The novel Gallium-68 prostate-specific membrane antigen (PSMA)-bis [2-hydroxy-5-(carboxyethyl)benzyl] ethylenediamine-diacetic acid positron emission tomography (PET) tracer is increasingly used in the evaluation of prostate cancer, particularly detection recurrent disease. However, PSMA expressed nonprostatic tissues, as well other pathologic conditions. Here we illustrate such interpretive pitfalls with relevant images that one may encounter while reporting PET/CT. This study aims to show...

A 71-year-old man with a background of treated stage IIIB non–small cell lung cancer was referred for 68Ga prostate-specific membrane antigen (PSMA) PET/CT staging prostate cancer. In addition to the PSMA uptake in known malignancy, study also demonstrated increased an enlarging left lower lobe mass diffusely enlarged thyroid gland and bilateral supraclavicular lymph nodes. Fine-needle aspiration biopsy node metastatic adenocarcinoma from primary

Physiological cardiac hypertrophy is a compensatory remodeling of the heart in response to stimuli such as exercise training or pregnancy that reversible and well-tolerated. We previously described how activating transcription factor 6 (ATF6) proteins, ATF6α ATF6β, were required for pathological hemodynamic stress. Here, we examine functional roles both ATF6 proteins context exercise-induced physiological hypertrophy. After 20 days swim training, found differential roles: whole body...

Abstract Background Positron‐emission tomography (PET) imaging using [ 18 F]fluorodeoxyglucose (FDG) is useful for detection, staging, and monitoring a variety of malignancies, including lymphoma, in adults, but its utility sarcomas, especially soft tissue sarcomas (STS), children young adults not clear. Procedure To evaluate the potential FDG PET care STS we analyzed 46 scans 25 patients acquired over 12 years. Scans were interpreted by two physicians blinded to findings from other studies...

68Ga-PSMA PET/CT is increasingly used to evaluate recurrent prostatic malignancy due its high specificity. A 75-year-old man with a previous history of treated prostate cancer 3 years earlier presented rising prostate-specific antigen (PSA) level and underwent which demonstrated PSMA-avid focus in the neck pancreas. Triple-phase abdominal CT enhancement arterial phase lesser extent venous soft tissue mass Cytological histopathological examination confirmed low-grade pancreatic neuroendocrine tumor.

Flurodeoxyglucose PET (FDG PET) is very useful for staging and restaging adult lymphomas. Its effectiveness in childhood lymphomas less established. To evaluate the potential utility of FDG care pediatric patients with lymphomas, we examined clinical data imaging findings 26 patients, 8 – 19 years age (14 HD, 12 NHL) who underwent 55 studies. Results were compared CT/MRI gallium scans. provided incremental, clinically important information 21% HD cases 33% NHL cases. It was especially...

Objective This article delineates best practices in the application of experimental therapeutics framework for evaluating interventions within context randomized controlled trials (RCTs), offering a methodological primer and guiding this approach. We illustrate these using an ongoing clinical trial conducted National Institute Mental Health exploratory phased-innovation award development psychosocial therapeutic mental disorders (R61/R33), describing implementation novel "Facial Affect...

Objective: Prolonged experiences of discrimination can be a major source physical and health-related stress, particularly in older Black Americans. However, there is limited information on the relation between anxiety, within context other constructs that influence manifestation anxiety symptoms. For example, several studies have suggested ethnic identification may provide psychological social resources to deal with effects discrimination. This study aims further understand these...

Defects in myofibroblast function may cause wound healing defects a variety of tissue types. Here we describe simple skin-punch biopsy approach to screen mouse models for closure that does not require extensive surgical training or expensive equipment. Experimental results serve as an initial proof concept determine whether further investigation is necessary if observed other systems also result reduced skin healing.

Computed tomography ventilation imaging (CTVI) is a highly accessible functional lung modality that can unlock the potential for avoidance in cancer radiation therapy. Previous attempts to validate CTVI against clinical single-photon emission computed (V-SPECT) have been hindered by radioaerosol clumping artifacts. This work builds on those studies performing first comparison of with 99m Tc-carbon ('Technegas'), V-SPECT featuring smaller particles less clumping.Eleven radiotherapy patients...

Research results on the effects of aquaculture poverty alleviation have been mixed. We use Tobit, simulation models and cross sectional survey data 285 households, in Ben Tre Province, Vietnam, to evaluate involvement poverty, measured using per capita consumption less than $1.25 USD, $1.50, $2.00 day. The show for day that households' participation or productivity had no little effect living standard. For income levels above influenced standard living.

