well gene expression profiles from human postmortem orbitofrontal cortex (OUD = 12; non-OUD 26). Single locus methylomic analysis co-methylation...
Introduction DNA methylation (DNAm), an epigenetic mechanism, has been associated with opioid use disorder (OUD) in preclinical and human studies. However, most of the studies have focused on DNAm at CpG sites. non-CpG sites (mCpHs, where H indicates A, T, or C) recently shown to a role gene regulation be highly abundant neurons. its OUD is unknown. This work aims evaluate mCpHs postmortem orbital frontal cortex (OFC) context OUD. Methods A total 38 Postmortem OFC samples were obtained from...
β-thalassemia is a worldwide distributed monogenic red cell disorder, characterized by an absent or reduced beta globin chain synthesis. The unbalance of alpha-gamma and the presence pathological free iron promote severe oxidative damage, playing crucial role in erythrocyte hemolysis, exacerbating ineffective erythropoiesis decreasing lifespan blood cells (RBC). Catalase, glutathione peroxidase peroxiredoxins act together to protect RBCs from hydrogen peroxide insult. Among them, stand out...
Abstract Aging is a complex process with interindividual variability, which can be measured by aging biological clocks. clocks are machine-learning algorithms guided information and associated mortality risk wide range of health outcomes. One these transcriptomic clocks, uses gene expression data to predict age; however, their functional role unknown. Here, we profiled two (RNAAgeCalc knowledge-based deep neural network clock) in large dataset human postmortem prefrontal cortex (PFC)...
Ethanol production has key differences between the two largest producing countries of this biofuel, Brazil and USA, such as feedstock source, sugar concentration ethanol titers in industrial fermentation. Therefore, it is highly probable that these specificities have led to genome adaptation Saccharomyces cerevisiae strains employed each process tolerate different environments. In order identify particular adaptations, work, we compared genomes yeast widely used produce from sugarcane, corn...
Introduced concept of expected genotype quality (EGQ) and software to calculate it Provided read depth guidelines for GBS in tetraploids Developed generate diploidized calls from VCF files Demonstrated value aligning reads a mock reference genome SNP discovery Recommend filtering based on GQ prevent bias Although genotyping-by-sequencing (GBS) is well-established marker technology diploids, the development best practices tetraploid species topic current research. We determined theoretical...
Sugarcane hemicellulosic material is a compelling source of usually neglected xylose that could figure as feedstock to produce chemical building blocks high economic value, such xylitol. In this context, Saccharomyces cerevisiae strains typically used in the Brazilian bioethanol industry are robust chassis for genetic engineering, given their robustness towards harsh operational conditions and outstanding fermentation performance. Nevertheless, there no reports on use these xylitol...
Here, we report the genome assembly of a Saccharomyces cerevisiae SA1-derived haploid (FMY097) indigenous strain isolated from Brazilian ethanol distillery. FMY097 was recently reported to be highly aldehyde-resistant capable producing bioethanol in presence up 40 mM furfural and 80 5-hydroxymethylfurfural.
Background: Alcohol use disorder (AUD) is a complex condition associated with adverse health consequences that affect millions of individuals worldwide. Epigenetic modifications, including DNA methylation (5 mC), have been AUD and other alcohol-related traits. Epigenome-wide association studies (EWAS) identified differentially methylated genes in human peripheral brain tissue. More recently, epigenetic also evaluated hydroxymethylation hmC) the brain. However, most work postmortem tissue has...
This cross-sectional study uses data from 1135 male, European-American US military veterans to assess whether risk and protective factors influenced associations between posttraumatic stress disorder epigenetic age.
Soybean is the most important legume cropped worldwide and can highly benefit from biological nitrogen fixation (BNF) process. Brazil recognized for its leadership in use of inoculants two strains, Bradyrhizobium japonicum CPAC 15 (=SEMIA 5079) diazoefficiens 7 5080) compose majority 70 million doses soybean commercialized yearly country. We studied a collection natural variants these differing properties competitiveness efficiency BNF. sequenced genomes parental strain SEMIA 566 B....
Methylation patterns established and maintained at CpG sites may be altered by single nucleotide polymorphisms (SNPs) within these affect the regulation of nearby genes. Our aims were to: 1) identify generate a database SNPs potentially subject to epigenetic control DNA methylation via their involvement in creating, removing or displacing (meSNPs), and; 2) investigate association meSNPs with islands (CGIs), profiles extracted from tissues cattle divergent feed efficiencies detected using...