A5048716954- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Hormonal and reproductive studies
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Urinary Tract Infections Management
- HIV Research and Treatment
- Diphtheria, Corynebacterium, and Tetanus
- Global Cancer Incidence and Screening
- Urological Disorders and Treatments
- Stress Responses and Cortisol
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Urinary Bladder and Prostate Research
- Bacteriophages and microbial interactions
- Colorectal Cancer Screening and Detection
- Pancreatic function and diabetes
- Nitric Oxide and Endothelin Effects
- Testicular diseases and treatments
- Metabolism, Diabetes, and Cancer
- Urologic and reproductive health conditions
- Cancer, Lipids, and Metabolism
- Surgical site infection prevention
- Pelvic floor disorders treatments
- Metal-Catalyzed Oxygenation Mechanisms
Waikato Hospital
2001-2022
University of Auckland
2014
University of Waikato
2014
Roswell Park Comprehensive Cancer Center
2013
University of California, San Diego
2013
Fred Hutch Cancer Center
1997-2009
Rockefeller University
2004-2009
Population Council
2004-2009
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2009
University of Cambridge
1997
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBinding of hydroxamic acid inhibitors to crystalline thermolysin suggests a pentacoordinate zinc intermediate in catalysisM. A. Holmes and B. W. MatthewsCite this: Biochemistry 1981, 20, 24, 6912–6920Publication Date (Print):November 1, 1981Publication History Published online1 May 2002Published inissue 1 November 1981https://pubs.acs.org/doi/10.1021/bi00527a026https://doi.org/10.1021/bi00527a026research-articleACS PublicationsRequest reuse...
ABSTRACT: Physical and psychosocial stress challenge homeostasis, increasing glucocorticoid secretion (in rodents, corticosterone [CORT]) while decreasing testosterone (T) levels. The dynamics of stress‐induced changes in T, CORT, luteinizing hormone (LH) concentrations mice have not been investigated previously. In particular, it remains to be established whether there is a rapid effect CORT that directly mediated by receptors (GRs) the testis. Therefore, serum intratesticular LH levels...
Abstract PURPOSE This study was conducted to investigate the effect of Se supplementation on prostate cancer incidence in men at high risk for cancer. METHODS A Phase 3 randomized, double‐blind, placebo‐controlled clinical trial 699 (prostate specific antigen (PSA) >4 ng/ml and/or suspicious digital rectal examination PSA velocity >0.75 ng/ml/year), but with a negative biopsy. Participants were randomized receive daily oral placebo (N = 232), 200 µg selenium 234), or 400 233) as...
An oscillation data collection system for protein crystallography is described. The consists of a modified Enraf-Nonius precession camera with cylindrical cassette, and stepping motor driven by flexible microprocessor control system. X-ray source graphite-monochromatized radiation from an Elliott GX-21 rotating-anode generator run at 5.5 kW on focal spot measuring 0.5 × 5.0 mm. potential advantages using relatively large in conjunction graphite monochromator are discussed. Conditions optimum...
ABSTRACT: The free radical nitric oxide (NO), generated through the oxidation of l ‐arginine to ‐citrulline by NO synthases (NOSs), has been shown inhibit steroidogenic pathways. NOS isoforms are known be present in rat and human testes. Our study examined sensitivity Leydig cells determined whether activity resides or another cell type such as testicular macrophage. results showed a low level ‐[ 14 C]arginine conversion purified homogenates. Administration inhibitor L‐N G ‐nitro‐arginine...
There have been no extensive studies investigating the effect of tissue culture media on in vitro functional characteristics rat, porcine and human Islets Langerhans. We therefore aimed to compare ten commercially available basis their ability maintain islet viability. Following isolation, islets were cultured free-floating (RPMI 1640–11mM glucose (control), RPMI 1640–2.2mM glucose, Dulbecco's MEM, TCM 199, CMRL 1066, Iscove's Waymouth's Serum-Free medium, Ex-cell 300, Ham's F-12) viability...
ADVERTISEMENT RETURN TO ISSUEPREVArticleStructural analysis of the inhibition thermolysin by an active-site-directed irreversible inhibitorM. A. Holmes, D. E. Tronrud, and B. W. MatthewsCite this: Biochemistry 1983, 22, 1, 236–240Publication Date (Print):January 4, 1983Publication History Published online1 May 2002Published inissue 4 January 1983https://doi.org/10.1021/bi00270a034RIGHTS & PERMISSIONSArticle Views158Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are...
