A5102021906- Muscle metabolism and nutrition
- Ion channel regulation and function
- Cardiovascular and exercise physiology
- Pharmacological Effects and Assays
- Ion Transport and Channel Regulation
- Vitamin D Research Studies
- Emergency and Acute Care Studies
- Adipose Tissue and Metabolism
- Folate and B Vitamins Research
- Exercise and Physiological Responses
- Metabolism and Genetic Disorders
- Sepsis Diagnosis and Treatment
- Sports Performance and Training
- Diet and metabolism studies
- Nutrition and Health in Aging
- Gastrointestinal motility and disorders
- Alcoholism and Thiamine Deficiency
- Bone health and osteoporosis research
- Pancreatic function and diabetes
- Cardiac Arrest and Resuscitation
- Inflammatory Bowel Disease
- Neurological and metabolic disorders
- Biochemical Acid Research Studies
- Education, Healthcare and Sociology Research
- Metabolism, Diabetes, and Cancer
Samsø Energy Academy
2024
University College Copenhagen
2018-2022
University of Copenhagen
1999-2019
Zealand University Hospital
2015-2019
Metropolitan University College
2017-2018
Amager Hospital
2018
Aarhus University Hospital
2017
University of Oslo
2017
Zealand University Hospital Køge
2017
Copenhagen University Hospital
2015
A rise in extracellular potassium concentration human skeletal muscle may play an important role development of fatigue during intense exercise. The aim the present study was to examine effect intermittent training on interstitial kinetics and its relationship density Na(+),K(+)-ATPase subunits K(ATP) channels, as well exercise performance, muscle. Six male subjects performed one-legged knee-extensor for 7 weeks. On separate days trained leg (TL) control (CL) a 30 min period W incremental...
We examine the influence of cytosolic and membrane-bound contents carbonic anhydrase (CA; CAII, CAIII, CAIV, CAXIV) muscle content proteins involved in lactate proton transport [monocarboxylate transporter (MCT) 1, MCT4, Na(+)/H(+) exchanger 1 (NHE1)] on work capacity during supramaximal exercise. Eight healthy, sedentary subjects performed exercises at 120% rate corresponding to maximal oxygen uptake (W(max)) until exhaustion placebo (Con) metabolic alkalosis (Alk) conditions. The total...
Regional cerebral blood flow (rCBF) was measured with high resolution brain dedicated single photon emission computer tomography (SPECT) and [99mTc]-d,l-hexamethyl-propylene-amine-oxime (HMPAO) in 25 patients probable Alzheimer9s disease control subjects, selected according to rigorous inclusion exclusion criteria. The aim analyse the topography of rCBF deficits individual patients. In group as a whole, global CBF reduced, but factorial analysis variance did not show disproportionate...
Introduction - Although the cause of amyotrophic lateral sclerosis (ALS) is unknown, excitotoxicity mediated by glutamate has been implicated. Dextromethorphan a NMDA-glutamate receptor antagonist with neuroprotective properties. Material and methods The effect treatment dextromethorphan (150 mg daily) in ALS patients was evaluated randomized, double-blind, placebo-controlled study. Forty-five were included analysis. Results At end period, 12 months after randomization, 15 (65%) placebo...
Lactic acid accumulation is generally believed to be involved in muscle fatigue. However, one study reported that rat soleus (in vitro), with force depressed by high external K(+) concentrations a subsequent incubation lactic restores and thereby protects against 20 mm reduces the pH gradient across sarcolemma, whereas increased during activity. Furthermore, unlike active Na(+)-K(+) pump not activated. We therefore hypothesized does protect fatigue muscle. Three solutions were used: mM...
The cobalamin status was evaluated in Alzheimer dementia (n = 26), other dementias 24), various gerontopsychiatric disorders 25), and neuro-psychiatrically healthy controls 20). Supplementing serum we measured methylmalonic acid (MMA), a metabolite accumulating early deficiency. Subnormal and/or clearly elevated MMA concentrations were found 11 cases: 7 patients (27%), 2 with (8%), one psychiatric patient (4%), control (5%). None presented the typical neurologic features of deficiency...
Objective To compare the Danish Emergency Process Triage (DEPT) with a quick clinical assessment (Eyeball triage) as predictors of short-term mortality in patients emergency department (ED). Methods The investigation was designed prospective cohort study conducted at North Zealand University Hospital. All patient visits to ED from September 2013 December except minor injuries were included. DEPT performed by nurses. Eyeball triage non-systematic based on appearance phlebotomists. Both...
