A5062946525- Amyotrophic Lateral Sclerosis Research
- Parkinson's Disease Mechanisms and Treatments
- Neurological diseases and metabolism
- Advanced Neuroimaging Techniques and Applications
- Neurogenetic and Muscular Disorders Research
- Prion Diseases and Protein Misfolding
- Genetic Neurodegenerative Diseases
- Alzheimer's disease research and treatments
- Neonatal Respiratory Health Research
- Functional Brain Connectivity Studies
- Spinal Dysraphism and Malformations
- Neurological and metabolic disorders
- S100 Proteins and Annexins
- Facial Rejuvenation and Surgery Techniques
- Parkinson's Disease and Spinal Disorders
- Botulinum Toxin and Related Neurological Disorders
- CNS Lymphoma Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Peripheral Neuropathies and Disorders
- Glioma Diagnosis and Treatment
- Neurological disorders and treatments
- Myasthenia Gravis and Thymoma
- Pregnancy and preeclampsia studies
- Pancreatic function and diabetes
- Healthcare Decision-Making and Restraints
Ospedale Sant'Anna
2022-2023
University of Naples Federico II
2010-2016
University of Campania "Luigi Vanvitelli"
2010-2015
International Neuromodulation Society
2013
Associazione Italiana Sclerosi Multipla
2012
Università Cattolica del Sacro Cuore
1995
Objective To identify shared polygenic risk and causal associations in amyotrophic lateral sclerosis (ALS). Methods Linkage disequilibrium score regression Mendelian randomization were applied a large‐scale, data‐driven manner to explore genetic correlations relationships between >700 phenotypic traits ALS. Exposures consisted of publicly available genome‐wide association studies (GWASes) summary statistics from MR Base LD‐hub . The outcome data came the recently published ALS GWAS...
<h3>BACKGROUND AND PURPOSE:</h3> The extensive application of advanced MR imaging techniques to the study ALS has undoubtedly improved our knowledge disease pathophysiology, even if actual spread neurodegenerative process throughout central nervous system is not fully understood. present aimed detect WM patterns microstructural abnormalities better investigate pathologic in ALS, within but also beyond CSTs, a whole-brain analysis. <h3>MATERIALS METHODS:</h3> DTI was performed 19 patients...
Neurodegenerative process in amyotrophic lateral sclerosis (ALS) has been proven to involve several cortical and subcortical brain regions within beyond motor areas. However, how ALS pathology spreads progressively during disease evolution is still unknown. In this cross-sectional study we investigated 54 patients, divided into 3 subsets according the clinical stage, 18 age sex-matched healthy controls, by using tract-based spatial statistics (TBSS) diffusion tensor imaging (DTI) voxel-based...
In amyotrophic lateral sclerosis (ALS), diffusion weighted magnetic resonance imaging (DW-MRI) has produced mounting evidence of a widespread white matter (WM) damage within motor and extramotor pathways. To provide novel information about the degenerative process in ALS, overcoming some limitations imposed by tensor (DTI), we performed high angular resolution (HARDI) analysis DW-MRI data. Generalized fractional anisotropy (GFA) was evaluated 19 patients with ALS matched control subjects,...
Background and purpose: The growth hormone (GH) insulin‐like factor (IGF) system may be involved in neurodegenerative processes, some abnormalities have been reported amyotrophic lateral sclerosis (ALS). Our aim was to investigate the GH–IGF axis patients with ALS evaluate correlations between this endocrine clinical features. Methods: Serum levels of GH , IGF ‐ I II insulin, IGF‐binding protein 1 (IGF‐BP1), 3 (IGF‐BP3) were measured 25 age‐, gender‐, BMI‐matched healthy controls. A GHRH...
Emerging evidence shows that cognitive deficits associated with frontal lobe dysfunction occur from early stages of amyotrophic lateral sclerosis (ALS). We aimed to assess neuropsychological functioning at different ALS further delineate the occurrence impairment alongside trajectory as defined by standard assessment procedures. investigated several domains in 74 patients classified into four clinical disease, according a recently validated staging system for (known 'King's' system), and...
The concurrence of amyotrophic lateral sclerosis (ALS) and multiple (MS) is extremely rare. We reported the case a 33-year-old woman with past history paresthesias at right hand, who developed progressive quadriparesis muscular atrophy limbs and, finally, bulbar signs dyspnea. Clinical neurophysiologic investigations revealed upper lower motor neuron in region extremities, suggesting diagnosis ALS. Moreover, magnetic resonance imaging (MRI) cerebrospinal fluid (CSF) analysis demonstrated 3...
Background.Physical activity and occupational exposures appeared to play a relevant role in pathogenesis of amyotrophic lateral sclerosis (ALS), neurodegenerative disease unknown origin.Materials methods.We aimed make an overview the clinical characteristics lifestyle (occupation sport) population 395 patients with ALS from campania, southern Italy.Results.ALS onset resulted anticipated about 11 years industry workers, whilst more frequent site among farmers was upper limbs.compared...
Abstract Background Law 219/2017 was approved in Italy December 2017, after a years-long debate on the autonomy of healthcare choices. This Law, for first time Italian legislation, guarantees patient’s right to request withdrawal life-sustaining treatments, including mechanical ventilation (MV). Objective To investigate current status MV amyotrophic lateral sclerosis (ALS) patients and assess impact this practice. Methods We conducted Web-based survey, addressed neurologists with expertise...
Abstract Background Diabetic Striatopathy (DS) is a rare complication of poor‐controlled Diabetes Mellitus consisting sudden onset movement disorders. To date, there still poor knowledge about the pathogenesis. Case We describe 79 year old men affected by hemichoreic movements whose cause was non‐ketotic hyperglycaemia diagnosed despite normal blood glucose levels thanks to brain CT and magnetic resonance imaging. Then, we introduce new spectroscopy (MRS) finding never described until today...
We examined the in vitro effect of human growth hormone (hGH) on placental production and modulation by opioids this function. Small fragments from 12 term placentas were incubated at 37°C a 95% air 5% CO2 atmosphere for 4 h with various concentrations hGH (1–1000 ng/ml) or naloxone (3–500 ng/ml). Both increased chorionic gonadotropin (hCG) progesterone media. The was dose-dependent statistically significant 10 ng/ml, while able to increase hCG only highest doses (250–500 concomitant...
According to the last Italian report by Ministry of Health in 2018, estimated number acute ischemic strokes (AIS) Campania is 10,000/year, with an expected 1390 intravenous thrombolysis (IVT) and 694 mechanical thrombectomies (MT). In 2017, only 1.5% patients received IVT 0.2% MT. This study analyzed trend MT 2019-2020 depicted state art Stroke Care Campania.From regional health task force, we obtained hospital discharge forms from all private public hospitals Campania; selected a principal...
Myasthenia Gravis (MG) is a neuromuscular junction disease, for which the most specific test an increase in anti-acetylcholine receptor antibodies (anti-ACHR-Abs) titer.Myasthenic symptoms are rarely detected patients with Amyotrophic Lateral Sclerosis (ALS).We report case of patient sporadic ALS who presented at onset clinical and instrumental features suggestive disorder junction.She was treated intravenous immunoglobulins two years, sensitive improvement strength delay disease...