A5036512342- Epigenetics and DNA Methylation
- Genetic Syndromes and Imprinting
- Tryptophan and brain disorders
- Genetic Associations and Epidemiology
- Diet and metabolism studies
- Single-cell and spatial transcriptomics
- Adipose Tissue and Metabolism
- Memory and Neural Mechanisms
- Anesthesia and Neurotoxicity Research
- Substance Abuse Treatment and Outcomes
- Wildlife Ecology and Conservation
- Species Distribution and Climate Change
- Eicosanoids and Hypertension Pharmacology
- Prenatal Substance Exposure Effects
- Bat Biology and Ecology Studies
- Genetic diversity and population structure
- Stress Responses and Cortisol
- Amphibian and Reptile Biology
- Bioinformatics and Genomic Networks
- Neural dynamics and brain function
- Avian ecology and behavior
Yale University
2022-2024
Connecticut Health Foundation
2022-2024
Heidelberg University
2024
University Hospital Heidelberg
2024
VA Connecticut Healthcare System
2022-2024
Central Institute of Mental Health
2024
National Center for Post Traumatic Stress Disorder
2023-2024
Universidad San Francisco de Quito
2023
National Center for PTSD
2023
United States Department of Veterans Affairs
2023
Abstract Aging is a complex process with interindividual variability, which can be measured by aging biological clocks. clocks are machine-learning algorithms guided information and associated mortality risk wide range of health outcomes. One these transcriptomic clocks, uses gene expression data to predict age; however, their functional role unknown. Here, we profiled two (RNAAgeCalc knowledge-based deep neural network clock) in large dataset human postmortem prefrontal cortex (PFC)...
Background: Alcohol use disorder (AUD) is a complex condition associated with adverse health consequences that affect millions of individuals worldwide. Epigenetic modifications, including DNA methylation (5 mC), have been AUD and other alcohol-related traits. Epigenome-wide association studies (EWAS) identified differentially methylated genes in human peripheral brain tissue. More recently, epigenetic also evaluated hydroxymethylation hmC) the brain. However, most work postmortem tissue has...
Abstract Structural and functional changes of the brain are assumed to contribute excessive cocaine intake, craving, relapse in use disorder (CUD). Epigenetic transcriptional were hypothesized as a molecular basis for CUD-associated alterations. Here we performed multi-omics study CUD by integrating epigenome-wide methylomic (N=42) transcriptomic (N=25) data from same individuals using postmortem tissue Brodmann Area 9 (BA9). Of N=1,057 differentially expressed genes (p<0.05), one gene,...
Structural and functional changes of the brain are assumed to contribute excessive cocaine intake, craving, relapse in use disorder (CUD). Epigenetic transcriptional were hypothesized as a molecular basis for CUD-associated alterations. Here we performed multi-omics study CUD by integrating epigenome-wide methylomic (N = 42) transcriptomic 25) data from same individuals using postmortem tissue Brodmann Area 9 (BA9). Of N 1 057 differentially expressed genes (p < 0.05), one gene, ZFAND2A, was...
Background Pristimantis is the most diverse genus of terrestrial frogs. Historically, it has been divided into several phenetic groups in order to facilitate species identification. However, light phylogenetic analysis, many these have shown be non-monophyletic, denoting a high degree morphological convergence and limited number diagnostic traits. In this study, we focus on myersi group, an assemblage small rainfrogs distributed throughout Andes Ecuador Colombia, whose external morphology...
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1 Abstract Alcohol use disorder (AUD) is a complex condition associated with adverse health consequences that affect millions of individuals worldwide. Epigenetic modifications, including DNA methylation (5mC), have been AUD and other alcohol-related traits. Epigenome-wide association studies (EWAS) identified differentially methylated genes in human peripheral brain tissue. More recently, epigenetic also evaluated hydroxymethylation (5hmC) the brain. However, most work postmortem tissue has...