A5079810240- Statistical Methods in Clinical Trials
- Health Systems, Economic Evaluations, Quality of Life
- Optimal Experimental Design Methods
- Advanced Causal Inference Techniques
- Orthopedic Surgery and Rehabilitation
- VLSI and Analog Circuit Testing
- Atrial Fibrillation Management and Outcomes
- Hydraulic Fracturing and Reservoir Analysis
- Reservoir Engineering and Simulation Methods
- Elbow and Forearm Trauma Treatment
- Shoulder Injury and Treatment
- Educational Robotics and Engineering
- Bone fractures and treatments
- Advanced Statistical Process Monitoring
- Hydrocarbon exploration and reservoir analysis
- Radiation Effects in Electronics
- Intracerebral and Subarachnoid Hemorrhage Research
- Eating Disorders and Behaviors
- Cardiac Imaging and Diagnostics
- Aluminum Alloys Composites Properties
- Advanced Multi-Objective Optimization Algorithms
- Obesity and Health Practices
- Meta-analysis and systematic reviews
- Acute Ischemic Stroke Management
- Prenatal Screening and Diagnostics
Friedrich-Alexander-Universität Erlangen-Nürnberg
2023
Heidelberg University
2014-2021
Zimmer Biomet (Germany)
2015-2021
University Hospital Heidelberg
2021
Seoul Medical Center
2016
University of Oxford
2000
ExxonMobil (United States)
1972-1998
University of Wisconsin–Milwaukee
1978
In clinical trials, the opportunity for an early stop during interim analysis (either efficacy or futility) may relevantly save time and financial resources. This is especially important, if planning assumptions required power calculation are based on a low level of evidence. For example, when including two primary endpoints in confirmatory analysis, trial depends effects both their correlation. Assessing feasibility such therefore difficult, as number parameter to be correctly specified...
Background and purpose To determine the rate of peri‐interventional silent brain infarcts after left atrial appendage occlusion ( LAAO ). Methods In this prospective, uncontrolled single‐center pilot study, consecutive patients with fibrillation undergoing between July 2013 January 2016 were included. The Amplatzer Cardiac Plug, WATCHMAN or Amulet device was used. A neurological examination cranial magnetic resonance imaging MRI ) performed within 48 h before procedure. evaluated for new...
The primary objective of this study was to assess the interobserver and intraobserver agreement on ligamentous injuries conventional magnetic resonance imaging (MRI) in acute simple elbow dislocation. secondary objectives were determine assessment joint congruity, effusion, loose bodies chondral lesions MRI. Conventional MRIs (1.5 Tesla, specific surface coil) 30 patients (40.7 years; range 14–72) with dislocations evaluated by four blinded examiners. An analysis all raters for several...
Background: Revision rates following radial head arthroplasty (RHA) for unreconstructible fractures (RHFs) differ vastly in the literature, and little is known about risk factors that are associated with revision surgery. The purposes of this study were to assess rate RHA determine factors. Methods: A total 122 patients (mean age, 50.7 years; range, 18 79 years) 123 RHAs who underwent RHFs between 1994 2014 ≥3 years out from surgery included. Demographic variables, injury procedure-related...
Anastomotic leakage constitutes a dreaded complication after colorectal surgery, leading to increased morbidity and mortality as well prolonged hospitalization. Most leakages become clinically apparent about 8 days surgery; however, early detection is quintessential reduce complications improve patients' outcome. We therefore investigated the significance of specific protein expression profiles putative biomarkers, indicating anastomotic leakage.In this single-center prospective cohort study...
Abstract Background Stigmatization and discrimination of people with obesity due to their weight are a common problem that may lead additional gain. This study evaluated the influence different parameters on stigmatization obesity. Material Methods Participants six groups (general population, patients obesity, medical students, physicians, nurses in training nurses; n = 490) answered short-form fat phobia scale (FPS) between August 2016 July 2017. The body mass index (BMI), gender other...
