A5084653301- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Receptor Mechanisms and Signaling
- Epigenetics and DNA Methylation
- Neurotransmitter Receptor Influence on Behavior
- Cell Image Analysis Techniques
- SARS-CoV-2 detection and testing
- Genetic Associations and Epidemiology
- Resilience and Mental Health
- Genetic Syndromes and Imprinting
- Biosensors and Analytical Detection
- Identity, Memory, and Therapy
- COVID-19 diagnosis using AI
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- interferon and immune responses
- Posttraumatic Stress Disorder Research
- Influenza Virus Research Studies
- vaccines and immunoinformatics approaches
- Genetic Mapping and Diversity in Plants and Animals
- Genetics, Aging, and Longevity in Model Organisms
- Grief, Bereavement, and Mental Health
- Personality Disorders and Psychopathology
- Autism Spectrum Disorder Research
Heidelberg University
2024-2025
University Hospital Heidelberg
2024-2025
Central Institute of Mental Health
2024-2025
National Academy of Sciences of Armenia
2014-2024
Institute of Molecular Biology
2018-2024
University of California, San Diego
2024
Russian-Armenian University
2021-2022
Palacký University Olomouc
2019
Epigenome, transcriptome, and proteome analyses of postmortem brains have revealed initial molecular insights into cocaine use disorder (CUD). However, the inter-relationship between these omics contribution individual cell types remains largely unknown. We present an in-depth analysis changes in ventral striatum CUD at multi-omics single-cell resolution. Integrative microRNA sequencing (microRNA-seq), RNA (RNA-seq), proteomics datasets 41 individuals single-nuclei RNA-seq a subset 16...
The sequencing of SARS-CoV-2 provides essential information on viral evolution, transmission, and epidemiology. In this paper, we performed the whole-genome using nanopore Illumina to describe circulation virus lineages in Armenia. analysis 145 full genomes identified six clades (19A, 20A, 20B, 20I, 21J, 21K) considerable intra-clade PANGO lineage diversity. Phylodynamic transmission allowed attribute specific as well infer their importation routes. Thus, first two waves positive case...
Abstract Background The occurrence of post-traumatic stress disorder (PTSD) following a traumatic event is associated with biological differences that can represent the susceptibility to PTSD, impact trauma, or sequelae PTSD itself. These effects include in DNA methylation (DNAm), an important form epigenetic gene regulation, at multiple CpG loci across genome. Moreover, these be shared specific both central and peripheral tissues. Here, we aim identify blood DNAm characterize underlying...
Structural and functional changes of the brain are assumed to contribute excessive cocaine intake, craving, relapse in use disorder (CUD). Epigenetic transcriptional were hypothesized as a molecular basis for CUD-associated alterations. Here we performed multi-omics study CUD by integrating epigenome-wide methylomic (N = 42) transcriptomic 25) data from same individuals using postmortem tissue Brodmann Area 9 (BA9). Of N 1 057 differentially expressed genes (p < 0.05), one gene, ZFAND2A, was...
Abstract Structural and functional changes of the brain are assumed to contribute excessive cocaine intake, craving, relapse in use disorder (CUD). Epigenetic transcriptional were hypothesized as a molecular basis for CUD-associated alterations. Here we performed multi-omics study CUD by integrating epigenome-wide methylomic (N=42) transcriptomic (N=25) data from same individuals using postmortem tissue Brodmann Area 9 (BA9). Of N=1,057 differentially expressed genes (p<0.05), one gene,...
With the emergence of severe acute respiratory syndrome-related coronavirus (SARS-CoV-2), antiviral drug development has gained increased significance due to high incidence and potentially complications resulting infection. Heterocycle compounds, acting as antimetabolites DNA RNA monomers, rank among most effective drugs. These compounds' effects on various SARS-CoV-2 isolates, found in existing data collections, form basis for further research. The aim this study was examine possible effect...
<title>Abstract</title> Structural and functional alterations in the brain's reward circuitry are present cocaine use disorder (CocUD), but their molecular underpinnings remain unclear. To investigate these mechanisms, we performed single-nuclei multiome profiling on postmortem caudate nucleus tissue from six individuals with CocUD eight controls. We profiled 31,178 nuclei, identifying 13 cell types including D1- D2-medium spiny neurons (MSNs) glial cells. observed 1,383 differentially...
Background: Posttraumatic stress disorder (PTSD) is an anxiety disease influenced by both environmental and genetic factors, which affects a patient’s quality of life social stability. Recent studies have shown that the pathogenesis PTSD associated with apoptosis; however, molecular mechanisms cause such damage are not well-understood. Also it unclear whether these pathologic alterations genetically determined or caused other factors. The aim this study was to investigate association...
Abstract Epigenome, transcriptome, and proteome analyses of postmortem brains have revealed initial molecular insights into cocaine use disorder (CUD). However, the inter-relationship between these –omics contribution individual cell types remain largely unknown. We present an in-depth analysis changes in ventral striatum CUD at multi-omics single-cell resolution. Integrative microRNA-seq, RNA-seq, proteomics datasets 41 individuals single-nuclei RNA-seq a subset 16 conserved deregulation...
Abstract Environmental and genetic risk factors contribute to the development of borderline personality disorder (BPD). We conducted largest GWAS BPD date, meta-analyzing data from 12,339 cases 1,041,717 controls European ancestry, identified six independent associated genomic loci, nine genes in gene-based analysis. observed a single-nucleotide polymorphism (SNP) heritability 17.3% derived polygenic scores (PGS) predicted 4.6% phenotypic variance case-control status. showed strongest...
Background: Posttraumatic stress disorder (PTSD) is a complex severe polygenic psychiatric disease, influenced by environmental and genetic factors. PTSD development progression characterized cognitive impairment, which may result in altered processes of nervous system synaptic plasticity, where number growth factors their receptors were shown to play important role. Since neurotrophins an essential role the central system, it widely implicated disorders. The aim this study investigate...
Abstract COVID-19 pandemic severely impacted the healthcare and economy on a global scale. It is widely recognized that mass testing an efficient way to contain infection spread as well development of informed policies for disease management. However, current worldwide rates increased demand in rapid reliable screening SARS-CoV-2 infection. We compared performance qRT-PCR direct heat-inactivated, heat-inactivated/pelleted samples against RNA group 74 subjects (44 positive 30 negative). In...
Abstract Sequencing of SARS-CoV-2 provides essential information into viral evolution, transmission, and epidemiology. Short-read next-generation sequencing platforms are currently the gold-standard approaches characterized by highest accuracy. Meanwhile, Oxford Nanopore’s long-read devices show great promise, offering comparable accuracy, fast turnaround time, reduced cost. In this study, we performed whole-genome molecular-genetic characterization from clinical specimens using an...
<ns4:p><ns4:italic><ns4:bold>Background</ns4:bold>:</ns4:italic>Alflatoxin B1 (AFB1) is the most hepatotoxic and hepatocarcinogenic of aflatoxins occurs as a contaminant in variety foods. The toxicity AFB1 has been shown to be associated with wide range pathological events, such enhanced apoptosis oxidative events. Currently there no treatment for mycotoxin exposure. aim this study was evaluate potential ability picolinyl-L-phenylalaninate (PLP), picolinyl-L-tryptophanate (PLT),...