A5040667984- interferon and immune responses
- NF-κB Signaling Pathways
- X-ray Diffraction in Crystallography
- Hormonal Regulation and Hypertension
- Crystallization and Solubility Studies
- Endometriosis Research and Treatment
- Sirtuins and Resveratrol in Medicine
- Bioactive natural compounds
- CRISPR and Genetic Engineering
- Genomics and Chromatin Dynamics
- Synthesis of Organic Compounds
- PARP inhibition in cancer therapy
- Synthesis and biological activity
- Phytochemistry and biological activity of medicinal plants
- Ferrocene Chemistry and Applications
- Ginseng Biological Effects and Applications
- Gout, Hyperuricemia, Uric Acid
- Natural product bioactivities and synthesis
- Adenosine and Purinergic Signaling
- Immune Response and Inflammation
- Pharmacological Effects of Natural Compounds
- Neurogenesis and neuroplasticity mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Biochemical Acid Research Studies
- Phosphodiesterase function and regulation
Hefei University
2017-2025
Anhui Medical University
2017-2023
Pterostilbene (PST) is a naturally derived stilbene compound in grapes, blueberries, and other fruits. It also natural dietary with wide range of biological activities such as antioxidant, anti-inflammatory, antitumor, so on. Structural modifications based on the chemical scaffold pterostilbene skeleton are great importance for drug discovery. In this study, skeletons were used to design novel anti-inflammatory compounds high activity low toxicity. A total 30 new found synthesised, their...
It has been reported that 17β-HSD10 plays a key role in Alzheimer's disease. Here, total of 44 2-phenyl-1H-benzo[d]imidazole derivatives were designed and synthesized as novel inhibitors based on rational design SAR studies. Among them, compound 33 (N-(4-(1,4,6-trimethyl-1H-benzo[d] imidazol-2-yl)phenyl)cyclohexanecarboxamide) showed high inhibitory efficacy (17β-HSD10 IC50 = 1.65 ± 0.55 μM) low toxicity (HepaRG >100 μM). The Morris water maze experiment revealed could alleviate cognitive...
Based on the SAR analysis of glycyrrhizin, 18α-glycyrrhetinic acid monoglucuronide (18α-GAMG) with strong inhibition against LPS-induced NO and IL-6 production in RAW264.7 cells was discovered. Western blotting immunofluorescence results showed that 18α-GAMG reduced expression iNOS, COX-2, MAPKs, as well activation NF-κB LPS-stimulated cells. Further vivo could significantly improve pathological changes CCl4-induced hepatic fibrosis.
A series of novel 4-ferrocenylchroman-2-one derivatives were designed and synthesised to discover potent anti-inflammatory agents for treatment arthritis. All the target compounds had been screened their activity by evaluating inhibition effect LPS-induced NO production in RAW 264.7 macrophages. Among them, 4-ferrocenyl-3,4-dihydro-2H-benzo[g]chromen-2-one (3h) was found be most compound inhibiting productions with low toxicity. This also exhibited significant IL-6 TNF-α Preliminary...
The aberrant activation of NLRP3 inflammasomes is intricately linked to various inflammatory diseases. In this study, we present the discovery and optimization a series inflammasome inhibitors based on pterostilbene skeleton. All compounds underwent screening evaluate their inhibitory effects LPS/Nigericin-induced IL-1β secretion anti-cellular pyroptosis. Most exhibit good biological activity cellular safety, with compound D20 showing most prominent activity. Preliminary mechanism studies...
Abstract A series of novel pathalide‐1,2,4‐oxadiazole analogs were synthesized for discovering anti‐inflammatory agents. After the assessment their cytotoxicity in vitro , all compounds had been screened activity by evaluating inhibitory effect on LPS‐induced NO production RAW 264.7 macrophages. SARs concluded, and finally compound E13 was found to be most potent compound. This could also significantly decrease iNOS COX‐2. Preliminary mechanism studies indicated that inhibit TLR4/NF‐κB...