There have been no extensive studies investigating the effect of tissue culture media on in vitro functional characteristics rat, porcine and human Islets Langerhans. We therefore aimed to compare ten commercially available basis their ability maintain islet viability. Following isolation, islets were cultured free-floating (RPMI 1640-11mM glucose (control), RPMI 1640-2.2mM glucose, Dulbecco's MEM, TCM 199, CMRL 1066, Iscove's Waymouth's Serum-Free medium, Ex-cell 300, Ham's F-12) viability...
Radical prostatectomy is the most common treatment for localised prostate cancer in New Zealand. Active surveillance was introduced to prevent overtreatment and reduce costs while preserving option of radical prostatectomy. This study aims evaluate cost-effectiveness active compared watchful waiting Markov models were constructed estimate life-time low risk patients aged 45–70 years, using national datasets Zealand published studies including SPCG-4 study. from perspective Ministry Health...
Androgen deprivation therapy (ADT) is an effective palliation treatment in men with advanced prostate cancer (PC). However, ADT has well documented side effects that could alter the patient's health-related quality of life (HRQoL). The current study aims to test whether a genetic stratification provide better knowledge for optimising options minimize HRQoL effects. A cohort 206 PC survivors (75 treated and 131 without ADT) was recruited written consent collect patient characteristics,...
Purpose: To determine whether volume (10 or 20mL) the presence of 2% lidocaine (lignocaine) in gel used for urethral lubrication alters discomfort felt during flexible cystoscopy. Patients and Methods: A randomized double-blind trial was performed men attending were assigned to one four groups: 10 mL with without 20 lidocaine. Gel retained minutes prior Pain both instillation cystoscopy itself evaluated using a visual analog scale (0-10). Results: Interim analysis after 147 patients had been...
Epidemiological data suggest robust associations of high vegetable intake with decreased risks bladder cancer incidence and mortality, but translational prevention studies have yet to be conducted. We designed tested a novel intervention increase in patients noninvasive cancer. randomized 48 aged 50 80 years biopsy-proven (Ta, T1, or carcinoma situ) urothelial cell telephone- Skype-based dietary counseling control condition that provided print materials only. The behavioral goals promoted...
Reduction in bone mineral density (BMD) is a common side effect of androgen deprivation therapy (ADT). We aimed to examine the cross-sectional and longitudinal variation BMD associated markers patients with nonmetastatic prostate cancer (PCa) managed without ADT.Bone total body, lumbar spine, femoral neck, ultradistal forearm, one-third distal radius was measured 88 PCa metastases at baseline 6 months. Patients were categorized into 4 groups: (1) acute ADT (≤6 months), (2) chronic (>6 (3)...
We have determined the crystal structure of Fv fragment a humanized anti-hen eggwhite lysozyme Ab (HuLys). This molecule is composite known structures: complementarity-determining regions (CDRs) were from mouse anti-lysozyme D1.3, heavy chain framework human myeloma protein NEW, and light consensus sequences similar to Bence Jones REI. HuLys crystallized in space group P4(3)2(1)2, with two molecules crystallographic asymmetric unit. The was solved by molecular replacement, using parent...
Objective To ascertain the rates and patterns of prostate-specific antigen (PSA) screening in New Zealand men. Methods The study population included 35,958 men aged 40+ years, with no prior diagnosis prostate cancer, enrolled 31 general practices Midland Cancer Network Region 2010. Computerized practice records were searched for information, including reasons testing, elevated PSA test results 2007–2010 obtained from community laboratories. Screened identified calculated by age. Results Of...
To compare blood loss, irrigation requirements and hospital stay between standard transurethral resection of the prostate (TURP) incorporating vaporization, i.e. vaporization (TUVRP).Seventy patients were prospectively randomized in a blinded fashion TURP with loop (thin loop) or roller cutting electrode (thick loop). The outcome was assessed as change haemoglobin at 30 min 24 h after finished. Secondary measures requirements, length catheterization, stay, changes serum sodium,...
This study aims to examine the survival disparity between Māori men and New Zealand (NZ) Europeans diagnosed with prostate cancer. We identified aged 40+ years in Midland Cancer Network region registered cancer 2007–2010 Registry. Data were extracted from patient notes of all a sample NZ Europeans. The was estimated by Kaplan–Meier method Cox proportional-hazards regression models after adjusting for other factors. included 535 (135 400 Europeans). 5-year cancer-specific 98.6% localised...
The hormonal changes associated with immobilization stress (IMO) include a swift increase in corticosterone (CORT) concentration and decrease circulating testosterone (T) levels. There is evidence that the production of short-lived neuromodulator nitric oxide (NO) increased during various tissues, including brain. NO also suppresses biosynthesis T. Both inducible neuronal isoforms synthase (iNOS nNOS, respectively) have been implicated this suppression, but has not conclusive. We used adult...