To determine the incidence of chest neoplasms detected by FDG PET in patients with previously treated squamous cell head and neck cancer (HNC), being evaluated for possible recurrent disease.This is a retrospective review 41 (M = 29, F 12: average age 58 years) HNC who underwent as part routine evaluation locoregional and/or distant recurrence. Thirty-four had advanced stage III or IV HNC. All studies were reviewed dedicated nuclear medicine physicians, including abnormal uptake chest. The...

A 68-year-old man with treated prostate cancer 3 years earlier and small cleaved B-cell follicular lymphoma diagnosed 1 year prior monitored clinically no active intervention (“watch wait” approach) was referred for 68Ga–prostate-specific membrane antigen (PSMA) PET/CT rising prostate-specific level. demonstrated diffuse PSMA uptake in the (SUVmax 3.6) multiple PSMA-avid nonenlarged lymph nodes. Moderate 4.7) also noted an enlarged right inguinal node 4.7), which on core biopsy confirmed lymphoma.

To evaluate the use of Gallium-68 prostate-specific membrane antigen positron emission tomography/computed tomography (68Ga-PSMA PET/CT), compared with conventional CT abdomen/pelvis (CTAP) and whole body single photon bone scan (BS), for detection local or distant metastasis following biochemical failure/recurrence in post-prostatectomy patients.We conducted a review our prospectively maintained, institutional database to identify 384 patients who underwent PSMA PET/CT, CTAP BS from...

Abstract This study originated in collaboration with Thomas Dishion because of concerns that a group format for aggressive children might dampen the effects cognitive-behavioral intervention. Three hundred sixty preadolescent were screened through teacher and parent ratings. Schools randomized to receive either an individual or child component same evidence-based program. The results indicate there is variability how group-based intervention can affect long 4-year follow-up after end...

Shrimp production and exports are important to rural economic development of Vietnam. The growth in has accelerated the past decade, but so too have been losses from natural disasters diseases. To protect famers disease losses, government established a subsidized pilot insurance program with expectation free market liberalization at end three-year trial. failed because inadequate pre-program information on farmers risk management strategies their willingness pay an premium. In this paper, we...

Prostate specific membrane antigen (PSMA) is expressed by hepatocellular carcinoma (HCC). PSMA PET/CT has potential as an imaging agent for the detection of HCC including early diagnosis and monitoring recurrence following surgical resection. This study aims to compare PET standard surveillance in HCC. Patients with suspected or treated were prospectively recruited from a tertiary hospital outpatient clinic. In addition routine recommended multidisciplinary team, was performed. Imaging...

Background and objective There are overwhelming health disparities in the Deep South. It is important to include voice of communities affected by these when developing interventions. The goal current study was develop an academic community engaged partnership strengthen ability address priority concerns rural African American with a focus on literacy advocacy. Methods A community-based participatory research approach used administer 15-item survey five led mayors Alabama ( N = 752). assessed...

Indium-111 octreotide scintigraphy is a useful investigation in the diagnosis and staging neuroendocrine or nonendocrine malignancies such as carcinoid, granulomas, small cell lung cancer, medullary thyroid carcinoma, others. Tumors with large numbers of somatostatin receptors can be accurately imaged this guiding treatment. Although uncommon, false-positives studies have been reported often cause unexplained but assumed to high number other pathology. We present case increased uptake...

Abstract Background To evaluate the efficacy of fluorine‐18‐fluorodeoxyglucose emission tomography (FDG‐PET) and CT versus endoscopy with biopsy under general anesthesia for estimating tumor volume reduction among patients treated induction chemotherapy advanced squamous cell carcinoma (SCC) oropharynx. Methods Twelve oropharyngeal SCC nested in a phase II, chemoradiation, organ preservation trial (University Michigan Cancer Center 9921) underwent estimation as assessed by FDG‐PET, CT,...

Ga-prostate-specific membrane antigen (PSMA) PET/CT is increasingly used to evaluate recurrent prostatic malignancy due its high specificity. A 56-year-old man with previous history of treated prostate cancer 4 years earlier presented rising prostate-specific level and underwent Ga-PSMA PET/CT, which demonstrated an enlarging pulmonary nodule without PSMA avidity. The nodule, however, showed moderate uptake on a corresponding FDG study, suspicious primary lung malignancy. Cytological...