A5066571690- PARP inhibition in cancer therapy
- DNA Repair Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Vectors
- COVID-19 Clinical Research Studies
- Acute Myeloid Leukemia Research
- Suicide and Self-Harm Studies
- COVID-19 and Mental Health
- Vector-borne infectious diseases
- COVID-19 epidemiological studies
- Mosquito-borne diseases and control
- Integrated Circuits and Semiconductor Failure Analysis
- SARS-CoV-2 detection and testing
- Vaccine Coverage and Hesitancy
- Rabies epidemiology and control
- Lung Cancer Treatments and Mutations
- Viral Infections and Outbreaks Research
- Long-Term Effects of COVID-19
- Air Quality and Health Impacts
- Psychosomatic Disorders and Their Treatments
- Medical Imaging Techniques and Applications
- Climate Change and Health Impacts
- Pesticide Exposure and Toxicity
- Toxin Mechanisms and Immunotoxins
- Cancer therapeutics and mechanisms
Institut Pierre Louis d‘Épidémiologie et de Santé Publique
2021-2024
Inserm
2017-2023
Sorbonne Université
2021-2023
Laboratoire de Génie des Procédés – Environnement – Agro-alimentaire
2020-2022
Biologie Epidémiologie et Analyse de Risque en santé animale
2020-2022
Oniris
2018-2021
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2021
UPMC Hillman Cancer Center
2015-2019
Bordeaux Population Health
2017-2018
Université de Bordeaux
2017
In preclinical studies, the PARP inhibitor veliparib enhanced antileukemic action of temozolomide through potentiation DNA damage. Accordingly, we conducted a phase 1 study with escalating doses in patients relapsed, refractory acute myeloid leukemia (AML) or AML arising from aggressive malignancies.
Abstract Data on the SARS-CoV-2 infection among primary health care workers (PHCWs) are scarce but essential to reflect policy regarding prevention and control measures. We assessed prevalence of PHCWs who have been infected by in comparison with modeling from general population metropolitan France, associated factors. A cross-sectional study was conducted practitioners (GPs), pediatricians, dental pharmacy between May August 2021. Participants volunteered provide a dried-blood spot for...
Abstract Domestic ruminants (cattle, goats and sheep) are considered to be the main reservoirs for human Coxiella burnetii infection. However, there is still a need assess specific contribution of cattle. Indeed, most seroprevalence studies in humans were carried out areas comprising both cattle small ruminants, latter being systematically implicated Q fever outbreaks. Therefore, we conducted cross-sectional study where C. infection was endemic, density ruminant farms respectively high very...
We aimed to investigate the immunoglobulin G response and neutralizing activity against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) among primary health care workers (PHCW) in France assess association between several factors, including coronavirus disease 2019 (COVID-19) vaccination scheme. A cross-sectional survey was conducted 10 May 2021 31 August 2021. Participants underwent capillary blood sampling completed a questionnaire. Sera were tested for presence of antibodies...
The protocol study will focus on the seroprevalence of IgG antibodies to SARS-CoV-2 achieved by vaccination and/or natural protection as well history, symptoms, and risk factors for in four primary health-care workers (PHCWs) their household contacts metropolitan France.
Q fever, a zoonotic disease caused by Coxiella burnetii, is endemic among cattle in Western France. However, studies assessing the risk of human infection such areas are lacking to date, while they may provide information about key specific preventive actions which could be advised populations living with or close cattle. Therefore, we conducted cross-sectional study two departments France during 2017/18 winter order explore possible factors for seropositivity distinct populations, i) an...
Asthma is the most common chronic disease in children. However little known about impact of airborne pesticide exposure on children respiratory health rural area. The objective our study was to determine if had an <b>Methods:</b> In a vineyard area, from selected schools were invited participate during two periods (winter with no pesticides air, and summer exposure). Health outcomes both asthma rhinitis symptoms. Exposure evaluated by i.e. ambient air at building cumulative index, ethylene...
This study aimed to estimate the seroprevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection within staff and student populations University Corsica (France) during second wave epidemic.A cross-sectional survey was conducted from 23 November 2020 31 January 2021. The participants underwent blood sampling using a fingerstick procedure completed an anonymized questionnaire. Sera were tested for presence anti-SARS-CoV-2 IgG (ELISA-S) and, if positive, with in-house...
Background Most studies published to date have investigated the impact of COVID-19 pandemic on suicidal acts using hospital data. Trends from primary care in a country such as France are crucial, individuals may not consult services after suicide attempts (SAs) but rather see their general practitioner (GP). Objectives We aimed evaluate whether incidence and characteristics SAs completed suicides (CSs) reported French GPs were different during than those before. Methods findings conducted...
<p>Table S1. Changes in Proportion (%) of γH2AX-Positive Cells Peripheral Blood upon Veliparib and Veliparib/Temozolomide Treatment Figure FANCD2 monoubiquitination following ex vivo melphalan treatment patient bone marrow cells S2.Pretreatment levels PARP1 MGMT S3.Pretreatment promoter methylation peripheral blood (PB) or (BM) AML S4. PARP inhibition cells</p>
<div>Abstract<p><b>Purpose:</b> In preclinical studies, the PARP inhibitor veliparib enhanced antileukemic action of temozolomide through potentiation DNA damage. Accordingly, we conducted a phase 1 study with escalating doses in patients relapsed, refractory acute myeloid leukemia (AML) or AML arising from aggressive malignancies.</p><p><b>Experimental Design:</b> Patients received [20–200 mg once day on and twice daily days 4–12 cycle (days...
<div>Abstract<p><b>Purpose:</b> In preclinical studies, the PARP inhibitor veliparib enhanced antileukemic action of temozolomide through potentiation DNA damage. Accordingly, we conducted a phase 1 study with escalating doses in patients relapsed, refractory acute myeloid leukemia (AML) or AML arising from aggressive malignancies.</p><p><b>Experimental Design:</b> Patients received [20–200 mg once day on and twice daily days 4–12 cycle (days...
<p>Table S1. Changes in Proportion (%) of γH2AX-Positive Cells Peripheral Blood upon Veliparib and Veliparib/Temozolomide Treatment Figure FANCD2 monoubiquitination following ex vivo melphalan treatment patient bone marrow cells S2.Pretreatment levels PARP1 MGMT S3.Pretreatment promoter methylation peripheral blood (PB) or (BM) AML S4. PARP inhibition cells</p>
Abstract Background Data on the SARS-CoV-2 infection among primary health care workers (PHCWs) are scarce but essential to reflect policy regarding prevention and control measures. Aim We assessed prevalence of PHCWs who have been infected by in comparison with modeling from general population metropolitan France, associated factors. Methods A cross-sectional study was conducted practitioners (GPs), pediatricians, dental pharmacy between May-August 2021. Participants volunteered provide a...