A5060999998- Oral microbiology and periodontitis research
- Immune Response and Inflammation
- Immunodeficiency and Autoimmune Disorders
- Oral Health Pathology and Treatment
- Streptococcal Infections and Treatments
- Herpesvirus Infections and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- HIV/AIDS oral health manifestations
- Neuropeptides and Animal Physiology
- Cytomegalovirus and herpesvirus research
- Blood disorders and treatments
- Biochemical and Structural Characterization
- Tracheal and airway disorders
- Esophageal and GI Pathology
- HIV Research and Treatment
- Systemic Lupus Erythematosus Research
- Lipid Membrane Structure and Behavior
- Dental Health and Care Utilization
- Cancer Diagnosis and Treatment
- Antimicrobial Peptides and Activities
- Salivary Gland Disorders and Functions
- vaccines and immunoinformatics approaches
- Oral and gingival health research
- Psoriasis: Treatment and Pathogenesis
Colgate-Palmolive (United States)
2021
Syneos Health (United States)
2021
University of Pennsylvania
2014-2015
Philadelphia University
2015
University of Washington
2011-2013
Fred Hutch Cancer Center
2010
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2009
Inflammatory bone loss from periodontal infections in leukocyte adhesion deficiency disease can be reversed by treatment with antibodies to IL-17 or IL-23.
The oral and intestinal host tissues both carry a heavy microbial burden. Although commensal bacteria contribute to healthy tissue structure function, their contribution health is poorly understood. A crucial component of periodontal the recruitment neutrophils tissue. To elucidate this process, gingival specific-pathogen-free germ-free wild-type mice CXCR2KO MyD88KO were examined for quantitative analysis CXCR2 chemoattractants (CXCL1, CXCL2). We show that does not require bacterial...
Significance Experimental gingivitis studies where dental hygiene is withheld from select teeth, allowing natural bacterial accumulation, provide a unique opportunity to study the reversible transition health inflammatory disease in humans. Longitudinal analysis of both microbial and host changes during human experimental revealed previously unknown variation response succession sequence inflammation. The significance our findings can be summarized two major points. First, comprehensively...
ABSTRACT Periodontitis is a disease of polymicrobial etiology characterized by inflammation, degradation host tissue, and bone that irreversibly destroys the supporting apparatus teeth. Porphyromonas gingivalis contains lipid A with structural heterogeneity has been postulated to contribute initiation dysbiosis in oral communities modulating response, thereby creating permissive environment for its growth. We examined two P. phosphatase mutants which contain different “locked” structures...
Background Potently-neutralizing, anti-MPER humoral responses are uncommon in AIDS patients, though some antibodies, like 4E10, broadly cross-reactive and protective combination passive immunizations. The difficulty raising these specificities may be the result of steric occlusion this region on virions and/or 'masking' epitopes by means; understanding mechanisms, mechanisms which antibodies neutralize, critical selection design vaccine immunogens targeting region.