Background: The aim of this study was to determine if fracture reduction, pattern, and patient-related factors influence clinical outcome after locked-plate fixation displaced proximal humeral fractures. Methods: Ninety-eight patients (mean age, 61.1 ± 11.2 years) with a involving the anatomical neck (type C according OTA/AO classification system) were included. Clinical determined by age sex-adjusted Constant score (CS%) Disabilities Arm, Shoulder Hand (DASH) score. Fracture reduction...

Background: Bone-graft substitutes are commonly used for the augmentation of traumatic bone defects in tibial plateau fractures. However, their clinical performance compared with that autologous bone-grafting, gold standard defect reconstruction, still remains under debate. This study investigates differences quality life, pain, and radiographic outcomes treatment fracture-associated either grafts or a bioresorbable hydroxyapatite calcium sulfate cement (CERAMENT BONE VOID FILLER [CBVF];...

Abstract Objective The nucleus pulposus (NP) of the intervertebral disc develops from notochord. Humans and other species in which notochordal cells (NCs) disappear to be replaced by chondrocyte‐like mature NP (MNPCs) frequently develop degeneration, unlike that retain NCs. reasons for NC disappearance are unknown. In humans, change cell phenotype (to MNPCs) coincides with changes decrease nutrient supply avascular disc. We undertook this study test hypothesis consequent stress could...

In Brief Study Design. An in vivo study on the rabbit lumbar spine model. Objectives. Effects of temporary dynamic distraction intervertebral discs were studied model to characterize changes associated with disc and evaluate feasibility previously compressed order stimulate regeneration. Summary Background Data. Studies have shown that accelerated degeneration results from altered mechanical loading conditions. The development methods for prevention restoration tissue has already degenerated...

Conservative treatment of simple elbow dislocations can lead to complications such as persisting pain and restricted joint mobility. The current aim was identify patients with deteriorated outcome after conservative investigate a possible association initial (in)stability.Sixty-eight (mean age 37.1 ± 17.2 years) received treatment. After closed reduction, stability tested by varus valgus stress under fluoroscopy. According the findings fluoroscopy, three different groups instability could be...

In Brief Study Design. An animal model of degeneration was used to determine the effects disc distraction, and evaluated with magnetic resonance imaging (MRI) as well gene protein expression levels. Objective. To investigate MRI distraction. Summary Background Data. Disc can result from hyper-physiologic loading. Distracted discs showed histologic signs tissue recovery. Methods. There were 18 rabbits that underwent 28 days compression (200 N) induce moderate followed by distraction (120 N;...

Avascular necrosis (AVN) of the humeral head is a severe complication after proximal humerus fracture dislocations, and leads to poorer clinical outcome subsequent revision surgeries. The aim current study was analyze influence time surgery on AVN rate locked plating dislocation fractures humerus. This retrospective included 30 patients with mean age 63 ± 14 years type B3 or C3 according AO/OTA classification. rates were determined clinically radiographically. In addition, using Constant...

In Brief Study Design. vivo animal study. Objectives. To describe a new porcine disc degeneration model, and to analyze remodeling after nucleotomy with special view the different nucleus pulposus (NP) cell types. Summary of Background Data. Thus far, predominantly smaller animals were used for models; however, such small discs inappropriate investigate implementation therapies. Though notochordal cells (NCs) are important formation maintenance, differences in amount NCs between human have...

Background and purpose — Delayed bone healing with non-union is a common problem. Further options to increase together surgery are needed. We therefore evaluated 1-dose single application of erythropoietin (EPO), applied either locally the defect or systemically during surgery, in critical-size rabbit long-bone defect. Material methods 19 New Zealand White rabbits received 15-mm radius diaphysis. An absorbable gelatin sponge was soaked saline (control group systemic treatment group) EPO...

An external compression model was used to evaluate gene and protein expression in intervertebral discs with moderate disc degeneration.To determine messenger ribonucleic acid levels of relevant components.An animal mechanically induced degeneration developed characterized histologically. However, little is known at the molecular level degeneration.There were 8 New Zealand white rabbits subjected monosegmental posterior induce degeneration. Twelve animals served as controls or sham controls....

The aim of this study was to investigate the outcomes in a large series Essex-Lopresti injuries (ELIs) and compare patients with early late diagnoses.Thirty-one an ELI (average age standard deviation [SD], 46 ± 10 years) who were followed for minimum 2 years included study. Patients grouped according whether had been diagnosed (on day injury) or (>4 weeks after radial head injury). Acute treatment early-diagnosed temporary stabilization distal radioulnar joint (DRUJ) by Kirschner wires...

Abstract The objective of the study was to improve biological understanding degenerative disc disease using a rabbit model in which different stages degeneration are induced by variation duration loading with an external compression‐device applying 2.4 MPa. Gene expression and protein distribution were analyzed controls after 1, 28, 56 days hyperphysiologic loading. To evaluate extracellular matrix genes, quantitative real‐time reverse‐transcriptase polymerase chain reaction applied for...

Clavicle non-unions can occur after both conservative and operative treatment failure. Here, we investigated the outcome of patients with delayed fracture healing or clavicle. Patients underwent revision surgery by plate osteosynthesis clavicle without bone grafting. Our aim was to determine rates functional long-term outcome.The study population 58 consecutive divided into group 1 (n = 25; no graft) 2 33; iliac crest graft). Bone consolidation determined Lane-Sandhu score preoperatively 2.2...

The primary objective of this study was to assess the interobserver and intraobserver agreement on ligamentous injuries conventional magnetic resonance imaging (MRI) in acute simple elbow dislocation. secondary objectives were determine assessment joint congruity, effusion, loose bodies chondral lesions MRI. Conventional MRIs (1.5 Tesla, specific surface coil) 30 patients (40.7 years; range 14–72) with dislocations evaluated by four blinded examiners. An analysis all raters for several...