<b><i>Background:</i></b> Prothrombin complex concentrates (PCCs) are frequently used to reverse the effect of vitamin K antagonists (VKAs) in patients with non-traumatic intracerebral hemorrhage (ICH). However, information on rate thromboembolic events (TEs) and allergic after PCC therapy VKA-ICH is limited. <b><i>Methods:</i></b> Consecutive treated at our institution between December 2004 June 2014 were included into this retrospective...
Risk factors for primary non-melanoma skin cancer (NMSC) in organ transplant recipients (OTR) have been well described. Data subsequent NMSC and dynamics their occurrence OTR are limited.To study long-term risks of associated risk OTR.A retrospective single-centre cohort analysing medical records from a dermato-oncological specialty clinic.Of 464 110 (23.7%) developed at least one, 73 (15.7%) two 51 (11%) three during median follow-up 9.6 years. Cumulative incidences 5, 10 15 years were...
Aims Complex joint fractures of the lower extremity are often accompanied by soft-tissue swelling and associated with prolonged hospitalization complications. The aim study was to evaluate effect vascular impulse technology (VIT) on conditioning in comparison conventional elevation. Methods A total 100 patients were included this prospective, randomized, controlled monocentre allocated three subgroups dislocated ankle fracture (n = 40), pilon 20), intra-articular calcaneal 40). Patients...
The aim of this study was to develop and validate a novel self-administered questionnaire for assessing the patient's own range motion (ROM) wrist elbow. In prospective clinical from January 2015 June 2015, 101 consecutive patients were evaluated with novel, self-administered, diagram-based, assessment score (W-MAS) elbow (E-MAS). statistically test-retest reliability, patient-physician agreement, comparison healthy population, influence covariates (age, gender, affected side involvement in...
Fractures of the extremities are often complicated by a variable degree swelling secondary to hemorrhage and soft tissue injury. Patients typically require up 7 days inpatient bed rest elevation reduce an acceptable level for operative treatment with internal fixation. Alternatively, intermittent pneumatic compression device, such as Vascular Impulse Technology (VIT) system, can be used at injured extremity posttraumatic swelling. The VIT system consists compressor that intermittently...
In clinical trials, the choice of an adequate primary endpoint is often difficult. Besides its relevance, must be measurable within reasonable time and allow differentiating between treatments. Often, most relevant ‘’time-to-death,” but if overall survival prognosis good, only a few deaths are observed during study duration. A possible solution to use surrogate endpoints instead. However, various examples from literature demonstrate that surrogates do not always perform as intended....
To determine an optimum production strategy, areal two-dimensional gas-water model, cross-sectional studies, and a coning model were used. history match showed appreciable horizontal water influx. Water coning, however, would not be problem, channeling could overcome by additional perforating. Ultimate gas recovery can considerably increased if withdrawal rates are kept high. Introduction Until imported is available in Bavaria, the present measure for filling gap between increasing demand...
Journal Article Psychosocial Perceptions of the Nusing Home: A Comparative Analysis Staff, Resident, and Cross-generational Perspectives Get access John M. O'Donnell, PhD, PhD 2204 E. Capitol Dr., Milwaukee 53212 Search for other works by this author on: Oxford Academic PubMed Google Scholar Joseph L. Collins, EdD, EdD 31200 Susan Schuler, MS 4School Nursing, Univ. Wisconsin-Milwaukee The Gerontologist, Volume 18, Issue 3, June 1978, Pages 267–271, https://doi.org/10.1093/geront/18.3.267...
Background: Cognitive dysfunction is a frequent phenomenon after surgical and cardiovascular interventions. No data on cognitive function left atrial appendage occlusion (LAAO) are available so far. The aim of the present study was to evaluate LAAO compared before LAAO. Methods findings: Patients who underwent for treatment fibrillation at Heidelberg Department Internal Medicine III were eligible this observational, explorative, single-center, non-randomized cohort study, between July 2013...