The present study investigated the localization of ATP-sensitive K + (K ATP ) channels in human skeletal muscle and functional importance these for distribution at rest during activity. Membrane fractionation based on giant vesicle technique or sucrose-gradient combination with Western blotting demonstrated that are mainly located sarcolemma. This was confirmed by immunohistochemical measurements. With microdialysis technique, it local application channel inhibitor glibenclamide reduced ( P...
Muscle activity is associated with potassium displacements, which may cause fatigue. It was reported previously that the density of large-conductance Ca 2+ -dependent K + (BK ) channel higher in T tubule membrane than sarcolemmal and opposite case for ATP-sensitive (K ATP channel. In present experiments, we investigated subcellular localizations strong inward rectifier 2.1 (Kir2.1) Na -K -2Cl − (NKCC)1 cotransporter Western blot analysis different muscle fractions. Furthermore, function...
The bone mineral content was measured in 10 epileptic patients on long-term treatment with phenytoin before and during vitamin D. None of the showed biochemical signs osteomalacia. Initially subnormal values for were found, which increased significantly treatment. results suggest occurrence latent osteomalacia a fairly high proportion anticonvulsants.
Peptide receptor radionuclide therapy (PRRT) is a relatively new mode of internally targeted radiotherapy currently in clinical trials. In PRRT, ionizing radioisotopes conjugated to somatostatin analogues are neuroendocrine tumors (NETs) via receptors. Despite promising results, very little known about the mechanism tumor control. By using NCI-H727 cells an vivo murine xenograft model human NETs, we showed that (177)Lu-DOTATATE PRRT led increased infiltration CD86+ antigen presenting into...
Patient crowding in emergency departments (ED) is a common challenge and associated with worsened outcome for the patients. Previous studies on biomarkers ED setting has focused identification of high risk patients, ability to use identify low-risk patients only been sparsely examined. The broader aims TRIAGE study are develop methods appropriate early discharge by combining information from wide range new inflammatory vital signs, present baseline article describe formation database...
Abstract Background Deficient and insufficient vitamin D status (defined as serum 25(OH)D < 30 nmol/L > 50 nmol/L) is prevalent worldwide associated with decreased muscle strength poor bone health. We aimed to investigate the effect of fortification on markers among younger adult women at risk deficiency. Methods A 12-week randomised double-blinded placebo-controlled winter intervention trial, providing μg 3 /day through fortified yoghurt, cheese, eggs crisp-bread or similar placebo...
Prioritization of acutely ill patients in the Emergency Department remains a challenge. We aimed to evaluate whether routine blood tests can predict mortality unselected an emergency department and compare risk prediction with formalized triage algorithm. A prospective observational cohort study 12,661 consecutive admissions Nordsjælland University Hospital during two separate periods 2010 (primary cohort, n = 6279) 2013 (validation 6383). Patients were triaged five categories by All full...
Impaired muscle function has been coupled to vitamin D insufficiency in young women and elderly men women. Those living at Northern latitudes are risk for due low sun exposure which may be more pronounced among elite swimmers because of their indoor training schedules. We aimed examine status evaluate the association between strength. Twenty-nine swimmers, 12 female 17 male (16-24 years) residing latitude 55-56°N were studied March April. Blood samples analyzed serum 25-hydroxyvitamin...
Abstract Background Nursing home residents are in high risk of vitamin D deficiency, which negatively affects bone health. Vitamin and calcium supplements haves shown to increase density reduce fracture risk. Therefore, The Danish Health Authority recommends all nursing a daily supplement 20 μg 800–1000 mg calcium. However, adherence the recommendation knowledge it is unknown. aims this study were investigate adherence, knowledge, potential barriers Denmark. Methods A cross-sectional...
Abstract The clinical value of measuring concentrations methylmalonic acid in serum (S-MMA) as an aid the diagnosis cobalamin deficiency has recently aroused interest. In 58 healthy subjects, ages 40-68 years, we found a 0.95 reference interval 0.05-0.37 mumol/L (mean 0.21, SD 0.094). 33 who were studied further, day-to-day variation (SD) was 0.031 mumol/L. Intake food had no effect. Weekly and three-monthly intra-individual variations both 0.038 all seven subjects with S-MMA greater than...